Hydration and Exercise Performance in Cycling

NCT03304197 | Completed

• 1 other identifier: 170614/A/01
• Study Type: interventional
• Target: 15
• Locations: 1 country
• Sites: 1

Brief Summary

This study will evaluate the effects manipulating ingested fluids can have on hydration status and cycling performance. There will be 4 different conditions.

Conditions

Healthy

Outcome Measures

Primary Outcomes (1)

• Absorption of fluid through the gut

  Absorption of drinks through the gut will be measured using 2 boluses of deuterated water. This will be consumed alongside 2 of the drinks, and blood samples will be used to quantify enrichment. Total body water calculations are required to provide corrections in equations related to D2O. H218O will be consumed in order to quantify total body water: this will be provided in a single bolus before each trial.

  To begin 10 minutes after the completion of the 90 minute steady-state cycle

Secondary Outcomes (1)

• Work done (kJ) during 15 minute cycling time-trial

  Throughout the 90 minute steady-state cycle & the 15 minute time trial.

Other Outcomes (5)

• Substrate utilisation

  Throughout the 90 minute steady-state cycle

• Plasma metabolites

  Throughout the 90 minute steady-state cycle and time-trial

• Heart rate

  Throughout the 90 minute steady-state cycle and time-trial

Study Arms (4)

Dehydrated

EXPERIMENTAL

90 minutes cycling, without the ingestion of any fluids, followed by a 15 minute cycling time trial test

Other: Dehydrated

Hypotonic

EXPERIMENTAL

90 minutes cycling, with the ingestion of six 250 ml carbohydrate (6g sucrose, 3g glucose) drinks, followed by a 15 minute cycling time trial test

Dietary Supplement: Hypotonic

Isotonic

EXPERIMENTAL

90 minutes cycling, with the ingestion of six 250 ml carbohydrate (6g glucose, 3g fructose) drinks, followed by a 15 minute cycling time trial test

Dietary Supplement: Isotonic

Placebo

EXPERIMENTAL

90 minutes cycling, with the ingestion of six 250 ml taste-matched water drinks, followed by a 15 minute cycling time trial test

Dietary Supplement: Placebo

Interventions

Hypotonic DIETARY_SUPPLEMENT

N/A: see arm description

Hypotonic

Isotonic DIETARY_SUPPLEMENT

N/A: see arm description

Isotonic

Placebo DIETARY_SUPPLEMENT

N/A: see arm description

Placebo

Dehydrated OTHER

N/A: see arm description

Dehydrated

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Highly trained cyclists (vo2max \>55 ml/kg/min, PPO (peak power output) \> 4 w/kg)
• Training at least 4 times a week
• Females must be taking an oral contraceptive, or using the contraceptive implant

You may not qualify if:

• Recent history of musculoskeletal injury
• Diagnosed cardiovascular disease
• Regular use of nutritional supplements that may interfere with the protocol

Sponsors & Collaborators

• University of Exeter: lead

Study Sites (1)

School of Sports and Health Sciences

Exeter, Devon, EX1 2LU, United Kingdom

Location

Study Officials

• Andrew D Davenport, MSc

  The University of Exeter

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Masking Details: Doubly-blinded \& randomised using an online randomisation website.
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 13, 2017
• First Posted: October 6, 2017
• Study Start: September 11, 2017
• Primary Completion: June 1, 2018
• Study Completion: June 1, 2018
• Last Updated: October 12, 2018

Record last verified: 2018-10

Locations

GB (1)