Key Insights

Highlights

Success Rate

82% trial completion

Published Results

26 trials with published results (24%)

Clinical Risk Assessment

Based on trial outcomes

Moderate Risk

Score: 49/100

Termination Rate

8.3%

9 terminated out of 108 trials

Success Rate

82.0%

-4.5% vs benchmark

Late-Stage Pipeline

6%

7 trials in Phase 3/4

Results Transparency

63%

26 of 41 completed with results

Key Signals

26 with results82% success

Data Visualizations

Phase Distribution

94Total
Not Applicable (7)
Early P 1 (3)
P 1 (47)
P 2 (30)
P 3 (5)
P 4 (2)

Trial Status

Completed41
Recruiting17
Active Not Recruiting13
Not Yet Recruiting11
Unknown10
Terminated9

Trial Success Rate

82.0%

Benchmark: 86.5%

Based on 41 completed trials

Clinical Trials (108)

Showing 20 of 20 trials
NCT06804655Phase 2Not Yet Recruiting

Pharmacoscopy for Patients With Refractory Primary Brain Tumors

NCT02724579Phase 2Active Not RecruitingPrimary

Reduced Craniospinal Radiation Therapy and Chemotherapy in Treating Younger Patients With Newly Diagnosed WNT-Driven Medulloblastoma

NCT05835687Phase 1Recruiting

Loc3CAR: Locoregional Delivery of B7-H3-CAR T Cells for Pediatric Patients With Primary CNS Tumors

NCT04696029Phase 2RecruitingPrimary

DFMO as Maintenance Therapy for Molecular High/Very High Risk and Relapsed Medulloblastoma

NCT05128903Phase 2Active Not Recruiting

Quantitative Assessment of Radiation-induced Neuroinflammation - A Proof of Principle Study

NCT01445288Completed

Exploratory Study of Effects of Radiation Therapy in Pediatric Patients With Central Nervous System Tumors

NCT07085325RecruitingPrimary

CSIMEMPHIS: Long-term Follow-up of Medulloblastoma Survivors That Received Craniospinal Irradiation

NCT00840047Phase 2Active Not Recruiting

Methionine PET/CT Studies In Patients With Cancer

NCT05934630Terminated

Testing Cerebrospinal Fluid for Cell-free Tumor DNA in Children, Adolescents, and Young Adults With Brain Tumors

NCT05057702Not ApplicableRecruitingPrimary

Individualized Treatment Plan in Children and Young Adults With Relapsed Medulloblastoma and Ependymoma

NCT06607692Phase 1Recruiting

Study in Children and Adolescents of 177Lu-DOTATATE (Lutathera®) Combined With the PARP Inhibitor Olaparib for the Treatment of Recurrent or Relapsed Solid Tumours Expressing Somatostatin Receptor (SSTR) (LuPARPed).

NCT05278208Phase 1Recruiting

Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors

NCT07516353Not ApplicableNot Yet Recruiting

my.naviGATE: A Guide to After-Treatment Effects for Adolescents and Young Adults

NCT03251989Completed

Rare CNS Tumors Outcomes &Risk

NCT06161519Phase 1Recruiting

PLX038 in Primary Central Nervous System Tumors Containing MYC or MYCN Amplifications

NCT06639607Phase 1Not Yet Recruiting

PEP-CMV + Nivolumab for Newly Diagnosed Diffuse Midline Glioma/High-grade Glioma and Recurrent Diffuse Midline Glioma/High-grade Glioma, Medulloblastoma, and Ependymoma

NCT04978727Phase 1Active Not RecruitingPrimary

A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma

NCT04661384Phase 1Active Not Recruiting

Brain Tumor-Specific Immune Cells (IL13Ralpha2-CAR T Cells) for the Treatment of Leptomeningeal Glioblastoma, Ependymoma, or Medulloblastoma

NCT06701812Phase 2RecruitingPrimary

Digoxin Medulloblastoma Study

NCT03581240Unknown

An Intermediate Expanded Use Trial of DFMO

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