Comparative Characteristics of Asthmatic Patients With and Without Nasal Polyposis: an Observational, Cross-sectional Study of the Quebec Heart and Lung Institute-Laval University Asthma Database.
Sponsor study identifier
observational
1,293
1 country
1
Study Start
July 19, 2018
Actual (reported)Primary Completion
September 15, 2018
Actual (reported)Study Completion
September 15, 2018
Actual (reported)Asthma is often associated with various comorbidities that may influence its clinical expression. Among those, chronic rhinosinusitis with nasal polyposis (CRSwNP) is observed in 5% of cases. Asthmatic patients with CRSwNP appear to have more severe and poorly controlled asthma, as well as greater bronchial and systemic inflammation, especially those using inhaled corticosteroids as control medication. However, this remains to be validated. In the last decade, there has been interest labeled for phenotyping of asthma and CRSwNP. However, there is scarce data on the phenotype of asthma with CRSwNP. This study aims to describe the phenotype of asthmatic patients with CRSwNP according to the clinical, physiological and inflammatory characteristics and whether there is a more severe phenotype related to the dose of inhaled corticosteroids and the percentage of induced sputum eosinophils.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
September 15, 2018
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
July 19, 2018
Actual (reported)September 15, 2018
Actual (reported)September 15, 2018
Actual (reported)October 2, 2018
Actual (reported)October 3, 2018
Actual (reported)Asthma severity
Prevalence of asthmatic with CRSwNP in mild, moderate and severe asthma
Baseline
Sputum inflammatory phenotype
Baseline
Asthmatic patients with a diagnosis of CRSwNP
Asthmatic patients without a diagnosis of CRSwNP
Asthmatic patients from the Quebec city region.
Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec
Québec, Quebec, G1V 4G5, Canada
Birs I, Boulay ME, Bertrand M, Cote A, Boulet LP. Heterogeneity of asthma with nasal polyposis phenotypes: A cluster analysis. Clin Exp Allergy. 2023 Jan;53(1):52-64. doi: 10.1111/cea.14247. Epub 2022 Nov 1.
Louis-Philippe Boulet, MD
IUCPQ-UL
1,293 participants (actual enrollment reported by the registry).
First Submitted
October 2, 2018
First Posted
October 3, 2018
Study Start
July 19, 2018
Actual (reported)Contact the study team to confirm eligibility.
Primary Completion
September 15, 2018
Actual (reported)Study Completion
September 15, 2018
Actual (reported)Last Updated
October 3, 2018
Record last verified: 2018-10
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Source: ClinicalTrials.gov.
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