Clinical Significance of Supranormal Differential Renal Function in the Recovery of Hydronephrosis

NCT01839006 | Completed DMC

• 2 other identifiers: supranormalsupranormal DRF
• Study Type: observational
• Target: 34
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to assess the clinical significance of supranormal differential renal function (DRF) in the recovery of unilateral hydronephrosis (HN) after surgery, pediatric patients who underwent pyeloplasty for ureteropelvic junction obstruction (UPJO) who showed supranormal DRF (\> 55%) in the DTPA renography will be analyzed.

Conditions

Hydronephrosis

Keywords

hydronephrosis; ultrasonography; Kidney Function Test; Patients with unilateral UPJO and patients with preop HN in USG and supranormal renal function in DTPA renography

Outcome Measures

Primary Outcomes (1)

• Hydronephrosis

  The grade of hydronephrosis would be check at 6 months postoperatively.

  postop 6 months

Secondary Outcomes (1)

• renal parenchymal thickness

  postop 6 months

Study Arms (1)

patients with supranormal renal function

Patients with preoperative HN and supranormal renal function in DTPA renography

Procedure: dismembered pyeloplasty

Interventions

dismembered pyeloplasty PROCEDURE

Using a flank approach, as the patient was placed in the lateral decubitus position, and an anterior subcostal incision was made. The narrow segment of UPJ was identified and resected, and then the proximal edge of the ureter was spatulated to allow a wide anastomosis between the ureter and the most dependent part of the renal pelvis. The extent of renal pelvis reduction was decided by the surgeon.

patients with supranormal renal function

Eligibility Criteria

• Age: Up to 18 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

patients with unilateral UPJO pediatric patients who underwent dismembered pyeloplasty and preoperative HN in USG and supranormal renal function in DTPA renography

You may qualify if:

• ureteropelvic junction obstruction
• hydronephrosis
• differential renal function more than 55% in DTPA
• follow-up period more than 1 year

You may not qualify if:

• urological anomalies, such as vesicoureteral reflux, ureterocele, cystic kidney disease, posterior urethral valves, duplex anomalies, neurogenic bladder, and solitary kidney or patients who underwent any previous urological surgery

Sponsors & Collaborators

• Seoul National University Hospital: lead

Study Sites (1)

Seoul National University Hospital

Seoul, South Korea

Location

MeSH Terms

Conditions

Hydronephrosis

Condition Hierarchy (Ancestors)

Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Study Officials

• Sung Yong Cho, M.D.

  Seoul National Universitiy Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Seoul National University Hospital

Study Record Dates

• First Submitted: June 25, 2011
• First Posted: April 24, 2013
• Study Start: June 1, 2011
• Primary Completion: June 1, 2011
• Study Completion: June 1, 2011
• Last Updated: April 24, 2013

Record last verified: 2013-04

Locations

KR (1)