Discovery of Novel Biomarkers of Dietary Exposure in the EPIC Calibration Study
Mining the Urinary and Serum Metabolome for Discovery of Novel Biomarkers of Dietary Exposure in the EPIC Calibration Study
1 other identifier
observational
494
0 countries
N/A
Brief Summary
This proposal aims at identifying new biomarkers of dietary exposure using metabolomic approaches. This project is based on the European Prospective Investigation on Cancer and Nutrition (EPIC) Calibration Study and more particularly upon a subset of 494 men and women from 4 European countries (Germany, Greece, Italy and France). Urine and blood samples are analyzed by untargeted metabolomics.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Apr 2012
Shorter than P25 for all trials
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 26, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 23, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
February 23, 2013
CompletedFirst Submitted
Initial submission to the registry
September 21, 2018
CompletedFirst Posted
Study publicly available on registry
September 25, 2018
CompletedOctober 10, 2018
October 1, 2018
10 months
September 21, 2018
October 8, 2018
Conditions
Outcome Measures
Primary Outcomes (1)
Metabolite concentrations in plasma and urine
Food-derived Metabolite concentrations in plasma and urine are measured by high resolution mass spectrometry coupled to ultrahigh performance chromatography.
1 day
Interventions
Observational study. No intervention.
Eligibility Criteria
494 men and women from 4 European countries (Germany, Greece, Italy and France) selected from the EPIC Calibration study. Different settings by centre; mostly general population with some exceptions: women of a health insurance company for teachers and school workers (France), women attending breast cancer screening (Florence-Italy), mainly blood donors (most centers in Italy) and a cohort consisting predominantly of vegetarians (the 'health-conscious' group in Oxford, UK).
You may qualify if:
- Aged 30-70
- Healthy
- Residing within Europe.
- Have donated one 24-hr urine sample, blood serum.
- Have filled one 24-hr dietary recall (24HDR) and food frequency questionnaire (FFQ).
You may not qualify if:
- hr urine sample and 24-hr dietary recall not collected on a same day.
- Incomplete collection of 24-hr urine sample.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- International Agency for Research on Cancerlead
- Imperial College Londoncollaborator
- Centre for Research in Epidemiology and Population Health (CESP)collaborator
- Gustave Roussy, Cancer Campus, Grand Pariscollaborator
- German Cancer Research Centercollaborator
- German Institute of Human Nutritioncollaborator
- Hellenic Health Foundationcollaborator
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milanocollaborator
- Cancer Prevention and Research Institute, Italycollaborator
- Federico II Universitycollaborator
- Center for Cancer Prevention (CPO)collaborator
- Azienda Sanitaria Provinciale Ragusacollaborator
Related Publications (3)
Riboli E, Hunt KJ, Slimani N, Ferrari P, Norat T, Fahey M, Charrondiere UR, Hemon B, Casagrande C, Vignat J, Overvad K, Tjonneland A, Clavel-Chapelon F, Thiebaut A, Wahrendorf J, Boeing H, Trichopoulos D, Trichopoulou A, Vineis P, Palli D, Bueno-De-Mesquita HB, Peeters PH, Lund E, Engeset D, Gonzalez CA, Barricarte A, Berglund G, Hallmans G, Day NE, Key TJ, Kaaks R, Saracci R. European Prospective Investigation into Cancer and Nutrition (EPIC): study populations and data collection. Public Health Nutr. 2002 Dec;5(6B):1113-24. doi: 10.1079/PHN2002394.
PMID: 12639222BACKGROUNDSlimani N, Ferrari P, Ocke M, Welch A, Boeing H, Liere M, Pala V, Amiano P, Lagiou A, Mattisson I, Stripp C, Engeset D, Charrondiere R, Buzzard M, Staveren W, Riboli E. Standardization of the 24-hour diet recall calibration method used in the european prospective investigation into cancer and nutrition (EPIC): general concepts and preliminary results. Eur J Clin Nutr. 2000 Dec;54(12):900-17. doi: 10.1038/sj.ejcn.1601107.
PMID: 11114689BACKGROUNDEdmands WM, Ferrari P, Rothwell JA, Rinaldi S, Slimani N, Barupal DK, Biessy C, Jenab M, Clavel-Chapelon F, Fagherazzi G, Boutron-Ruault MC, Katzke VA, Kuhn T, Boeing H, Trichopoulou A, Lagiou P, Trichopoulos D, Palli D, Grioni S, Tumino R, Vineis P, Mattiello A, Romieu I, Scalbert A. Polyphenol metabolome in human urine and its association with intake of polyphenol-rich foods across European countries. Am J Clin Nutr. 2015 Oct;102(4):905-13. doi: 10.3945/ajcn.114.101881. Epub 2015 Aug 12.
PMID: 26269369RESULT
Related Links
Biospecimen
24-hour urine samples Plasma samples
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
September 21, 2018
First Posted
September 25, 2018
Study Start
April 26, 2012
Primary Completion
February 23, 2013
Study Completion
February 23, 2013
Last Updated
October 10, 2018
Record last verified: 2018-10