Neurofeedback Improves Cognitive Performance and EEG Activity in Elderly With Mild Cognitive Impairment

NCT03855319 | Completed

• 1 other identifier: LUS3EEGNF
• Study Type: interventional
• Target: 20
• Locations: 0 countries
• Sites: N/A

Brief Summary

This is a non-pharmacological pilot study showing the improvement of a SMR/theta neurofeedback training program on cognitive performance and EEG activity in Elderly with Mild Cognitive Impairment.

Conditions

Mild Cognitive Impairment

Keywords

Neurofeedback; Electroencephalography; MCI; Alzheimer

Outcome Measures

Primary Outcomes (1)

• Rey Auditory Verbal Learning test

  Assessment of verbal learning in episodic memory, evaluating the ability to encode, combine, store and long-term consolidation process.

  Assessment at baseline, change from baseline to 11 weeks immediately after the NF training and 1 month follow-up

Secondary Outcomes (1)

• Relative power for delta, theta, alpha, sensorimotor and lower beta frequency bands.

  Assessment at baseline, change from baseline to 11 weeks immediately after the NF training and 1 month follow-up

Study Arms (1)

SMR neurofeedback training to MCI

EXPERIMENTAL

A sensorimotor/theta neurofeedback training consisted of 20 individuals sessions, twice a week during 11 weeks maximum. For each subject, NF was planned and conducted by a neuropsychologist experienced in neurophysiology an neurofeedback. Each session lasted 1h10 minutes and was conducted as follows: * Preparation and installation of the electrodes, verification of the impedance, adjustement of the calibration. * NF training (tasks and video described below)(45minutes) * Feedback and debriefing about the session (15 minutes)

Behavioral: SMR neurofeedback training to MCI

Interventions

SMR neurofeedback training to MCI BEHAVIORAL

The intervention consisted to increase the synaptic strengths and sensitivity within this network. Electroencephalography signals for SMR/theta training was recorded at channel Cz according to the international 10-20 system. Theta rhythm was also recorded and, in this case, SMR was stimulated while theta waves were suppressed.A 32 channels system (EEGDigitrcak Biofeedback plus module, Inc Elmiko Medical) was used for the SMR/theta Neurofeedback training.

Also known as: SMR, neurofeedback

SMR neurofeedback training to MCI

Eligibility Criteria

• Age: 65 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)

You may qualify if:

• Clinical diagnosis of Mild Cognitive Impairment
• education level of 9 years of studies minimum
• righthandedness
• subjective memory complaint confirmed by an informant
• a Mini Mental Status Examination score \>20.
• preserve activity of daily living and absence of dementia.

You may not qualify if:

• elderly persons who were under guardianship
• resident in nursing facilities
• neurological disease, psychiatric disease
• and involved in another cogniitve intervention.

Sponsors & Collaborators

• Fabienne Marlats: lead

MeSH Terms

Conditions

Cognitive Dysfunction

Interventions

Neurofeedback

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Biofeedback, Psychology; Mind-Body Therapies; Complementary Therapies; Therapeutics; Behavior Therapy; Psychotherapy; Behavioral Disciplines and Activities; Feedback, Psychological

Study Officials

• anne-Sophie AR Rigaud, Professor

  Study Principal Investigator

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Neuropsychologist

Model Details: no randomized, no controlled

Study Record Dates

• First Submitted: February 25, 2019
• First Posted: February 26, 2019
• Study Start: December 15, 2016
• Primary Completion: December 15, 2018
• Study Completion: December 15, 2018
• Last Updated: February 28, 2019

Record last verified: 2019-02

Data Sharing

• IPD Sharing: Will not share