The Critical Threshold of Pulse Oximetry Plethysmographic Waveform Parameters in High Quality CPR

NCT03754946 | Unknown

• 1 other identifier: 201502019
• Study Type: observational
• Target: 1,000
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to analyze the relationship of the area under the curve (AUC) and/or the amplitude (Amp) of pulse oximetry plethysmographic waveform (POP) with partial pressure of end-tidal carbon dioxide (PETCO2) which could be used to reflect its quality in cardiopulmonary resuscitation (CPR), and then to determine the critical threshold of POP parameters in high quality CPR.

Conditions

Cardiopulmonary Resuscitation

Keywords

cardiopulmonary resuscitation; pulse oximetry plethysmographic waveform; quality monitor; partial pressure of end-tidal carbon dioxide

Outcome Measures

Primary Outcomes (2)

• the cut-off value of POP parameters in High Quality CPR

  Describe the the cut-off value of POP parameters in High Quality CPR. Receiver operating curve analysis was performed to evaluate the accuracy in predicting return of spontaneous circulation (ROSC).

  one year

• Compare different predictors

  Area under curve (AUC) between potential predictors was compared by using a nonparametric test, and the optimal cutoff point was determined by estimating the Youden's index.

  one year

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients who were admitted to the participant hospitals and met the inclusion criteria were included in the study.

You may qualify if:

• Cardiac arrested
• The time from cardiac arrest to receiving basic life support is less than 10 minutes
• Get advanced life support (endotracheal intubation and PETCO2 monitoring)

You may not qualify if:

• Defuse CPR
• chronic obstructive pulmonary disease (COPD) with type II respiratory failure
• Terminal malignant tumors or terminal stage of other diseases
• Rib fracture
• Cardiac arrest caused by hemorrhagic shock pulmonary embolism and cardiac tamponade
• Sever anemia(HGB\<7g/dl)
• Untreated tension pneumothorax
• Tinea unguium, dyeing Fingernails and other factors affect the monitor of Pulse Oximetry Plethysmographic Waveform such vasculitis and Raynaud's phenomenon

Sponsors & Collaborators

• Peking Union Medical College Hospital: lead

Study Sites (1)

Peking Union Medical College Hospital

Beijing, 100730, China

RECRUITING

Central Study Contacts

Xuezhong Yu, MD

CONTACT

+86 010 69159142; yxzpumch@126.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 15, 2018
• First Posted: November 27, 2018
• Study Start: September 1, 2015
• Primary Completion: June 30, 2018
• Study Completion: December 31, 2018
• Last Updated: November 27, 2018

Record last verified: 2018-11

Locations

CN (1)