A Phase 1 Study of ZSP1602 in Participants With Advanced Solid Tumors

NCT03734913 | Unknown Phase 1

• 1 other identifier: ZSP1602-16-01
• Study Type: interventional
• Target: 65
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to evaluate the safety, tolerability and pharmacokinetics, and determine the maximum tolerated dose of ZSP1602 in participants with basal cell carcinoma, adenocarcinoma of esophagogastric junction, small cell lung cancer, neuroendocrine neoplasm and other advanced solid tumors.

Conditions

Basal Cell Carcinoma; Medulloblastoma; Adenocarcinoma of Esophagogastric Junction; Small Cell Lung Cancer; Neuroendocrine Neoplasm; Glioblastoma

Outcome Measures

Primary Outcomes (2)

• Dose-limiting Toxicity (DLT)

  To determine the DLT of ZSP1602 in advanced solid tumor participants accessed by CTCAE4.03

  At day 32 after first dosing.

• Maximum tolerated dose (MTD)

  The highest dose at the level with \<= 2/6 participants experienced DLT.

  At day 32 after first dosing.

Secondary Outcomes (8)

• Time to progression (TTP)

  From Screening, Day 28 of Cycle1 (28 days), then every 8 weeks, until disease progression or discontinuation from study (approximately 18 months or earlier if participants terminate from the study).

• Over all response (ORR)

  From Screening, Day 28 of Cycle1 (28 days), then every 8 weeks, until disease progression or discontinuation from study (approximately 18 months or earlier if participants terminate from the study).

• Cmax of ZSP1602

  Protocol-defined time points during Cycles 0 (4 days) and 1 (28 days) of treatment per participants.

• Tmax of ZSP1602

  Protocol-defined time points during Cycles 0 (4 days) and 1 (28 days) of treatment per participants.

• Cmin of ZSP1602

  Protocol-defined time points during Cycles 0 (4 days) and 1 (28 days) of treatment per participants.

Study Arms (3)

Part 1

EXPERIMENTAL

Participants with advanced solid tumors including basal cell carcinoma and medulloblastoma, regardless of SMO or Gli1 alteration status.

Drug: ZSP1602

Part 2 Cohort A

EXPERIMENTAL

Participants with Adenocarcinoma of Esophagogastric Junction with SMO or Gli1 protein overexpression alteration.

Drug: ZSP1602

Part 2 Cohort B

EXPERIMENTAL

Participants with basal cell carcinoma, small cell lung cancer, neuroendocrine neoplasm and glioblastoma with SMO or Gli1 protein overexpression alteration.

Drug: ZSP1602

Interventions

ZSP1602 DRUG

ZSP1602 capsules for oral administration

Part 1; Part 2 Cohort A; Part 2 Cohort B

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Participants are required to meet all the criteria below in order to be included in the trial:
• Male or female participants, aged 18 \~ 75 years.
• Confirmed diagnosis of advanced solid tumors by histological or cytological examination, Participants have no effective standard anticancer therapy available or is intolerant to standard anticancer therapy. For Part 1 Dose Ascending Stage, and Part 2 Dose expansion Stage:
• For Part 1: Advanced solid tumors including basal cell carcinoma and medulloblastoma, regardless of SMO or Gli1 alteration status.
• For Part 2: Participants will be enrolled into cohort A and cohort B. Cohort A: Participants with Adenocarcinoma of Esophagogastric Junction with SMO or Gli1 protein overexpression alteration. (IHC≥1%) Cohort B: Participants with basal cell carcinoma, small cell lung cancer, neuroendocrine neoplasm and glioblastoma with SMO or Gli1 protein overexpression alteration. (IHC≥1%)
• Eastern Cooperative Oncology Group (ECOG) performance status of 0-1.
• Participants with at least 1 measurable tumor lesion based on response evaluation criteria in solid tumors 1.1 (RECIST 1.1) and response assessment in neuro-oncology criteria (RANO) (participants with glioblastoma must accept skull MRI scanning.)
• Recovery from past medical history of adverse reactions (excluding alopecia and neurotoxicity) caused by radiotherapy and chemotherapy to national cancer institute common terminology criteria for adverse events 4.03 (NCI CTCAE 4.03) ≤Grade 1 or baseline level.
• Life expectancy \> 12 weeks.
• Adequate organ function, defined by the following laboratory results, to be obtained prior to registration and enrollment:
• Bone marrow function: absolute neutrophil count (ANC)≥1.5×10\^9/L; hemoglobin (HB)≥90 g/L; Platelet count (PLT)≥75×10\^9/L.
• Liver function: Alanine aminotransferase (ALT)≤2.5×the upper limit of normal (ULN), aspartate aminotransferase (AST)≤2.5×ULN, alkaline phosphatase (ALP)≤2.5×ULN, total bilirubin (TBIL)≤1.5×ULN; ALT≤5×ULN, AST≤5×ULN, ALP≤5×ULN (For participants with liver metastasis).
• Renal function: creatinine≤1.5×ULN; clearance (CL)≥ 60 mL/min. Coagulation function: international normalized ratio (INR)≤1.5×ULN, activated partial thromboplastin time (APTT)≤1.5×ULN.
• Left ventricular ejection fractions (LVEF)≥50%. Creatine kinase (CK)≤2.5×ULN.
• Participants (including partners) have no gestation plans and must use reliable methods of contraception during the study and until 8 months following the last dose of investigational product.

You may not qualify if:

• Participants who have intracranial tumor and/or brain metastases with clinical symptoms and need treatment are ineligible except for the following circumstances:
• recovery from the therapy (including radiotherapy and/or surgery) 4 weeks before enrollment.
• Participants with intracranial tumor who are clinically stable during screening and enrollment, have no need to medication by hormone or anticonvulsants, and are estimated to be clinically stable during the study.
• Participants with glioblastoma confirmed diagnosis via MRI or CT of intracranial hemorrhage and intratumor hemorrhage.
• Participants with positive human immunodeficiency virus(HIV) or hepatitis C virus antibody (HCV) or hepatitis B surface antigen (HBV DNA\>2.0 ×103 IU/ml) or active infections which require systematic antibiotics therapy or concurred with unexplainable fever before drug treatment.
• History of pulmonary fibrosis or interstitial pneumonia including pneumoconiosis and radiation pulmonary fibrosis beyond radiation field.
• Participants with dysphagia.
• Participants with incontrollable hydrops in third lumen such as malignant pleural effusion and ascites.
• Participants with Diarrhea \> Grade 2 (according to CTCAE 4.03)
• Any clinically significant gastrointestinal abnormalities, which may impair absorption of ZSP1602, such as Crohn's disease, ulcerative colitis and subtotal gastrectomy.
• Participants with major surgery or active peptic ulcer disease or unrecovered wound.
• History of myocardial infarction or congestive heart-failure (CHF) at NYHA≥3 level within 6 months prior to enrollment.
• Has either a history of uncontrollable or unstable angina pectoris or a history of severe or uncontrollable ventricular arrhythmia.
• Participants with QTcF prolongations in electrocardiogram (ECG) baseline (QTcF\>450ms for males or QTcF\>470ms for females) or with high risk factors leading to QT intervals prolonging (including hypokalemia, familial QT interval prolongation syndrome).
• Participants with concomitant illness such as hemorrhagic or thrombotic diseases or with anticoagulant treatment in routine dose for the moment.

Sponsors & Collaborators

• Guangdong Zhongsheng Pharmaceutical Co., Ltd.: lead

Study Sites (1)

Jilin Cancer Hospital

Changchun, Jilin, 130000, China

RECRUITING

MeSH Terms

Conditions

Carcinoma, Basal Cell; Medulloblastoma; Small Cell Lung Carcinoma; Neuroendocrine Tumors; Glioblastoma

Condition Hierarchy (Ancestors)

Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; Neoplasms; Neoplasms, Basal Cell; Glioma; Neoplasms, Neuroepithelial; Neuroectodermal Tumors; Neoplasms, Germ Cell and Embryonal; Neuroectodermal Tumors, Primitive; Neoplasms, Nerve Tissue; Carcinoma, Bronchogenic; Bronchial Neoplasms; Lung Neoplasms; Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Lung Diseases; Respiratory Tract Diseases; Astrocytoma

Central Study Contacts

Ying Cheng, MD

CONTACT

+8643185871902; jl.cheng@163.com

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 5, 2018
• First Posted: November 8, 2018
• Study Start: January 25, 2019
• Primary Completion: July 31, 2021
• Study Completion: July 31, 2021
• Last Updated: July 22, 2020

Record last verified: 2020-07

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)