Key Insights

Highlights

Success Rate

83% trial completion

Published Results

26 trials with published results (23%)

Clinical Risk Assessment

Based on trial outcomes

Moderate Risk

Score: 49/100

Termination Rate

8.0%

9 terminated out of 113 trials

Success Rate

82.7%

-3.9% vs benchmark

Late-Stage Pipeline

6%

7 trials in Phase 3/4

Results Transparency

60%

26 of 43 completed with results

Key Signals

26 with results83% success

Data Visualizations

Phase Distribution

96Total
Not Applicable (8)
Early P 1 (3)
P 1 (48)
P 2 (30)
P 3 (5)
P 4 (2)

Trial Status

Completed43
Recruiting17
Active Not Recruiting14
Not Yet Recruiting12
Unknown10
Terminated9

Trial Success Rate

82.7%

Benchmark: 86.5%

Based on 43 completed trials

Clinical Trials (113)

Showing 20 of 20 trials
NCT01445288Completed

Exploratory Study of Effects of Radiation Therapy in Pediatric Patients With Central Nervous System Tumors

NCT03251989Completed

Rare CNS Tumors Outcomes &Risk

NCT06822842Completed

Accurate Diagnosis and Grading of Pediatric Solid Tumors Based on Pathological Large Models

NCT06624371Phase 1Recruiting

Atovaquone Combined With Radiation in Children With Malignant Brain Tumors

NCT04337177Phase 1Active Not Recruiting

Flavored, Oral Irinotecan VAL-413 (Orotecan®) Given With Temozolomide for Treatment of Recurrent Pediatric Solid Tumors

NCT06161519Phase 1Recruiting

PLX038 in Primary Central Nervous System Tumors Containing MYC or MYCN Amplifications

NCT07703605Not Yet Recruiting

AI-Assisted MRI Molecular Subtyping in Pediatric Brain Tumors

NCT06639607Phase 1Suspended

PEP-CMV + Nivolumab for Newly Diagnosed Diffuse Midline Glioma/High-grade Glioma and Recurrent Diffuse Midline Glioma/High-grade Glioma, Medulloblastoma, and Ependymoma

NCT05278208Phase 1Recruiting

Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors

NCT02724579Phase 2Active Not RecruitingPrimary

Reduced Craniospinal Radiation Therapy and Chemotherapy in Treating Younger Patients With Newly Diagnosed WNT-Driven Medulloblastoma

NCT07694622Not ApplicableNot Yet RecruitingPrimary

Targeting MYC in High-Risk Medulloblastoma

NCT06701812Phase 2RecruitingPrimary

Digoxin Medulloblastoma Study

NCT07085325RecruitingPrimary

CSIMEMPHIS: Long-term Follow-up of Medulloblastoma Survivors That Received Craniospinal Irradiation

NCT05835687Phase 1Active Not Recruiting

Loc3CAR: Locoregional Delivery of B7-H3-CAR T Cells for Pediatric Patients With Primary CNS Tumors

NCT03389802Phase 1Active Not Recruiting

Phase I Study of APX005M in Pediatric Central Nervous System Tumors

NCT07660458RecruitingPrimary

Parental Distress and Treatment Adherence in Pediatric Recurrent Medulloblastoma

NCT00840047Phase 2Active Not Recruiting

Methionine PET/CT Studies In Patients With Cancer

NCT00085735Phase 3CompletedPrimary

Comparison of Radiation Therapy Regimens in Combination With Chemotherapy in Treating Young Patients With Newly Diagnosed Standard-Risk Medulloblastoma

NCT00392327Phase 3Completed

Chemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed, Previously Untreated, High-Risk Medulloblastoma/PNET

NCT06607692Phase 1Recruiting

Study in Children and Adolescents of 177Lu-DOTATATE (Lutathera®) Combined With the PARP Inhibitor Olaparib for the Treatment of Recurrent or Relapsed Solid Tumours Expressing Somatostatin Receptor (SSTR) (LuPARPed).

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