Beta-alanine Supplementation and High-intensity Interval Training

NCT03708185 | Completed

• 1 other identifier: 180509/B/02
• Study Type: interventional
• Target: 26
• Locations: 1 country
• Sites: 1

Brief Summary

The present study will seek to quantify whether a period of HIIT alongside β-alanine supplementation will improve the adaptation to training, and therefore performance, more than a period of HIIT alone.

Conditions

Healthy

Outcome Measures

Primary Outcomes (1)

• Change from baseline work done on a cycle ergometer in a cycling capacity test at 110%VO2max following a period of 4 weeks of beta-alanine supplementation and then 8 weeks of beta-alanine supplementation and high intensity interval training

  Subjects will have previously performed an incremental test to exhaustion (VO2max test). A work-load that corresponds to 110 % of the peak power output (Wmax) will be calculated, and participants will be asked to cycle at this power output until volitional exhaustion. This test will be preceded but a bout of 90-minute cycling at 65%VO2max. Tests will be performed on a Lode Excalibur Sport, and software linked to the bike will record data.

  At weeks 0, 4 and 12 of study.

Secondary Outcomes (9)

• VO2max

  At weeks 0, 4, 8 and 12 of study.

• Substrate utilisation

  At weeks 0, 4 and 12 of study.

• Muscle carnosine concentration

  At weeks 0, 4 and 12 of study.

• Muscle enzyme (citrate synthase, hexokinase, β-HAD, PFK) activity

  At weeks 0, 4 and 12 of study.

• Muscle buffering capacity

  At weeks 0, 4 and 12 of study.

Study Arms (2)

HIIT + beta-alanine

EXPERIMENTAL

Participants will ingest an active supplement containing beta-alanine for a period of 12 weeks. During the last 8 weeks of that period, participants will take part in a structured program of high-intensity interval training.

Dietary Supplement: Beta-alanine

HIIT + placebo

EXPERIMENTAL

Participants will ingest a placebo supplement containing no beta-alanine for a period of 12 weeks. During the last 8 weeks of that period, participants will take part in a structured program of high-intensity interval training.

Dietary Supplement: Placebo

Interventions

Beta-alanine DIETARY_SUPPLEMENT

N/A: see arm description

HIIT + beta-alanine

Placebo DIETARY_SUPPLEMENT

N/A: see arm description

HIIT + placebo

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Moderately trained (vo2max: 50 - 60 ml/kg/min).
• Females must be taking an oral contraceptive, or using a contraceptive implant.

You may not qualify if:

• A recent history of musculoskeletal injury
• Diagnosed cardiovascular or metabolic disease
• Regular use of beta-alanine supplements

Sponsors & Collaborators

• University of Exeter: lead

Study Sites (1)

School of Sport and Health Sciences

Exeter, Devon, EX4 4JA, United Kingdom

Location

MeSH Terms

Interventions

beta-Alanine

Intervention Hierarchy (Ancestors)

Alanine; Amino Acids; Amino Acids, Peptides, and Proteins

Study Officials

• Andrew D Davenport, MSc

  The University of Exeter

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Masking Details: Doubly-blinded \& randomised using an online randomisation website.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 12, 2018
• First Posted: October 17, 2018
• Study Start: June 4, 2018
• Primary Completion: December 20, 2019
• Study Completion: June 28, 2021
• Last Updated: September 30, 2021

Record last verified: 2021-09

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)