Creatine Timing and Resistance Training Adaptations.

NCT03678857 | Completed

• 1 other identifier: 22261
• Study Type: interventional
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

Emerging evidence suggests that the timing of creatine supplementation may be an important regulator of muscle growth and strength. It is unclear whether creatine ingested before or after resistance training is more beneficial. A limitation of previous research is the use of a between subject design. A between subject design is associated with several potential confounders (habitual diet, genetics, activities of daily living, etc.) that may have masked the true effect. The purpose of this study is to examine the effect of creatine timing (creatine before vs. creatine after) using a randomized, double blind, repeated measures, within-subject design. Participants will resistance train their left arm and left leg one day and their right arm and right leg the next day. Participants will supplement with creatine BEFORE one of the training days (randomized to either left or right side) and on the opposite training day (opposite side of the body to the previous training day) supplement with creatine AFTER training. Having the same person in both conditions will control for genetics, habitual diet, other daily activities, and so on, that may have confounded previous research. Muscle mass and strength changes will be measured in each limb prior to and following 8 weeks of training to determine whether creatine timing influenced muscle growth. Research Question: To determine whether creatine supplementation timing (i.e., before versus after training) effects 8 weeks of resistance training adaptations (i.e., muscle growth and strength changes).

Conditions

Healthy

Keywords

creatine, hypertrophy, strength

Outcome Measures

Primary Outcomes (2)

• Hypertrophy (Muscle thickness will be determined via ultrasound)

  Muscle thickness will be determined via ultrasound.

  8 weeks

• Strength (1 repetition maximum will be determined via standard 1RM protocols)

  1 repetition maximum will be determined via standard 1RM protocols

  8 weeks

Study Arms (2)

Creatine Before

EXPERIMENTAL

Receives Creatine before and placebo after training.

Dietary Supplement: Creatine

Creatine After

EXPERIMENTAL

Receives creatine after and placebo before training.

Dietary Supplement: Creatine

Interventions

Creatine DIETARY_SUPPLEMENT

Participants will resistance train their left arm and left leg one day and their right arm and right leg the next day. Participants will supplement with creatine BEFORE one of the training days (randomized to either left or right side) and on the opposite training day (opposite side of the body to the previous training day) supplement with creatine AFTER training. Having the same person in both conditions will control for genetics, habitual diet, other daily activities, and so on, that may have confounded previous research. Muscle mass and strength changes will be measured in each limb prior to and following 8 weeks of training to determine whether creatine timing influenced muscle growth. Research Question: To determine whether creatine supplementation timing (i.e., before versus after training) effects 8 weeks of resistance training adaptations (i.e., muscle growth and strength changes).

Creatine After; Creatine Before

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• You may be able to participate in this study if you are between the ages of 18 and 35, are free of disease (e.g., diabetes), do not currently take creatine or other supplements (within the last 12 weeks), and have no known cardiovascular disease or other medical conditions which prevent you from performing physical activity or this type of nutritional supplement.
• You must also have no other reasons that might make exercise unsafe for you. You will complete a questionnaire (Get Active Questionnaire) to help identify any illness or health concern that could be worsened by performing exercise or make exercise unsafe for you.

You may not qualify if:

• You will not be eligible to participate in this study:
• If your doctor has informed you that you have a heart condition and should only do physical activity recommended by a doctor.
• If you feel pain in your chest when you perform any physical activity.
• If in the past the month you have had chest pain when you were not doing any physical activity.
• If you lose your balance or consciousness because of dizziness.
• If you have bone or joint problem (for example, back, knee, or hip) that could be made worse by a change in your physical activity.
• You have previously had a heart attack or stroke
• If you know of any other reason why you should not do physical activity.
• You currently take creatine supplements and/or other "performance enhancing" nutritional supplements

Sponsors & Collaborators

• Brandon University: lead

Study Sites (1)

Brandon University

Brandon, Manitoba, R7A 6A9, Canada

Location

MeSH Terms

Conditions

Hypertrophy

Interventions

Creatine

Condition Hierarchy (Ancestors)

Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Guanidines; Amidines; Organic Chemicals; Amino Acids; Amino Acids, Peptides, and Proteins

Study Officials

• Scott C Forbes, PhD

  Brandon University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: An independent researcher will label the placebo and creatine and only reveal which group is which after data has been analyzed.
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 18, 2018
• First Posted: September 20, 2018
• Study Start: September 15, 2018
• Primary Completion: June 1, 2020
• Study Completion: June 1, 2020
• Last Updated: December 16, 2020

Record last verified: 2020-12

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)