Role of Mechanical Load on Metabolic Exercise Adaptations in Response to Weight Loss in Obese Adolescents: The POWELL Study

NCT04902001 | Completed

• 2 other identifiers: RBHP 2021 BOIRIE2021-A00756-35
• Study Type: interventional
• Target: 21
• Locations: 1 country
• Sites: 1

Brief Summary

While interdisciplinary weight loss intervention have been shown successful among adolescents with obesity, a weight regain is most of the time observed within the following weeks or months. The aim of the present project will be to better identify the independent role played by both the metabolic and mechanical load and their modification during weight loss, on the energy expenditure and energy metabolism of adolescents with obesity.

Conditions

Pediatric Obesity

Keywords

energy expenditure; weight loss; obesity; adolescents

Outcome Measures

Primary Outcomes (1)

• Change in Energy Expenditure between before and after weight loss

  amount of energy expended during the walking tests, measured using indirect calorimetry

  before and after the 12-week weight loss

Secondary Outcomes (5)

• change in lipid oxidation between before and after weight loss

  before and after the 12-week weight loss

• change in Fat mass between before and after weight loss

  before and after the 12-week weight loss

• change physical activity preferences between before and after weight loss

  before and after the 12-week weight loss intervention

• Change in Energy Expenditure between the unloaded and loaded walking test

  after the 12_week weight loss

• Change in lipid oxidation between the unloaded and loaded walking test

  after the 12_week weight loss

Study Arms (1)

Adolescents with obesity

EXPERIMENTAL

Adolescents with obesity aged 12-16 years old

Behavioral: Multidisciplinary weight loss

Interventions

Multidisciplinary weight loss BEHAVIORAL

The adolescents will follow a 12-week intervention combining nutritional education, physical activity 3 times per week and psychological supports.

Adolescents with obesity

Eligibility Criteria

• Age: 12 Years - 16 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)

You may qualify if:

• being aged 12-16 years old
• no contraindication to physical exercise
• no cardiovascular disease
• BMI above the 97th percentile
• candidate to a weight loss intervention

You may not qualify if:

• surgery and medical conditions preventing them to perform the intervention
• Weight loss during the previous 6 months
• medication that could interfere with energy metabolism.
• pregnancy
• regular tobacco and alcool use

Sponsors & Collaborators

• University Hospital, Clermont-Ferrand: lead

Study Sites (1)

CHU clermont-ferrand

Clermont-Ferrand, France

Location

MeSH Terms

Conditions

Pediatric Obesity; Weight Loss; Obesity

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Body Weight Changes

Study Officials

• Yves Boirie

  University Hospital, Clermont-Ferrand

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Masking Details: There is no need for masking here.
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: One group of adolescents with obesity

Study Record Dates

• First Submitted: May 3, 2021
• First Posted: May 26, 2021
• Study Start: August 20, 2021
• Primary Completion: April 25, 2022
• Study Completion: April 25, 2022
• Last Updated: June 3, 2022

Record last verified: 2022-06

Locations

FR (1)