Key Insights

Highlights

Success Rate

76% trial completion

Published Results

148 trials with published results (17%)

Research Maturity

343 completed trials (39% of total)

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 59/100

Termination Rate

12.4%

108 terminated out of 873 trials

Success Rate

76.1%

-10.5% vs benchmark

Late-Stage Pipeline

6%

50 trials in Phase 3/4

Results Transparency

43%

148 of 343 completed with results

Key Signals

148 with results76% success108 terminated

Data Visualizations

Phase Distribution

750Total
Not Applicable (128)
Early P 1 (48)
P 1 (291)
P 2 (233)
P 3 (45)
P 4 (5)

Trial Status

Completed343
Recruiting154
Terminated108
Active Not Recruiting92
Unknown81
Not Yet Recruiting50

Trial Success Rate

76.1%

Benchmark: 86.5%

Based on 343 completed trials

Clinical Trials (873)

Showing 20 of 20 trials
NCT05557292Phase 1TerminatedPrimary

RMC-5552 Monotherapy in Adult Subjects With Recurrent Glioblastoma

NCT06804655Phase 2Not Yet Recruiting

Pharmacoscopy for Patients With Refractory Primary Brain Tumors

NCT04699773Not ApplicableRecruiting

LITT Followed by Hypofractionated RT for Newly Diagnosed Gliomas (GCC 20138)

NCT07568782Not Yet RecruitingPrimary

Impact of Fluorescence-Guided Resection and Chemoradiotherapy on the Systemic Immune Response in Glioblastoma: A Kinetic Analysis of Immune Biomarkers.

NCT05095376Phase 3Active Not RecruitingPrimary

Testing the Addition of the Chemotherapy Drug Lomustine (Gleostine) to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Methylated Glioblastoma

NCT05835687Phase 1Recruiting

Loc3CAR: Locoregional Delivery of B7-H3-CAR T Cells for Pediatric Patients With Primary CNS Tumors

NCT03975829Phase 4Recruiting

Pediatric Long-Term Follow-up and Rollover Study

NCT05629702Phase 2RecruitingPrimary

ARISTOCRAT: Blinded Trial of Temozolomide +/- Cannabinoids

NCT03970447Phase 2RecruitingPrimary

A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma

NCT05241392Phase 1Active Not RecruitingPrimary

Safety and Efficacy Study of Anti-B7-H3 CAR-T Cell Therapy for Recurrent Glioblastoma

NCT03491683Phase 1Active Not RecruitingPrimary

INO-5401 and INO-9012 Delivered by Electroporation (EP) in Combination With Cemiplimab (REGN2810) in Newly-Diagnosed Glioblastoma (GBM)

NCT03581292Phase 2Active Not Recruiting

Veliparib, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed Malignant Glioma Without H3 K27M or BRAFV600 Mutations

NCT06176066Phase 1RecruitingPrimary

PH Sensitive MRI Based Resections of Glioblastoma

NCT03919071Phase 2Active Not Recruiting

Dabrafenib Combined With Trametinib After Radiation Therapy in Treating Patients With Newly-Diagnosed High-Grade Glioma

NCT03797326Phase 2Completed

Efficacy and Safety of Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) in Previously Treated Participants With Select Solid Tumors (MK-7902-005/E7080-G000-224/LEAP-005)

NCT07464925Phase 1Recruiting

A Phase 1 Safety and Dose Finding Study of GLIX1 in Adults With Recurrent or Progressive High-grade Glioma

NCT06556563Phase 3RecruitingPrimary

EF-41/KEYNOTE D58: Phase 3 Study of Optune Concomitant With Temozolomide Plus Pembrolizumab in Newly Diagnosed Glioblastoma

NCT07560865Phase 1Recruiting

First-in Cancer-Type Phase I Study of FT536 for Recurrent WHO Grade 4 Astrocytoma

NCT07365124Not Yet Recruiting

MRinRT: Swansea University and SWWCC Collaboration Study.

NCT07195591Phase 3RecruitingPrimary

Beginning Radiation Immediately With GammaTile at GBM Excision Versus Standard of Care

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