NCT03915964

Brief Summary

This post-marketing study is designed to compare the safety of baricitinib versus tumor necrosis factor (TNF) inhibitors with respect to venous thromboembolic events (VTEs) when given to participants with rheumatoid arthritis.

Trial Health

98
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Strong global presence with extensive site network
Enrollment
2,663

participants targeted

Target at P75+ for phase_4 rheumatoid-arthritis

Timeline
Completed

Started Apr 2019

Longer than P75 for phase_4 rheumatoid-arthritis

Geographic Reach
23 countries

258 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

April 12, 2019

Completed
4 days until next milestone

First Posted

Study publicly available on registry

April 16, 2019

Completed
9 days until next milestone

Study Start

First participant enrolled

April 25, 2019

Completed
6.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 28, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 28, 2025

Completed
Last Updated

July 22, 2025

Status Verified

July 1, 2025

Enrollment Period

6.1 years

First QC Date

April 12, 2019

Last Update Submit

July 21, 2025

Conditions

Outcome Measures

Primary Outcomes (1)

  • Time from First Dose of Study Treatment to First Event of Venous Thromboembolism (VTE)

    Time from First Dose of Study Treatment to First Event of VTE

    Baseline through Study Completion (Approximately 5.5 Years)

Secondary Outcomes (5)

  • Time from First Dose of Study Treatment to First Arterial Thromboembolic Event (ATE)

    Baseline through Study Completion (Approximately 5.5 Years)

  • Time from First Dose of Study Treatment to First Major Adverse Cerebro-Cardiovascular Event (MACE)

    Baseline through Study Completion (Approximately 5.5 Years)

  • Time from First Dose of Study Treatment to First Malignancy (excluding nonmelanoma skin cancer [NMSC])

    Baseline through Study Completion (Approximately 5.5 Years)

  • Time from First Dose of Study Treatment to First Opportunistic Infection

    Baseline through Study Completion (Approximately 5.5 Years)

  • Time from First Dose of Study Treatment to First Serious Infection

    Baseline through Study Completion (Approximately 5.5 Years)

Study Arms (3)

Baricitinib Low Dose

EXPERIMENTAL

Baricitinib administered orally.

Drug: Baricitinib

Baricitinib High Dose

EXPERIMENTAL

Baricitinib administered orally.

Drug: Baricitinib

TNF Inhibitor

ACTIVE COMPARATOR

Adalimumab or etanercept administered subcutaneously (SC) per standard of care.

Drug: TNF Inhibitor

Interventions

Administered orally.

Also known as: LY3009104
Baricitinib High DoseBaricitinib Low Dose

Administered SC

Also known as: Etanercept, Adalimumab
TNF Inhibitor

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Participants must have at least one of the following characteristics:
  • Documented evidence of a VTE prior to this study
  • At least 60 years of age
  • A body mass index (BMI) greater than or equal to 30 kilograms per meter squared (kg/m²), or
  • Age 50 to less than 60 years and BMI 25 to less than 30 kg/m².
  • Participants must have an inadequate response or intolerance to at least 1 disease-modifying antirheumatic drugs (DMARD) (synthetic or biologic).

You may not qualify if:

  • Participant should have no reason to not take a TNF inhibitor.
  • Participants must not be pregnant or breastfeeding.
  • Participants must not have had more than one VTE.
  • Participants must not have cancer.
  • Participants must not have active herpes zoster, serious infection, active tuberculosis, or any other serious illness.
  • Participants must not have had a live vaccine within four weeks of study start.
  • Participants must not have participated in any other clinical trial within four weeks of study start.
  • Participants must not have a history of IV drug use, other illicit drug abuse, or chronic alcohol abuse in the past year.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (261)

Arizona Arthritis & Rheumatology Research, PLLC

Flagstaff, Arizona, 86001, United States

Location

Arthrocare, Arthritiscare & Research Pc

Gilbert, Arizona, 85234, United States

Location

Arizona Arthritis & Rheumatology Research, PLLC

Glendale, Arizona, 85306, United States

Location

Arizona Arthritis & Rheumatology Research, PLLC

Mesa, Arizona, 85210, United States

Location

Hope Research Institute

Peoria, Arizona, 85381, United States

Location

Hope Research Institute

Phoenix, Arizona, 85018, United States

Location

Arizona Arthritis & Rheumatology Research, PLLC

Tucson, Arizona, 85704, United States

Location

Medvin Clinical Research - Covina

Covina, California, 91722, United States

Location

St Joseph Heritage Healthcare

Fullerton, California, 92835, United States

Location

Christine Thai, MD

Huntington Beach, California, 92648, United States

Location

Private Practice - Dr. Christine J. Leehealey

Irvine, California, 92604, United States

Location

Desert Medical Advances

Rancho Mirage, California, 92270, United States

Location

Rheumatology Center of San Diego

San Diego, California, 92128, United States

Location

East Bay Rheumatology Medical Group, Inc

San Leandro, California, 94578, United States

Location

Dan La, MD Inc

Tujunga, California, 91042, United States

Location

Robin K. Dore MD, Inc

Tustin, California, 92780, United States

Location

Inland Rheumatology & Osteoporosis Medical Group

Upland, California, 91786, United States

Location

Medvin Clinical Research - Weidmann

Van Nuys, California, 91405, United States

Location

Medvin Clinical Research - Whittier

Whittier, California, 90602, United States

Location

Stamford Therapeutics Consortium

Stamford, Connecticut, 06905, United States

Location

Rheumatology Associates of South Florida

Boca Raton, Florida, 33486, United States

Location

Suncoast Research Group

Miami, Florida, 33135, United States

Location

New Horizon Research Center

Miami, Florida, 33165, United States

Location

Suncoast Clinical Research, Inc.

New Port Richey, Florida, 34652, United States

Location

IRIS Research and Development, LLC

Plantation, Florida, 33324, United States

Location

Qps-Mra, Llc

South Miami, Florida, 33143, United States

Location

ForCare Clinical Research

Tampa, Florida, 33613, United States

Location

Arthritis & Rheumatology of Georgia

Atlanta, Georgia, 30342, United States

Location

Arthritis Center of North Georgia

Gainesville, Georgia, 30501, United States

Location

St. Luke's Intermountain Research Center

Boise, Idaho, 83702, United States

Location

Great Lakes Clinical Trials

Chicago, Illinois, 60640, United States

Location

Qualmedica Research, LLC

Evansville, Indiana, 47715, United States

Location

Alliance for Multispecialty Research, LLC

Wichita, Kansas, 67205, United States

Location

Center for Arthritis and Osteoporosis

Elizabethtown, Kentucky, 42701, United States

Location

Accurate Clinical Research

Lake Charles, Louisiana, 70605, United States

Location

The Center for Rheumatology and Bone Research

Wheaton, Maryland, 20902, United States

Location

NECCR PrimaCare Research

Fall River, Massachusetts, 02721, United States

Location

University of Michigan

Brighton, Michigan, 48116, United States

Location

West Michigan Rheumatology

Grand Rapids, Michigan, 49546, United States

Location

Advanced Rheumatology, PC

Okemos, Michigan, 48864, United States

Location

StudyMetrix Research

City of Saint Peters, Missouri, 63303, United States

Location

Clinvest Research LLC

Springfield, Missouri, 65807, United States

Location

Glacier View Research Institute

Kalispell, Montana, 59901, United States

Location

Physician Research Collaboration, LLC

Lincoln, Nebraska, 68516, United States

Location

Westroads Clinical Research, Inc.

Omaha, Nebraska, 68114, United States

Location

Allied Clinical Research

Reno, Nevada, 89519, United States

Location

Dartmouth-Hitchcock Medical Center

Lebanon, New Hampshire, 03756, United States

Location

Albuquerque Center for Rheumatology

Albuquerque, New Mexico, 87102, United States

Location

Albuquerque Clinical Trials, Inc.

Albuquerque, New Mexico, 87102, United States

Location

Santa Fe Rheumatology

Santa Fe, New Mexico, 87505, United States

Location

Accellacare - Charlotte

Charlotte, North Carolina, 28211, United States

Location

M3-Emerging Medical Research, LLC

Durham, North Carolina, 27704, United States

Location

Piedmont Rheumatology, P.A.

Hickory, North Carolina, 28602, United States

Location

Cape Fear Arthritis Care

Leland, North Carolina, 28451, United States

Location

PMG Research of Salisbury

Salisbury, North Carolina, 28144, United States

Location

PMG Research of Wilmington, LLC

Wilmington, North Carolina, 28401, United States

Location

Cincinnati Rheumatic Disease Study Group

Cincinnati, Ohio, 45242, United States

Location

Marietta Memorial Hospital

Marietta, Ohio, 45750, United States

Location

Paramount Medical Research & Consulting, LLC

Middleburg Heights, Ohio, 44130, United States

Location

Health Research of Oklahoma

Oklahoma City, Oklahoma, 73103, United States

Location

Oklahoma Medical Research Foundation

Oklahoma City, Oklahoma, 73104, United States

Location

East Penn Rheumatology Associates

Bethlehem, Pennsylvania, 18015, United States

Location

Altoona Center For Clinical Research

Duncansville, Pennsylvania, 16635, United States

Location

Clinical Research Center of Reading,LLC

Wyomissing, Pennsylvania, 19610, United States

Location

Pennsylvania Regional Center for Arthritis and Osteoporosis Research

Wyomissing, Pennsylvania, 19610, United States

Location

Regional Health Clinical Research

Rapid City, South Dakota, 57701, United States

Location

Accurate Clinical Management

Baytown, Texas, 77521, United States

Location

Arthritis & Osteoporosis Clinic of Brazos Valley

College Station, Texas, 77845, United States

Location

Biopharma Informatic, LLC

Houston, Texas, 77043, United States

Location

Accurate Clinical Management - Houston

Houston, Texas, 77084, United States

Location

Accurate Clinical Research

Houston, Texas, 77089, United States

Location

Research Physicians Network, LLC

Houston, Texas, 77089, United States

Location

Accurate Clinical Research

League City, Texas, 77573, United States

Location

Accurate Clinical Research, Inc.

San Antonio, Texas, 78229, United States

Location

Clinical Trials of Texas, Inc.

San Antonio, Texas, 78229, United States

Location

Accurate Clinical Management

Sugar Land, Texas, 77479, United States

Location

Dynamed Clinical Research, LP d/b/a DM Clinical Research

Tomball, Texas, 77375, United States

Location

DM Clinical Research/Rheumatology Clinic of Houston

Tomball, Texas, 77377, United States

Location

Arthritis Northwest, PLLC

Spokane, Washington, 99204, United States

Location

The Vancouver Clinic

Vancouver, Washington, 98664, United States

Location

CAMC Health Education and Research Institute Inc

Charleston, West Virginia, 25304, United States

Location

Optimus Clinical Research

Botany, New South Wales, 2019, Australia

Location

Genesis Research Services

Newcastle, New South Wales, 2292, Australia

Location

Rheumatology Research Unit

Maroochydore, Queensland, 4558, Australia

Location

Southern Clinical Research

Hobart, Tasmania, 7000, Australia

Location

Emeritus Research

Camberwell, Victoria, 3124, Australia

Location

Medizinische Universität Wien

Vienna, Vienna, 1090, Austria

Location

Wilhelminenspital

Vienna, Vienna, 1160, Austria

Location

Rheuma-Zentrum Oberlaa GmbH

Vienna, 1100, Austria

Location

Université Libre de Bruxelles - Hôpital Erasme

Brussels, Bruxelles-Capitale, Région de, 1070, Belgium

Location

ZNA Jan Palfijn

Merksem, Flanders, 2170, Belgium

Location

Reuma Clinic, Locatie Jaarbeurslaan

Genk, Limburg, 3600, Belgium

Location

Revmacentrum MUDr. Mostera, s.r.o.

Brno, Brno-město, 61500, Czechia

Location

Revmatologie.s.r.o.

Brno, Brno-město, 63800, Czechia

Location

Artroscan, s.r.o.

Ostrava, Moravskoslezský kraj, 722 00, Czechia

Location

INREA s.r.o.

Ostrava, Ostrava Město, 70300, Czechia

Location

ARTHROHELP s.r.o.

Pardubice, Pardubický kraj, 53002, Czechia

Location

Clintrial s.r.o.

Prague, Praha 10, 100 00, Czechia

Location

Revmatologie MUDr. Štejfová

Prague, Praha 4, 140 00, Czechia

Location

Revmatologicky ustav

Prague, Praha, Hlavní Mešto, 12850, Czechia

Location

REVMACLINIC s.r.o.

Brno, South Moravian, 61141, Czechia

Location

Medical Plus

Uherské Hradiště, Zlín, 686 01, Czechia

Location

PV Medical Services s.r.o.

Zlín, Zlín, 760 01, Czechia

Location

Revmatologicka ambulance

Prague, 14000, Czechia

Location

Affidea Praha, s.r.o.

Prague, 14800, Czechia

Location

Regionshospitalet Silkeborg

Silkeborg, Central Jutland, 8600, Denmark

Location

Reumatologisk Ambulatorie, Svendborg Hospital Odense Universitet Hospital

Svendborg, Region Syddanmark, 5700, Denmark

Location

CHU de Nice

Nice, Alpes-Maritimes, 06000, France

Location

CHU Strasbourg-Hautepierre

Strasbourg, Alsace, 67098, France

Location

Bordeaux University Hospital - Pellegrin

Bordeaux, Aquitaine, 33076, France

Location

Hôpital Edouard Herriot

Lyon, Auvergne-Rhône-Alpes, 69003, France

Location

Centre Hospitalier Regional D'Orleans

Orléans, Centre-Val de Loire, 45067, France

Location

Hôpital Pierre-Paul Riquet

Toulouse, Haute-Garonne, 31059, France

Location

Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu

Nantes, Loire-Atlantique, 44093, France

Location

Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois

Vandœuvre-lès-Nancy, Meurthe-et-Moselle, 54511, France

Location

CHD Vendee

La Roche-sur-Yon, Vendée, 85000, France

Location

Infirmerie Protestante de Lyon

Caluire-et-Cuire, 69300, France

Location

Centre Hospitalier Régional Universitaire de Lille - Hôpital Roger Salengro

Lille, 59037, France

Location

Pitie Salpetriere University Hospital

Paris, 75013, France

Location

CIRI- Center of Innovative Diagnostics and Therapeutics Rheumatology/Immunology

Frankfurt am Main, Hesse, 60590, Germany

Location

Rheumazentrum Prof.Neeck MVZ

Bad Doberan, Mecklenburg-Vorpommern, 18209, Germany

Location

Universitaetsklinikum Koeln

Cologne, North Rhine-Westphalia, 50937, Germany

Location

Rheumazentrum Ratingen Studienambulanz

Ratingen, North Rhine-Westphalia, 40878, Germany

Location

Institut für Präventive Medizin & Klinische Forschung GbR

Magdeburg, Saxony-Anhalt, 39110, Germany

Location

Praxis für Rheumatologie und Innere

Berlin, 12163, Germany

Location

Schlosspark Klinik

Berlin, 14059, Germany

Location

HRF II - Hamburger Rheuma Forschungszentrum II MVZ für Rheumatologie und Autoimmunmedizin Hamburg GmbH / -T

Hamburg, 20095, Germany

Location

Hamburger Rheuma Forschungszentrum I / Dres Raabe & Heintz

Hamburg, 22391, Germany

Location

Attikon General University Hospital

Chaïdári, Attikí, 12462, Greece

Location

Ippokrateio General Hospital of Thessaloniki

Thessaloniki, Kentrikí Makedonía, 54642, Greece

Location

University Hospital of Alexandroupolis

Alexanroupolis, Évros, 68100, Greece

Location

CRU Hungary Kft.

Miskolc, Borsod-Abauj Zemplen county, 3529, Hungary

Location

Revita Clinic

Budapest, Pest County, 1027, Hungary

Location

Clinexpert Kft.

Budapest, Pest County, 1033, Hungary

Location

Vital Medical Center

Veszprém, Veszprém City, 8200, Hungary

Location

Debreceni Egyetem - Kenézy Gyula Egyetemi Oktatókórház

Debrecen, 4031, Hungary

Location

Debreceni Egyetem Klinikai Kozpont

Debrecen, 4032, Hungary

Location

Meir Medical Center

Kfar Saba, Central District, 4428164, Israel

Location

Sheba Medical Center

Ramat Gan, Central District, 5262100, Israel

Location

Barzilai Medical Center

Ashkelon, Southern District, 7830604, Israel

Location

Sourasky Medical Center

Tel Aviv, Tell Abīb, 6423906, Israel

Location

Rambam Health Care Campus

Haifa, Ḥeifā, 3109601, Israel

Location

Carmel Hospital

Haifa, Ḥeifā, 3436212, Israel

Location

Bnai Zion Medical Center

Haifa, Ḥeifā, Israel

Location

Clinical Research Center - Universita Degli Studi Gabriele d'Annunzio

Chieti, Abruzzo, 66013, Italy

Location

Ospedale Luigi Sacco

Milan, Milano, 20157, Italy

Location

Ospedale Le Scotte

Siena, Tuscany, 53100, Italy

Location

Azienda Ospedaliera Universitaria Careggi

Florence, 50141, Italy

Location

University of Campania Luigi Vanvitelli

Napoli, 80131, Italy

Location

Policlinico GB Rossi Borgo Roma

Verona, 37100, Italy

Location

Republican Hospital of Kaunas

Kaunas, Kauno Miestas, 45130, Lithuania

Location

Centro poliklinika

Vilnius, 01117, Lithuania

Location

Respublikin Šiauli ligonin

Šiauliai, Šiauliai County, 76231, Lithuania

Location

PT&R / PreCare Trial & Recruitment

Born, Limburg, 6121 XK, Netherlands

Location

Medische Centrum Leeuwarden

Leeuwarden, Provincie Friesland, 8934 AD, Netherlands

Location

Ai Centrum Medyczne Sp. Z O.O.

Poznan, Greater Poland Voivodeship, 61-113, Poland

Location

Prywatna Praktyka Lekarska Prof. UM dr hab. med. Pawel Hrycaj

Poznan, Greater Poland Voivodeship, 61-397, Poland

Location

Szpital Uniwersytecki Nr 2 w Bydgoszczy, Klinika Reumatologii i Ukladowych Chorób Tkanki Lacznej

Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-168, Poland

Location

MICS Centrum Medyczne Torun

Torun, Kuyavian-Pomeranian Voivodeship, 87-100, Poland

Location

Samodzielny Publiczny Zespol Opieki Zdrowotnej W Tomaszowie Lubelskim

Tomaszów Lubelski, Lublin Voivodeship, 22-600, Poland

Location

Twoja Przychodnia Centrum Medyczne Nowa Sol

Nowa Sól, Lubusz Voivodeship, 67-100, Poland

Location

NZOZ Lecznica MAK-MED s.c.

Nadarzyn, Masovian Voivodeship, 05-830, Poland

Location

Medycyna Kliniczna

Warsaw, Masovian Voivodeship, 00-874, Poland

Location

Rheuma Medicus- Zak��ad Opieki Zdrowotnej

Warsaw, Masovian Voivodeship, 02-118, Poland

Location

Centrum Medyczne Reuma Park

Warsaw, Masovian Voivodeship, 02-665, Poland

Location

ETG Warszawa

Warsaw, Masovian Voivodeship, 02-677, Poland

Location

Centrum Medyczne AMED Warszawa Targowek

Warsaw, Masovian Voivodeship, 03-291, Poland

Location

Osteo Medic sc A. Racewicz, J. Supronik

Bialystok, Podlaskie Voivodeship, 15-351, Poland

Location

Centrum Badan Klinicznych PI-House sp. z o.o.

Gdansk, Pomeranian Voivodeship, 80-546, Poland

Location

BIF-MED

Bytom, Silesian Voivodeship, 41-902, Poland

Location

Centrum Medyczne Pratia Katowice

Katowice, Silesian Voivodeship, 40-081, Poland

Location

Slaskie Centrum Reumatologii, Rehabilitacji I Zapobiegania Niepelnosprawnosci Im. Gen.J.Zietka

Ustroń, Silesian Voivodeship, 43-450, Poland

Location

Ambulatorium Barbara Bazela

Elblag, Warmian-Masurian Voivodeship, 82-300, Poland

Location

Centro Reumatologico Caguas

Caguas, 00725, Puerto Rico

Location

Ponce Medical School Foundation Inc.

Ponce, 00716, Puerto Rico

Location

Latin Clinical Trial Center

San Juan, 00909, Puerto Rico

Location

GCM Medical Group, PSC - Hato Rey Site

San Juan, 00917, Puerto Rico

Location

Mindful Medical Research

San Juan, 00918, Puerto Rico

Location

C.M.D.T.A. Neomed

Brasov, Brașov County, 500283, Romania

Location

Cmi Cristei Dorica

Brăila, Brăila County, 810019, Romania

Location

Spital Clinic Sf. Maria

Bucharest, București, 011172, Romania

Location

Delta Health Care

Bucharest, București, 014142, Romania

Location

CCBR Clinical Research

Bucharest, București, 30463, Romania

Location

Spitalul Clinic Judetean de Urgenta Sf. Apostol Andrei

Galati, Galați County, 800578, Romania

Location

RK Medcenter

Iași, Iaşi, 707027, Romania

Location

Spitalul Judeean de Urgen Dr. Constantin Opri Baia Mare

Baia Mare, Maramureş, 430031, Romania

Location

Sc Medaudio-Optica Srl

Râmnicu Vâlcea, Vâlcea County, 240762, Romania

Location

Kursk Regional Clinical Hospital

Kursk, Kursk Oblast, 305007, Russia

Location

Gbuz Lokb

Saint-Petersburg, Leningradskaya Oblast', 194291, Russia

Location

Moscow Clinical Research Center

Moscow, Moscow, 111123, Russia

Location

Federal State Budgetary Scientific Institution Research Institute Rheumatology named after V.A.Nasonova

Moscow, Moscow, 115522, Russia

Location

M. F. Vladimirskiy Moscow Regional Research Clinical Institute

Moscow, Moscow, 129110, Russia

Location

First Moscow State Medical University I.M. Sechenov

Moscow, Moscow Oblast, 119991, Russia

Location

Nizhny Novgorod City Clinical Hospital Number 5

Nizhny Novgorod, Nizhny Novgorod Oblast, 603005, Russia

Location

Ryazan Regional Clinical Cardiological Dispensary

Ryazan, Ryazan Oblast, 390026, Russia

Location

Clinical Rheumatology hospital #25

Saint Petersburg, Sankt-Peterburg, 190068, Russia

Location

North-Western State Medical University named after I.I.Mechnikov

Saint Petersburg, Sankt-Peterburg, 191015, Russia

Location

Tula Regional Clinical Hospital

Tula, Tula Oblast, 300053, Russia

Location

GUZ UOKB

Ulyanovsk, Ulyanovsk Oblast, 432063, Russia

Location

Karelia Republican Hospital V.A. Baranova

Petrozavodsk, 185019, Russia

Location

Regional Clinical Hospital of the Saratov Region

Saratov, 410053, Russia

Location

Research & Practice

Yaroslavl, 150003, Russia

Location

ALBAMED s.r.o.

Zvolen, Banská Bystrica Region, 960 01, Slovakia

Location

ROMJAN s.r.o.

Bratislava, Bratislava Region, 851 01, Slovakia

Location

Artromac n.o.

Košice, Košice Region, 040 11, Slovakia

Location

REUMED s.r.o.

Spišská Nová Ves, Košice Region, 05201, Slovakia

Location

LERAM s.r.o.

Topoľčany, Nitra Region, 955 01, Slovakia

Location

Reumacentrum s.r.o.

Partizánske, Trenčín Region, 958 01, Slovakia

Location

Netcare Greenacres Hospital

Port Elizabeth, Eastern Cape, 6045, South Africa

Location

FARMOVS

Bloemfontein, Free State, 9301, South Africa

Location

Iatros International

Bloemfontein, Free State, 9301, South Africa

Location

Clinresco Centres

Kempton Park, Gauteng, 1619, South Africa

Location

University of Pretoria - Faculty of Health Sciences

Pretoria, Gauteng, 0001, South Africa

Location

Precise Clinical Solutions

Chatsworth, KwaZulu-Natal, 4092, South Africa

Location

Netcare Umhlanga Hospital

Umhlanga, KwaZulu-Natal, 4320, South Africa

Location

Arthritis Clinical Trial Centre

Cape Town, Western Cape, 7405, South Africa

Location

Winelands Medical Research Centre

Stellenbosch, Western Cape, 7600, South Africa

Location

Complejo Hospitalario Universitario A Coruña

A Coruña, A Coruña [La Coruña], 15006, Spain

Location

Clínica Gaias - Santiago

Santiago de Compostela, A Coruña [La Coruña], 15702, Spain

Location

Hospital General Universitario de Elche

Elche, Alicante, 03202, Spain

Location

Hospital Marina Baixa

Villajoyosa, Alicante, 03570, Spain

Location

Osi Bilbao-Basurto

Bilbao, Basque Country, 48013, Spain

Location

Clínica Sagrada Familia

Barcelona, Catalunya [Cataluña], 08022, Spain

Location

Hospital Quiron Barcelona

Barcelona, Catalunya [Cataluña], 08023, Spain

Location

Hospital Clínic de Barcelona

Barcelona, Catalunya [Cataluña], 08036, Spain

Location

Corporació Sanitària Parc Taulí

Sabadell, Catalunya [Cataluña], 08208, Spain

Location

Consorci Sanitari Integral. Hospital Moisés Broggi, Sant Joan Despí

Sant Joan Despí, Catalunya [Cataluña], 08970, Spain

Location

Hu Reina Sofia

Córdoba, Córdoba, 14004, Spain

Location

CHUS - Hospital Clinico Universitario

Santiago de Compostela, Galicia [Galicia], 15706, Spain

Location

Hospital Universitario de Fuenlabrada

Fuenlabrada, Madrid, Comunidad de, 28944, Spain

Location

Hospital Universitario Getafe

Getafe, Madrid, Comunidad de, 28905, Spain

Location

Hospital Universitario Puerta de Hierro Majadahonda

Majadahonda, Madrid, Comunidad de, 28222, Spain

Location

CHUVI- Hospital do Meixoeiro

Vigo, Pontevedra [Pontevedra], 36200, Spain

Location

Hospital Quirónsalud Córdoba

Córdoba, 14004, Spain

Location

Hospital Universitario 12 de Octubre

Madrid, 28041, Spain

Location

Hospital Universitario La Paz

Madrid, 28046, Spain

Location

Hospital Universitario Virgen Macarena

Seville, 41009, Spain

Location

Hospital Quiron Infanta Luisa

Seville, 41010, Spain

Location

University Hospital Basel

Basel, Canton of Basel-City, 4056, Switzerland

Location

Cantonal Hospital St.Gallen

Sankt Gallen, Canton of St. Gallen, 9007, Switzerland

Location

HFR Fribourg - Hôpital Cantonal

Fribourg, 1708, Switzerland

Location

Eskisehir Osmangazi University

Eskişehir, Eskişehir, 26480, Turkey (Türkiye)

Location

Marmara Universitesi Pendik Egitim Arastirma Hastanesi

Stanbul, Istanbul, 34899, Turkey (Türkiye)

Location

Trakya University

Edirne, 22030, Turkey (Türkiye)

Location

Istanbul University Cerrahpasa Medical School Internal Diseases Institute

Istanbul, 34098, Turkey (Türkiye)

Location

Izmir Katip Celebi Ataturk Egitim Arastirma Hastanesi

Izmir, 35620, Turkey (Türkiye)

Location

Necmettin Erbakan Meram Medical Fac.

Konya, Turkey (Türkiye)

Location

Christchurch Hospital

Christchurch, Bournemouth, BH23 2JX, United Kingdom

Location

Derriford Hospital

Plymouth, Devon, Pl6 8DH, United Kingdom

Location

Torbay Hospital

Torquay, Devon, TQ2 7AA, United Kingdom

Location

The Dudley Group NHS Foundation Trust

Dudley, England, DY1 2HQ, United Kingdom

Location

Royal Free London NHS Foundation Trust

London, England, NW32QG, United Kingdom

Location

The Royal Cornwall Hospital

Truro, England, TR1 3LJ, United Kingdom

Location

Mid Essex Hospital Services NHS Trust

Chelmsford, Essex, CM1 7ET, United Kingdom

Location

Queen Alexandra Hospital

Portsmouth, Hampshire, PO6 3LY, United Kingdom

Location

Hull and East Yorkshire Hospitals NHS Trust

Hull, Kingston Upon Hull, HU3 2JZ, United Kingdom

Location

Northumbria Healthcare NHS Foundation Trust

Newcastle upon Tyne, North Tyneside, NE29 8NH, United Kingdom

Location

King's Mill Hospital

Sutton in Ashfield, Nottinghamshire, NG17 4JL, United Kingdom

Location

Barts Health NHS Trust - Whipps Cross University Hospital

London, Waltham Forest, E11 1NR, United Kingdom

Location

Aintree University Hospital NHS Foundation Trust

Liverpool, L9 7AL, United Kingdom

Location

New Cross Hospital

Wolverhampton, WV10 0QP, United Kingdom

Location

Related Links

MeSH Terms

Conditions

Arthritis, Rheumatoid

Interventions

baricitinibTumor Necrosis Factor InhibitorsEtanerceptAdalimumab

Condition Hierarchy (Ancestors)

ArthritisJoint DiseasesMusculoskeletal DiseasesRheumatic DiseasesConnective Tissue DiseasesSkin and Connective Tissue DiseasesAutoimmune DiseasesImmune System Diseases

Intervention Hierarchy (Ancestors)

Anti-Inflammatory AgentsTherapeutic UsesPharmacologic ActionsChemical Actions and UsesImmunoglobulin Fc FragmentsImmunoglobulin FragmentsPeptide FragmentsPeptidesAmino Acids, Peptides, and ProteinsImmunoglobulin Constant RegionsImmunoglobulinsImmunoproteinsBlood ProteinsProteinsSerum GlobulinsGlobulinsReceptors, Tumor Necrosis FactorReceptors, CytokineReceptors, ImmunologicReceptors, Cell SurfaceMembrane ProteinsAntibodies, Monoclonal, HumanizedAntibodies, MonoclonalAntibodies

Study Officials

  • Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST)

    Eli Lilly and Company

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
phase 4
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

April 12, 2019

First Posted

April 16, 2019

Study Start

April 25, 2019

Primary Completion

May 28, 2025

Study Completion

May 28, 2025

Last Updated

July 22, 2025

Record last verified: 2025-07

Data Sharing

IPD Sharing
Will share

Anonymized individual patient level data will be provided in a secure access environment upon approval of a research proposal and a signed data sharing agreement.

Shared Documents
STUDY PROTOCOL, SAP, CSR
Time Frame
Data are available 6 months after the primary publication and approval of the indication studied in the US and EU, whichever is later. Data will be indefinitely available for requesting.
Access Criteria
A research proposal must be approved by an independent review panel and researchers must sign a data sharing agreement.
More information

Locations