Muscle Stretching - the Potential Role of Endogenous Pain Inhibitory Modulation on Stretch Tolerance

NCT03713788 | Completed DMC

• 1 other identifier: UniversityCND
• Study Type: interventional
• Target: 34
• Locations: 1 country
• Sites: 1

Brief Summary

This study investigates the influence of a remote, painful stimulus on stretch tolerance. Half of the participants will receive a conditioning painful stimulus following static stretching while the other half will rest quietly.

Conditions

Muscle Stretching Exercises; Pain Threshold

Keywords

Stretch tolerance; Range of Motion

Outcome Measures

Primary Outcomes (3)

• Knee extension range of motion

  Passively induced knee extension range of motion was measured usind the Biodex system 4 pro isokinetic dynomometer

  Passive knee extension range of motion was measured at baseline

• Change in knee extension range of motion between baseline and post stretch.

  Changes in passively induced knee extension range of motion was measured using the Biodex system 4 pro isokinetic dynomometer

  Changes in passive knee extension range of motion were measured 5 minutes after baseline measures following stretching

• Changes in knee extension range of motion between post stretch and post pain.

  Changes in passively induced knee extension range of motion was measured using the Biodex system 4 pro isokinetic dynomometer

  Changes in passive knee extension range of motion were measured 5 minutes after post stretch measures following intervention.

Secondary Outcomes (6)

• Surface electromyography measures of muscle activity

  Muscle activity during the passive knee extension motion was measured at baseline

• Changes in surface electromyography measures of muscle activity between baseline and post stretch measures.

  Changes in muscle activity during the passive knee extension motion were measured 5 minutes after baseline measures following stretching.

• Changes in surface electromyography measures of muscle activity between post stretch and post pain measures.

  Changes in muscle activity during the passive knee extension motion were measured 5 minutes after post stretch measures following intervention.

• Passive resistive torque using the Biodes system 4 pro.

  Passive resistive torque during the passive knee extension motion was measured at baseline.

• Changes in passive resistive torque measured using the Biodex system 4 pro between baseline and post stretch measures.

  Changes in passive resistive torque during the passive knee extension motion was measured 5 minutes after baseline measures following stretching.

Study Arms (2)

Experimental pain group

EXPERIMENTAL

subjects in the pain group were instructed to immerse their non-dominant hand into a container with circulating water at 1˚C to 4˚C and keep it there for 2 minutes. They were instructed to immerse it to wrist-level and keep the hand open.

Other: Cold pressor test

Control group

NO INTERVENTION

Participants rested in a seated position for 5 minutes.

Interventions

Cold pressor test OTHER

Participants placed their non-dominant hand into cold water for 2 minutes

Experimental pain group

Eligibility Criteria

• Age: 18 Years - 45 Years
• Gender Eligibility Details: Only males were included to avoid the potential effect that fluctuations in gonadal hormone values may have on the endogenous pain inhibitory mechanisms.
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Eligibility for participation included the absence of any pain or other conditions that might affect the somatosensory system.

You may not qualify if:

• Substance abuse,
• History of neurological or mental disabilities
• Lack of ability to comply with instructions
• Delayed onset of muscle soreness.

Sponsors & Collaborators

• University College of Northern Denmark: lead
• Aalborg University: collaborator

Study Sites (1)

University College of Northern Denmark

Aalborg, 9220, Denmark

Location

Study Officials

• Dorte Drachman, Msc.

  University College of Northern Denmark, Department of Physiotherapy

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Senior associate lecturer

Model Details: A sample of convenience was recruited for this cross-sectional study. Participants were randomly assigned to a pain group or a control group using counterbalanced block randomization. Passive knee extension range of motion was measured three consecutive times with five-minute intervals between measurements. Both groups underwent a static stretch protocol consisting of two bouts of thirty-second constant-angle static stretching of the knee flexors with a one-minute rest between bouts. Subjects were instructed to keep the limb relaxed as the lower leg was passively moved towards extension. Following stretching, the post-stretch measurement was performed. Finally, subjects in the pain group were instructed to immerse their non-dominant hand into a container with circulating water at 1˚C to 4˚C and keep it there for 2 minutes. A Biodex system 4 pro dynamometer was used to quantify range of motion and passive resistive torque. Muscle activity was recorded as surface electromyography.

Study Record Dates

• First Submitted: October 15, 2018
• First Posted: October 22, 2018
• Study Start: May 1, 2016
• Primary Completion: November 30, 2016
• Study Completion: November 30, 2016
• Last Updated: October 22, 2018

Record last verified: 2018-10

Data Sharing

• IPD Sharing: Will not share

Locations

DK (1)