Correlation Between End-tidal CO2 and Degree of Compression of Heart During CPR Measured by Ultrasound

NCT03852225 | Unknown

• 1 other identifier: 2018-02
• Study Type: observational
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Individual optimization of cardiopulmonary resuscitation (CPR) in real time may increase the success rate of the procedure. End-tidal CO2 (EtCO2) levels reflect cardiac output induced by CPR. Other potential marker of haemodynamic efficacy of CPR is direct measurement of the extent of induced compression of left ventricle (LV), right ventricle (RV) and inferior caval vein (IVC) by ultrasound. We plane to evaluate whether these ultrasound parameters correlate with EtCO2 levels during CPR for out-of-hospital cardiac arrest (OHCA) of non-traumatic origin.

Conditions

Cardiopulmonary Resuscitation; Echocardiography

Outcome Measures

Primary Outcomes (1)

• Correlation of EtCO2 level and compression index of left ventricle, right ventricle and inferior caval vein

  Compression index of left ventricle, right ventricle and inferior caval vein measured by intra-arrest echocardiography and EtCO2 measured by side stream approach during cardiopulmonary resuscitation.

  Participant will be repeatedly evaluated during cardiopulmonary resuscitation. Therefore, anticipated time frame the time interval will fluctuate from 5 minutes to 120 minutes

Study Arms (1)

OHCA patients

Patients resuscitated for out-of-hospital cardiac arrest of non-traumatic origin and investigated by intra-arrest echocardiography.

Diagnostic Test: Intra-arrest echocardiography

Interventions

Intra-arrest echocardiography DIAGNOSTIC_TEST

Intra-arrest echocardiography performed by portable ultrasound device during ongoing chest compressions.

OHCA patients

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All consecutive patients meeting inclusion and exclusion criteria

You may qualify if:

• Adult patient resuscitated for out-of-hospital cardiac arrest of non-traumatic origin.

You may not qualify if:

• Technical unavailability of intra-arrest ultrasonography and capnography.

Sponsors & Collaborators

• Emergency Medical Service of the Central Bohemian Region, Czech Republic: lead
• Masaryk Hospital Usti nad Labem: collaborator

Study Sites (1)

Emergency Medical Service of the Central Bohemian Region

Kladno, Central Bohemia, Czechia

RECRUITING

Related Publications (1)

• Skulec R, Vojtisek P, Cerny V. Correlation between end-tidal carbon dioxide and the degree of compression of heart cavities measured by transthoracic echocardiography during cardiopulmonary resuscitation for out-of-hospital cardiac arrest. Crit Care. 2019 Oct 29;23(1):334. doi: 10.1186/s13054-019-2607-2.

  PMID: 31665061 DERIVED

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Roman Skulec, MD, PhD

Study Record Dates

• First Submitted: February 21, 2019
• First Posted: February 25, 2019
• Study Start: January 1, 2018
• Primary Completion: March 15, 2019
• Study Completion: March 31, 2019
• Last Updated: February 25, 2019

Record last verified: 2019-02

Data Sharing

• IPD Sharing: Will not share

Locations

CZ (1)