The Effects of Exercise on Executive Functions

NCT03852368 | Withdrawn

• 1 other identifier: 2017-3836
• Study Type: interventional
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this research is to develop an assessment protocol that can be used to study the effect of different intensities of exercise on executive functions (EF: attention, working memory, inhibition, and cognitive flexibility). It has been shown that exercise has the potential to improve the development of EF in healthy and special needs children. However, many exercise interventions in the literature lack rigorous control of critical components, such as intensity, making it difficult to draw conclusions about what type and how much exercise might be most beneficial for EF. In addition, to date, no studies have been able to demonstrate the engagement of EF during exercise. This study will focus on developing an assay that measures important self-regulation or EF sub-processes (e.g., attention and inhibitory control) as well as examining engagement of these targets during different exercise intensities. Participants will exercise in different intensities on a cycle ergometer and perform cognitive assessments before, during, and after exercise to evaluate EF. This research will allow us to develop an assessment protocol that can be used in future research to understand the underlying mechanisms underpinning the effects of exercise on EF.

Conditions

The Effects of Exercise on Executive Functions

Outcome Measures

Primary Outcomes (4)

• The Effects of Light, Moderate and Heavy Exercise on Attention

  Attention will be tested with the Hearts and Flowers test

  4 weeks

• The Effects of Light, Moderate and Heavy Exercise on Working Memory

  Working Memory will be tested with the Hearts and Flowers test

  4 weeks

• The Effects of Light, Moderate and Heavy Exercise on Inhibition

  Inhibition will be tested with Stroop Color-Word test

  4 weeks

• The Effects of Light, Moderate and Heavy Exercise on Cognitive Flexibility

  Cognitive Flexibility will be tested with Stroop Color-Word test

  4 weeks

Secondary Outcomes (1)

• The Effects of Light, Moderate and Heavy Exercise on temporal dynamics of executive function processes

  4 weeks

Study Arms (3)

The Effects of Light Exercise in Executive Functions

EXPERIMENTAL

The effects of light exercise in executive functions of adolescents

Other: Exercise

The Effects of Moderate Exercise in Executive Functions

EXPERIMENTAL

The effects of moderate exercise in executive functions of adolescents

Other: Exercise

The Effects of Heavy Exercise in Executive Functions

EXPERIMENTAL

The effects of heavy exercise in executive functions of adolescents

Other: Exercise

Interventions

Exercise OTHER

The effects of exercise with different intensity on the executive functions of adolescents

The Effects of Heavy Exercise in Executive Functions; The Effects of Light Exercise in Executive Functions; The Effects of Moderate Exercise in Executive Functions

Eligibility Criteria

• Age: 10 Years - 15 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• Absence of health problems that would preclude participation in exercise
• Male or female between the ages of 10-15 years inclusive at the time of consent
• Minimum level of intellectual functioning, as determined by an IQ (based on cognitive testing) score of 80 or above
• Ability to complete EF testing in English

You may not qualify if:

• Other limitations which in the opinion of a physician would preclude ability to perform exercise testing
• Use of illegal drugs or abuse of alcohol based on self-report during screening (this will occur during the one-on-one brief psychological evaluation)
• Pregnancy or breastfeeding based on urine sample test

Sponsors & Collaborators

• University of California, Irvine: lead

Study Sites (1)

Pediatric Exercise and Genomics Research Center, University of California, Irvine

Irvine, California, 92697/92617, United States

Location

MeSH Terms

Interventions

Exercise

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 21, 2019
• First Posted: February 25, 2019
• Study Start: September 6, 2017
• Primary Completion: September 6, 2017
• Study Completion: September 6, 2017
• Last Updated: February 12, 2021

Record last verified: 2021-02

Locations

US (1)