Neuro-cognitive Impact of Juvenile Obesity

NCT03776513 | Terminated

• 1 other identifier: CHUBX 2017/19
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Recent studies indicate that obese teenagers exhibit memory disturbances. Adolescence represents a crucial period in the development of the hippocampus and the amygdala, necessary for the implementation of memory and emotional functions for the rest of life. Disturbances of the interaction between amygdala and hippocampus during adolescence have been associated with the development of neuropsychiatric disorders. However, the impact of juvenile obesity on functional amygdala-hippocampus connectivity has not been evaluated yet. The main objective of this study is to compare the emotional memory performance and the level of functional connectivity between the hippocampus and the amygdala during the realization of an emotional associative memory task, in obese and control adolescents.

Conditions

Behavior and Behavior Mechanisms; Emotions; Pediatric Obesity

Keywords

obesity, teenagers, emotional memory, brain networks

Outcome Measures

Primary Outcomes (1)

• the level of connectivity between the amygdala and the hippocampus recorded during the execution of an emotional memory task in the scanner.

  The level of connectivity between the hippocampus and the amygdala during the performance of the task will be measured through the fluctuations of the blood oxygen level-dependent (BOLD) signal obtained in activation functional magnetic resonance imaging (fMRI) during the performance of an associative emotional memory task. The level of functional connectivity between two brain regions will be deduced from the temporal correlation between the fluctuations of the BOLD signal between these two regions. This coefficient will be normalized in Z-score before analysis.

  through study completion, an average of 24 months

Secondary Outcomes (12)

• The level of connectivity between the amygdala and the hippocampus before and after the task will also be recorded at rest.

  through study completion, an average of 24 months

• The score at the emotional memory task performed in the scanner will be collected

  through study completion, an average of 24 months

• grey matter volumes (mm3)

  through study completion, an average of 24 months

• cortical thicknesses (mm)

  through study completion, an average of 24 months

• The percentage of body fat

  through study completion, an average of 24 months

Study Arms (2)

experimental group

EXPERIMENTAL

Thirty obese boys (12-17 years old) undergoing an MRI, a clinical and psychological examination and a series of cognitive tests

Behavioral: an MRI examination

control group

OTHER

Thirty healthy boys (12-17 years old) paired for pubertal stage, level of education and socio-economic level undergoing an MRI, a clinical and psychological examination and a series of cognitive tests

Behavioral: an MRI examination

Interventions

an MRI examination BEHAVIORAL

The MRI examination implies the realization of an emotional associative memory task

Also known as: a clinical and psychological examination and a series of cognitive tests

control group; experimental group

Eligibility Criteria

• Age: 12 Years - 17 Years
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• Experimental group: 12-17 years old boys, BMI\>30 (according to IOTF), right-handed, French secondary school, beneficiary of social security, consent of the holders of parental authority.
• Control group: 12-17 years old boys, BMI\<25 (according to IOTF), right-handed, French secondary school, beneficiary of social security, consent of the holders of parental authority.

You may not qualify if:

• Adolescent with pubertal stage of Tanner \<2
• Adolescent with known visual or auditory difficulties
• Adolescent with a known chronic pathology requiring medication
• Adolescent with psychotic, neurodevelopmental or substance use disorder
• Adolescent who may have a contraindication to the MRI examination (presence in the body of metallic prostheses, pacemaker, metal chips, claustrophobia).

Sponsors & Collaborators

• University Hospital, Bordeaux: lead
• Equipe NeuroImagerie et Cognition Humaine CNRS UMR 5287 - INCIA: collaborator
• University of Bordeaux: collaborator

Study Sites (1)

Bordeaux University Hospital

Bordeaux, 33079, France

Location

Related Publications (1)

• Vertes PE, Bullmore ET. Annual research review: Growth connectomics--the organization and reorganization of brain networks during normal and abnormal development. J Child Psychol Psychiatry. 2015 Mar;56(3):299-320. doi: 10.1111/jcpp.12365. Epub 2014 Dec 1.

  PMID: 25441756 RESULT

MeSH Terms

Conditions

Pediatric Obesity; Behavior; Obesity

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 7, 2018
• First Posted: December 14, 2018
• Study Start: December 12, 2018
• Primary Completion: February 19, 2020
• Study Completion: February 19, 2020
• Last Updated: June 23, 2026

Record last verified: 2018-11

Locations

FR (1)