NCT03916263

Brief Summary

Compare weight loss and metabolic parameters in patients using a low starch dietary education program vs. traditional treatment (i.e., prescribing metformin, low calorie diet and exercise) for health improvement in women with PCOS.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
71

participants targeted

Target at P75+ for early_phase_1

Timeline
Completed

Started Aug 2018

Longer than P75 for early_phase_1

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 29, 2018

Completed
5 months until next milestone

First Submitted

Initial submission to the registry

January 21, 2019

Completed
3 months until next milestone

First Posted

Study publicly available on registry

April 16, 2019

Completed
3.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 10, 2022

Completed
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2022

Completed
Last Updated

August 7, 2023

Status Verified

August 1, 2023

Enrollment Period

4.1 years

First QC Date

January 21, 2019

Last Update Submit

August 4, 2023

Conditions

Keywords

PCOSDietVideo Instruction

Outcome Measures

Primary Outcomes (2)

  • Weight

    Weight

    8 weeks

  • BMI

    BMI

    8 weeks

Secondary Outcomes (6)

  • waist to hip ratio

    8 weeks

  • fasting glucose

    8 weeks

  • fasting insulin

    8 weeks

  • cholesterol

    8 weeks

  • testosterone

    8 weeks

  • +1 more secondary outcomes

Study Arms (3)

Traditional Treatment

EXPERIMENTAL

Participant receives recommendations for caloric intake, exercise and prescription for metformin if indicated

Drug: Metformin

One-On-One Low Starch Dietary Instruction

OTHER

Participant receives One-On-One Low Starch Dietary Instruction from Study Collaborator

Other: One-On-One Dietary Instruction

Low Starch Dietary Instruction by Video

OTHER

Participant receives Low Starch Dietary Instruction by Video Link

Other: Video Dietary Instruction

Interventions

Traditional care including diet, exercise and metformin

Also known as: Traditional care
Traditional Treatment

Participant receives one-on-one dietary counseling from study personnel

One-On-One Low Starch Dietary Instruction

Participant receives video dietary instruction

Low Starch Dietary Instruction by Video

Eligibility Criteria

Age18 Years - 45 Years
Sexfemale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Women ages 18-45
  • BMI of \>25 but \< 45
  • PCOS
  • Access to a computer/phone/electronic device with internet connection.

You may not qualify if:

  • Pregnancy
  • Abnormal thyroid stimulating hormone (TSH)
  • Hyperprolactinemia
  • adrenal hyperplasia
  • Cushing's disease Ovarian and adrenal tumors. Previous diagnosis of diabetes. History of eating disorder History of surgical weight loss procedure Persons with an inability to give informed consent Persons unable/unwilling to exercise or to prepare their own food

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Texas Tech Health Science Center

Lubbock, Texas, 79430, United States

Location

MeSH Terms

Conditions

Nutrition Disorders

Interventions

Metformin

Condition Hierarchy (Ancestors)

Nutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

BiguanidesGuanidinesAmidinesOrganic Chemicals

Study Officials

  • Jennifer L Phy, DO

    Texas Tech University Health Sciences Center

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
early phase 1
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: Prospective Randomized
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 21, 2019

First Posted

April 16, 2019

Study Start

August 29, 2018

Primary Completion

October 10, 2022

Study Completion

December 31, 2022

Last Updated

August 7, 2023

Record last verified: 2023-08

Data Sharing

IPD Sharing
Will share

Will post to Clinical Trials

Shared Documents
STUDY PROTOCOL, SAP, ICF, CSR, ANALYTIC CODE
Time Frame
2 years
Access Criteria
2 years

Locations