Endogenous Modulation of Pain and Stretch Tolerance

NCT03886883 | Completed

• 1 other identifier: UniversityCND1
• Study Type: interventional
• Target: 19
• Locations: 1 country
• Sites: 1

Brief Summary

This study investigates the role of two endogenous inhibitory mechanisms; exercise-induced hypoalgesia (EIH) and a conditioning painful stimulus (CPM) on passive joint range of motion, passive resistive torque and pain sensitivity. The study is a randomized, repeated-measures cross-over study.

Conditions

Pain Threshold

Keywords

Stretch tolerance; Stretching Exercises; Exercise induced hypoalgesia

Outcome Measures

Primary Outcomes (3)

• Knee extension range of motion

  Passively induced knee extension range of motion was measured using the Biodex system 4 pro isokinetic dynamometer

  Passive knee extension range of motion was measured as a baseline just prior to the induction of exercise-induced hypoalgesia (EIH), Static stretch (SS), Rest and a conditioning painful stimulus (CPM)

• Knee extension range of motion

  Passively induced knee extension range of motion was measured using the Biodex system 4 pro isokinetic dynamometer

  Passive knee extension range of motion was measured 30 seconds after the induction of EIH, SS, Rest and CPM

• Knee extension range of motion

  Passively induced knee extension range of motion was measured using the Biodex system 4 pro isokinetic dynamometer

  Passive knee extension range of motion was measured 10 minutes after the induction of EIH, SS, Rest and CPM

Secondary Outcomes (6)

• Passive resistive torque

  Passive resistive torque was measured as a baseline just prior to the induction of EIH, SS, Rest and CPM

• Passive resistive torque

  Passive resistive torque was measured 30 seconds after the induction of EIH, SS, Rest and CPM

• Passive resistive torque

  Passive resistive torque was measured 10 minutes after the induction of EIH, SS, Rest and CPM

• Pressure pain thresholds

  Pressure pain thresholds were measured as a baseline just prior to the induction of EIH, SS, Rest and CPM

• Pressure pain thresholds

  Pressure pain thresholds were measured 30 seconds after the induction of EIH, SS, Rest and CPM

Study Arms (4)

Exercise-induced hypoalgesia (EIH)

EXPERIMENTAL

Exercise-induced hypoalgesia - isometric muscle contractions of the hand flexors

Other: Exercise induced hypoalgesia (EIH)

Static stretch (SS)

ACTIVE COMPARATOR

A static stretch of the knee flexors

Other: Static stretch (SS)

Rest

SHAM COMPARATOR

No intervention

Other: Rest

Conditioning painful stimulus (CPM)

EXPERIMENTAL

Conditioned pain modulation - cold pressure test

Other: Conditioned pain modulation (CPM)

Interventions

Exercise induced hypoalgesia (EIH) OTHER

An EIH response was induced by a 3-minute isometric contraction of the hand flexor muscles at 25% of maximal voluntary contraction (MVC).

Exercise-induced hypoalgesia (EIH)

Static stretch (SS) OTHER

Two bouts of 30 seconds of static stretching (SS) of the knee flexors.

Static stretch (SS)

Rest OTHER

The participants rested in a seated position for 10 minutes

Rest

Conditioned pain modulation (CPM) OTHER

A CPM response was induced by way of the cold pressor test.

Conditioning painful stimulus (CPM)

Eligibility Criteria

• Age: 18 Years - 45 Years
• Gender Eligibility Details: Only males were included to avoid the potential effect that fluctuations in gonadal hormone values may have on the endogenous pain inhibitory mechanisms.
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Eligibility for participation included the absence of any pain or other conditions that might affect the somatosensory system.

You may not qualify if:

• Substance abuse, History of neurological or mental disabilities, Lack of ability to comply with instructions, Delayed onset of muscle soreness.

Sponsors & Collaborators

• University College of Northern Denmark: lead

Study Sites (1)

University College of Northern Denmark

Aalborg, 9220, Denmark

Location

Related Publications (1)

• Stove MP, Hirata RP, Palsson TS. The tolerance to stretch is linked with endogenous modulation of pain. Scand J Pain. 2021 Jan 11;21(2):355-363. doi: 10.1515/sjpain-2020-0010. Print 2021 Apr 27.

  PMID: 34387949 DERIVED

MeSH Terms

Interventions

RE1-silencing transcription factor

Study Officials

• Dorte Drachman, Msc.

  University College of Northern Denmark, Department of Physiotherapy

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: Participants were blinded to the results of all measurements and naïve to research hypotheses.
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: This was a randomized, repeated-measures cross-over study. Passive knee extension range of motion was measured three consecutive times with five-minute intervals between measurements. Both groups underwent a static stretch protocol consisting of two bouts of thirty-second constant-angle static stretching of the knee flexors with a one-minute rest between bouts. Subjects were instructed to keep the limb relaxed as the lower leg was passively moved towards extension. Following stretching, the post-stretch measurement was performed. Finally, subjects in the pain group were instructed to immerse their non-dominant hand into a container with circulating water at 1˚C to 4˚C and keep it there for 2 minutes. A Biodex system 4 pro dynamometer was used to quantify range of motion and passive resistive torque. Pressure pain thresholds was assessed using a handheld pressure algometer (Somedic AB, Hörby, Sweden).

Study Record Dates

• First Submitted: March 13, 2019
• First Posted: March 22, 2019
• Study Start: October 1, 2017
• Primary Completion: December 30, 2017
• Study Completion: December 30, 2017
• Last Updated: March 26, 2019

Record last verified: 2019-03

Data Sharing

• IPD Sharing: Will not share

Locations

DK (1)