NCT03708952

Brief Summary

The association between lifestyle and dietary patterns with precursor lesions of colorectal cancer and cardiometabolic diseases is still unclear. This study is conducted in Jinhua, a city with a high prevalence of colorectal cancer in China, to assess the relationship between lifestyle and dietary factors with precursor lesions of colorectal cancer and cardiometabolic diseases.

Trial Health

75
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
25,000

participants targeted

Target at P75+ for all trials

Timeline
24mo left

Started May 2018

Longer than P75 for all trials

Geographic Reach
1 country

2 active sites

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress80%
May 2018May 2028

Study Start

First participant enrolled

May 1, 2018

Completed
6 months until next milestone

First Submitted

Initial submission to the registry

October 14, 2018

Completed
3 days until next milestone

First Posted

Study publicly available on registry

October 17, 2018

Completed
6.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2024

Completed
3.4 years until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2028

Expected
Last Updated

January 10, 2024

Status Verified

January 1, 2024

Enrollment Period

6.6 years

First QC Date

October 14, 2018

Last Update Submit

January 7, 2024

Conditions

PolypsCardiovascular Diseases

Keywords

Dietary factorsPrecursor lesions of colorectal cancerLifestylePolypsCardiovascular Diseases

Outcome Measures

Primary Outcomes (1)

  • Numbers of participants with polyps

    All polyps

    From entry into the study (baseline:2018-2022) until 2028

Secondary Outcomes (2)

  • Numbers of participants with different subtypes of polyps

    From entry into the study (baseline:2018-2022) until 2028

  • Numbers of participants with cardiometabolic diseases

    From entry into the study (baseline:2018-2022) until 2028

Other Outcomes (1)

  • Numbers of participants died

    From entry into the study (baseline:2018-2022) until 2028

Eligibility Criteria

Age45 Years - 74 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Subjects are eligible residents from 16 towns and villages of Jinhua, China.

You may qualify if:

  • Subject aged ≥45 and ≤74 years old
  • Subject has complete data on diet and follow-up time

You may not qualify if:

  • Colorectal cancer
  • Severe intestines problems

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

Lanxi Hospital of Traditional Chinese Medicine

Jinhua, Zhejiang, 321000, China

Location

Lanxi Red Cross Hospital

Lanxi, Zhejiang, 321100, China

Location

Biospecimen

Retention: SAMPLES WITH DNA

The investigators collect blood samples.

MeSH Terms

Conditions

PolypsCardiovascular Diseases

Condition Hierarchy (Ancestors)

Pathological Conditions, AnatomicalPathological Conditions, Signs and Symptoms

Study Officials

  • Weifang Zheng, MD

    Lanxi Red Cross Hospital

    PRINCIPAL INVESTIGATOR

  • Jingjing Jiao

    Zhejiang University

    PRINCIPAL INVESTIGATOR

  • Pan Zhuang

    Zhejiang University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor

Study Record Dates

First Submitted

October 14, 2018

First Posted

October 17, 2018

Study Start

May 1, 2018

Primary Completion

December 1, 2024

Study Completion (Estimated)

May 1, 2028

Last Updated

January 10, 2024

Record last verified: 2024-01

Locations

CN(2)