Effect of Per-cutaneous Nephrosotomy Drainage on Radioisotope Imaging of Hydronephrotic Kidneys

NCT03695991 | Unknown

• 1 other identifier: PCNHK
• Study Type: observational
• Target: 62
• Locations: 0 countries
• Sites: N/A

Brief Summary

Hydronephrosis describes a condition of urine-filled dilation of the collecting system. Normally, urine flows through the urinary tract with minimal or low pressure. If the build-up of excess fluid in the urinary collecting system continues, there will be an increase in pressure and atrophy of renal cortex. If hydronephrosis is left untreated for a long time, renal damage with permanent loss of function occurs

Conditions

Hydronephrosis

Outcome Measures

Primary Outcomes (1)

• The rate of increase in glomerular filtration rate after intervention

  the radioisotope measurement of glomerular filtration rate will be done before and after insertion of percutaneous nephrostomy tube

  3 weeks

Study Arms (1)

Study group

Patients will be recruited from out-patient clinics and in-patient sectors of Assiut Urology and Nephrology hospital

Procedure: percutaneous nephrostomy

Interventions

percutaneous nephrostomy PROCEDURE

The percutaneous nephrostomy will be done under sonographic or fluoroscopic guidance. Establishment of intravenous access and antibiotics will be performed half an hour prior to procedure particularly in patients presenting with urinary tract infection. The procedure will be done under local anesthesia but general anesthesia may be used for uncooperative patients. percutaneous nephrostomy will be performed in the prone position, however, in case of relative contraindication to prone position

Study group

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients will be recruited from out-patient clinics and in-patient sectors of Assiut Urology and Nephrology hospital

You may qualify if:

• \) Patients for whom a percutaneous nephrostomy is indicated provided that the hydronephrosis is advanced ( parenchymal thickness not more than 5 mm ) 2) Patients for whom a nephrectomy is planned for a seemingly poorly functioning kidney along with either

You may not qualify if:

• Target kidney is the only functioning or better functioning kidney or otherwise substantially contributing to the total renal function, so nephrectomy is not likely.
• Emergency cases where the general condition of the patient cannot withstand the logistics of undergoing a radioisotope study eg
• Malignancy in the target kidney
• Patients unlikely to undergo a nephrectomy

Sponsors & Collaborators

• Assiut University: lead

MeSH Terms

Conditions

Hydronephrosis

Interventions

Nephrostomy, Percutaneous

Condition Hierarchy (Ancestors)

Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Intervention Hierarchy (Ancestors)

Diagnostic Techniques, Urological; Diagnostic Techniques and Procedures; Diagnosis; Ostomy; Surgical Procedures, Operative; Nephrotomy; Urologic Surgical Procedures; Urogenital Surgical Procedures; Urinary Diversion

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: October 3, 2018
• First Posted: October 4, 2018
• Study Start: May 1, 2019
• Primary Completion: October 1, 2020
• Study Completion: December 1, 2020
• Last Updated: April 16, 2019

Record last verified: 2019-04