Effect of Short-term Chinese Tea-flavor Liquor Consumption

NCT01294995 | Completed Phase 1 DMC

• 1 other identifier: ST Chinese liquor study
• Study Type: interventional
• Target: 45
• Locations: 1 country
• Sites: 1

Brief Summary

Human studies of Chinese liquor are sparse. The investigators hypothesize that short-term Chinese Tea-flavor liquor (TFL) consumption may be beneficial to inflammation biomarkers and CVD risk factors. Guizhou Meijiao Liquor (GML) is a traditional Chinese liquor, fermented from sorghum, corn, sticky rice, wheat and rice, while TFL is a novel Chinese liquor fermented from above 5 grains plus green tea. Forty-five volunteers(23 males, 22 females) were selected to participate a paralleled randomized trial drinking 30 mL two kinds of Chinese liquors: TFL and GML respectively with meal every day for 28 days. Serums of volunteers were collected for analyzing serum lipids, inflammation biomarkers and CVD risk factors. TFL could significantly decrease systolic blood pressure of males, but increase diastolic blood pressure of females. TFL could also decreased blood lipid of volunteers, especially for females. Both liquor significantly decrease serum uric acid and glucose in males and females. The effect of the two liquors on inflammation biomarkers were complicated and needs further research work. TFL may possess more beneficial effect on CVD risk factors than GML probably because of the special fermentation products of green tea with other grains.

Conditions

Cardiovascular Diseases

Keywords

short term consumption; Chinese liquor; serum lipids; uric acid; inflammation biomarkers

Study Arms (2)

Tea-flavor Liquor, taken with meal

EXPERIMENTAL

including 12 males and 11 females

Dietary Supplement: Tea-flavor Liquor

Guizhou Meijiao Liquor, taken with meal

PLACEBO COMPARATOR

including 11 males and 11 females

Dietary Supplement: Guizhou Meijiao Liquor

Interventions

Tea-flavor Liquor DIETARY_SUPPLEMENT

30 mL of Tea-flavor Liquor(45% alcohol content)

Tea-flavor Liquor, taken with meal

Guizhou Meijiao Liquor DIETARY_SUPPLEMENT

30 mL of Guizhou Meijiao Liquor (45% alcohol content)

Guizhou Meijiao Liquor, taken with meal

Eligibility Criteria

• Age: 23 Years - 28 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy male and female volunteers

You may not qualify if:

• Subjects with a history of liver disease, diabetes, or heart disease
• Smokers

Sponsors & Collaborators

• Zhejiang University: lead
• Guizhou Meijiao Co., Ltd: collaborator

Study Sites (1)

Department of food science and nutrition

Hangzhou, Zhejiang, 310029, China

Location

MeSH Terms

Conditions

Cardiovascular Diseases

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: February 11, 2011
• First Posted: February 14, 2011
• Study Start: October 1, 2010
• Primary Completion: November 1, 2010
• Study Completion: November 1, 2010
• Last Updated: February 14, 2011

Record last verified: 2010-10

Locations

CN (1)