Effect of Oral Feeding on Gastric Emptying, Gut Blood Flow, and Hormone Responses in Obese and Healthy Weight Subjects

NCT03860623 | Completed

• 1 other identifier: A16042015
• Study Type: observational
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Obesity is a complicated condition that is poorly understood. The aim of this study is to increase our knowledge of how the condition may arise, and what makes obese people remain obese. We will be investigating 12 people who are overweight and comparing them to 12 people who are lean, to look at how quickly food empties out of the stomach (gastric emptying) and travels through the gut, what the blood flow to the gut is, and also to examine the hormones which are involved in determining how full people feel after eating. In order to do this, we will be using a magnetic resonance imaging (MRI) scanner, and performing blood tests. The rate of gastric emptying may have an impact on satiety (how full one feels) and has been implied in the development of obesity. This effect has been shown to impact on subsequent meal intake to a greater degree in overweight subjects, and may be due to a difference in gastric emptying of food in overweight individuals, or to hormones such as ghrelin, glucagon-like peptide 1, and Peptide YY.

Conditions

Obesity

Keywords

satiety; gut blood flow; gastric emptying; obesity; incretin hormones

Outcome Measures

Primary Outcomes (1)

• Gastric emptying rate

  time taken for a standard meal to empty from the stomach, assessed by serial volume measurements of the stomach using magnetic resonance imaging

  240 minutes after feeding

Secondary Outcomes (23)

• Stomach volume in the fasted state

  baseline

• Superior mesenteric artery (SMA) blood flow in the fasted state

  baseline

• superior mesenteric artery (SMA) blood flow response to feeding

  240 minutes after feeding

• Fasting blood glucose concentration

  before feeding

• Blood glucose response to feeding

  300 minutes after feeding

Study Arms (2)

Overweight

Otherwise healthy overweight and obese men (BMI 30-40kg/m2) aged 18 to 60 years Group will consume a standard meal (Feeding) and measurements will be made before (baseline) and for 300 minutes after eating

Normal Weight

Healthy normal weight men (BMI 18-25kg/m2, but including those with BMI up to 28kg/m2 if waist circumference \<96cm) aged 18 to 60 years Group will consume a standard meal (Feeding) and measurements will be made before (baseline) and for 300 minutes after eating

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Recruitment will be from the male population residing within 20 miles of the research site. This will include those from Nottinghamshire, Leicestershire and Derbyshire, UK

You may qualify if:

• BMI 30-40 kg/m2
• BMI 18-25 kg/m2; those with BMI up to 28kg/m2 will be included if waist circumference is \<96cm.
• Males
• Aged 18-60yrs

You may not qualify if:

• Acute illness in the preceding 6 weeks
• Taking regular medication
• History of deep vein thrombosis or clotting disorders
• Hypertension
• Diabetes
• Any clinically significant findings at screening
• History of substance abuse
• Demonstrating factors precluding safe MRI
• History of gastrointestinal motility disorders (e.g. gastroesophageal reflux disease -irritable bowel syndrome, gastroparesis, sphincter of Oddi dysfunction, etc.)
• Previous thoracic or abdominal surgery.
• Those who report having ≤3 bowel movements/week or \>2/day.

Sponsors & Collaborators

• University of Nottingham: lead

Study Sites (1)

Queens Medical Centre

Nottingham, Notts, NG72UH, United Kingdom

Location

Related Publications (6)

• Fu XY, Li Z, Zhang N, Yu HT, Wang SR, Liu JR. Effects of gastrointestinal motility on obesity. Nutr Metab (Lond). 2014 Jan 7;11(1):3. doi: 10.1186/1743-7075-11-3.

  PMID: 24398016 BACKGROUND

• Vatner SF, Franklin D, Van Citters RL. Mesenteric vasoactivity associated with eating and digestion in the conscious dog. Am J Physiol. 1970 Jul;219(1):170-4. doi: 10.1152/ajplegacy.1970.219.1.170. No abstract available.

  PMID: 4393203 BACKGROUND

• Alyami J, Spiller RC, Marciani L. Magnetic resonance imaging to evaluate gastrointestinal function. Neurogastroenterol Motil. 2015 Dec;27(12):1687-92. doi: 10.1111/nmo.12726.

  PMID: 26598049 BACKGROUND

• Hoad CL, Parker H, Hudders N, Costigan C, Cox EF, Perkins AC, Blackshaw PE, Marciani L, Spiller RC, Fox MR, Gowland PA. Measurement of gastric meal and secretion volumes using magnetic resonance imaging. Phys Med Biol. 2015 Feb 7;60(3):1367-83. doi: 10.1088/0031-9155/60/3/1367. Epub 2015 Jan 16.

  PMID: 25592405 BACKGROUND

• Totman JJ, Marciani L, Foley S, Campbell E, Hoad CL, Macdonald IA, Spiller RC, Gowland PA. Characterization of the time course of the superior mesenteric, abdominal aorta, internal carotid and vertebral arteries blood flow response to the oral glucose challenge test using magnetic resonance imaging. Physiol Meas. 2009 Oct;30(10):1117-36. doi: 10.1088/0967-3334/30/10/011. Epub 2009 Sep 16.

  PMID: 19759401 BACKGROUND

• Simpson EJ, Althubeati S, Cordon S, Hoad C, Bush D, Eldeghaidy S, Gowland PA, Macdonald IA, Lobo DN. The effect of oral feeding on gastrointestinal function, motility and appetite-regulating hormones, insulin, glucose and satiety in normal weight individuals and those with obesity. Clin Nutr. 2025 Sep;52:62-71. doi: 10.1016/j.clnu.2025.07.008. Epub 2025 Jul 8.

  PMID: 40714600 RESULT

Related Links

• WHO estimation of Global Overweight and Obesity

MeSH Terms

Conditions

Obesity

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Dileep Lobo, MD, PhD

  University of Nottingham

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Senior Research Fellow

Study Record Dates

• First Submitted: February 25, 2019
• First Posted: March 4, 2019
• Study Start: November 7, 2018
• Primary Completion: December 31, 2021
• Study Completion: October 28, 2022
• Last Updated: December 4, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)