Effects of a Warm-up on Immune Response to Exercise

NCT04868136 | Completed

• 1 other identifier: STUDY00000990
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

This randomized cross-over study compares two identical cardiorespiratory exercise bouts, differing only in the inclusion or exclusion of a dynamic period of increasing exercise intensity prior to the exercise bout. Planned comparisons include physiological responses and perceived effort during exercise, leukocyte mobilization, and mood between the two exercise sessions.

Conditions

Physiological and Psychological Responses to Exercise

Outcome Measures

Primary Outcomes (7)

• Heart rate during exercise

  Heart rate in beats per minute

  Minutes 1-30 of exercise, recordings made each minute

• Perceived exertion during exercise

  Rating of perceived exertion measured using the Borg 6-20 scale

  Minutes 1-30 of exercise, recordings made each minute

• Power during exercise

  Wattage produced on stationary bicycle

  Minutes 1-30 of exercise, recordings made each minute

• Monocyte mobilization by exercise

  Number of peripheral blood monocytes

  Change from resting levels of monocytes after exercise

• Natural Killer cell mobilization by exercise

  Number of peripheral blood natural killer cells

  Change from resting levels of natural killer cells after exercise

• CD4 T cell mobilization by exercise

  Number of peripheral blood CD4 T cells

  Change from resting levels of CD4 T cells after exercise

• CD8 T cell mobilization by exercise

  Number of peripheral blood CD8 T cells

  Change from resting levels of CD8 T cells after exercise

Secondary Outcomes (2)

• Mood after exercise

  Measured within 10 minute of end of exercise session

• Affect after exercise

  Measured within 10 minute of end of exercise session

Study Arms (2)

Warm-up, then no warm-up

EXPERIMENTAL

Participants' visit 2 included 10 minutes of gradually increasing intensity prior to the 30 minute exercise session. Participants' visit 3 consisted of the 30 minute exercise session without a warm-up.

Behavioral: Exercise

No warm-up, then warm-up

EXPERIMENTAL

Participants' visit 2 consisted of the 30 minute exercise session without a warm-up. Participants' visit 3 included 10 minutes of gradually increasing intensity prior to the 30 minute exercise session.

Behavioral: Exercise

Interventions

Exercise BEHAVIORAL

30 minutes of exercise at 80% of maximum predicted heart rate performed on an indoor stationary bicycle. Exercise was preceded by 10 min of gradually increasing cycling intensity in one of two exercise trials

Also known as: Cardiorespiratory exercise

No warm-up, then warm-up; Warm-up, then no warm-up

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• identifies as exercising 1-3 hours per week or more than 6 hours per week, on average (last 6 months)
• meets American College of Sports Medicine criteria for participation in exercise

You may not qualify if:

• underlying medical problems that contraindicate supervised high intensity exercise
• past or present history of autoimmune disease, HIV, hepatitis, stroke, or cardiovascular disease
• chronic/debilitating arthritis
• central or peripheral nervous disorders
• asthma, emphysema, or bronchitis
• bedridden in the past three months
• history of blood clotting disorders
• administration of any medication that might affect physiological response to exercise
• functional or cognitive impairment that would limit exercise performance or prohibit informed consent
• having any common-cold or influenza like symptoms (scratchy throat, runny nose, inflamed sinuses, frequent sneezing or coughing) in the last 2 weeks
• pregnancy
• tobacco use

Sponsors & Collaborators

• University of Houston: lead

Study Sites (1)

University of Houston

Houston, Texas, 77204, United States

Location

MeSH Terms

Interventions

Exercise

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Emily C LaVoy, PhD

  University of Houston

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Profesor

Model Details: Randomized cross-over study with two conditions. Randomization was stratified by sex

Study Record Dates

• First Submitted: April 25, 2021
• First Posted: April 30, 2021
• Study Start: July 15, 2018
• Primary Completion: February 1, 2020
• Study Completion: September 30, 2021
• Last Updated: May 17, 2022

Record last verified: 2022-05

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF, CSR
• Time Frame: Will be available upon publication
• Access Criteria: Requests should be sent to and will be reviewed by the principle investigator

Locations

US (1)