Influence of Expectations on Change in Pain Perception After a 3 Min Wallsquat Exercise.

NCT03678662 | Completed

• 1 other identifier: 62039
• Study Type: interventional
• Target: 83
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to investigate how expectations induced by information given prior to exercise influence the magnitude of exercise-induced hypoalgesia after a 3 min wallsquat exercise in healthy subjects. The study is a double blinded (participant, investigator) randomized controlled trial The results from the study may be of great importance to the understanding of exercise-induced hypoalgesia, and whether the information related to exercise as pain relief can be used in practice for patients with pain. The subjects are randomized to 1 in 3 groups. Hypoalgesia expectation, hyperalgesia expectation, neutral expectation. Each group (besides the neutral group) is given different information of what to expect on pain ratings after a 3 minutes wallsquat.

Conditions

Pain; Physical Activity

Keywords

Exercise-induced hypoalgesia, expectation, pain sensitivity

Outcome Measures

Primary Outcomes (2)

• Pressure pain threshold

  Between group comparison of the primary outcome, change in pressure pain threshold from baseline to post test. Pressure pain threshold is measured with a cuff algometer and pressure algometer respectively. Pressure pain threshold is measured in Kilopascal with rising pressure from 0 to infinity Kilopascal on the pressure algometer and from 0 to 100 Kilopascal on the cuff algometer. The cuff algometer is self-administered by the subject with a handheld joypad illustrating a Visual Analog Scala. Pressure pain threshold is registered in the computer when the subject reaches 0.1 centimeter and 1 centimeter on Visual Analog Scala on the joypad.

  At baseline before randomization and after the 3 minutes wallsquat - Day 1

• Pressure pain tolerance

  Between group comparison of the primary outcome, change in pressure pain tolerance from baseline to post test.. Pressure pain tolerance is measured with a cuff algometer. Pressure pain tolerance is measured in Kilopascal with rising pressure from 0 to 100 Kilopascal. The cuff algometer is self-administered by the subject with a handheld joypad illustrating a Visual Analog Scala. Pressure pain tolerance is registered in the computer when the subject reaches 10 centimeter on Visual Analog Scala on the joypad. If the 100 kilopascal on the cuff algometer is reached before the subjects maximum tolerance, the present score on Visual Analog Scala is assessed.

  At baseline before randomization and after the 3 minutes wallsquat - Day 1

Secondary Outcomes (3)

• Retrospective expectation for hypoalgesia and hyperalgesia after 3 minutes wall squat.

  Post-test score at day 1 (immediately after the last pain rating)

• Numeric Pain Rating Scale (NPRS)

  Test score at day 1 (during the 3 minute wall squat)

• International Physical Activity Questionaires (IPAQ)

  Pre test, baseline - day 1

Study Arms (3)

hyperalgesia expectation

EXPERIMENTAL

In this group the subjects will be told that the 3 minutes wall squat will have pain-enhancing effects.

Other: Neutral

hypoalgesia expectation

EXPERIMENTAL

In this group the subjects will be told that the 3 minutes wall squat will have pain-diminishing effects.

Other: Hypoalgesia expectation

Neutral

ACTIVE COMPARATOR

In this group the subjects expectations are not manipulated

Other: Hyperalgesia expectation

Interventions

Hypoalgesia expectation OTHER

"Before and after the squat exercise, assessment of how you experience pressure pain with the 2 devices you have just become acquainted with will be repeated. While doing the squat exercise you will be asked to indicate pain in the thigh muscles. What we currently know about the effect of exercise on the experience of pressure pain is that after eg. cycling or walking, more pressure can be applied before the pressure starts to hurt and more pressure is required before you can't withstand anymore. Whether this applies to a squat exercise, as the one you are about to perform, has not yet been investigated, but we expect that the same applies here, namely, that more pressure is required before you feel the pressure begins to hurt you and you will be able to endure a greater pressure." Supported by visual information.

Also known as: Randomization group a

hypoalgesia expectation

Hyperalgesia expectation OTHER

"Before and after the squat exercise, assessment of how you experience pressure pain with the 2 devices you have just become acquainted with will be repeated. While doing the squat exercise you will be asked to indicate pain in the thigh muscles. What we currently know is that exercise can cause muscle pain, both during and after training. You may have experienced muscle soreness yourself in relation to training? We expect that the same will apply here. Namely, after performing this squat exercise, which will likely hurt your thigh muscles while doing it, you will experience that the pressure applied afterwards, with the two devices you have just become acquainted with, should be less before it starts to hurt and that you can endure less pressure." Supported by visual information.

Also known as: Randomization group b

Neutral

Neutral OTHER

"Soon you are going to do a training exercise in a squat position up against the wall for 3 min. Following the squat exercise, we will repeat the measurement of how you experience pressure pain with the 2 devices you have just become acquainted with. While doing the squat exercise you will be asked to indicate pain in the thigh muscles."

Also known as: Randomization group c

hyperalgesia expectation

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy subjects without current recurrent or prolonged painful diseases.
• The subjects should speak and understand Danish.

You may not qualify if:

• Pregnancy
• Previous addictive behavior defined as abuse of hash, opioids or other euphoric substances.
• Previous painful or mental illnesses, neurological or circulatory diseases in the form of heart or lung disease.
• Lack of co-operation.
• Subjects who perform elite sports.

Sponsors & Collaborators

• Odense University Hospital: lead
• University of Southern Denmark: collaborator

Study Sites (1)

Pain Center South

Odense, Fyn, 5000, Denmark

Location

Related Publications (1)

• Vaegter HB, Thinggaard P, Madsen CH, Hasenbring M, Thorlund JB. Power of Words: Influence of Preexercise Information on Hypoalgesia after Exercise-Randomized Controlled Trial. Med Sci Sports Exerc. 2020 Nov;52(11):2373-2379. doi: 10.1249/MSS.0000000000002396.

  PMID: 32366799 DERIVED

MeSH Terms

Conditions

Pain; Motor Activity

Condition Hierarchy (Ancestors)

Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Behavior

Study Officials

• Gitte Handberg, MD

  Pain Center, OUH

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Masking Details: Participants will not be aware of which group they are allocated to. The experimenter who is assessing pressure pain threshold and tolerance is blinded to the study group of the participant.
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Stud. M.Sc. Physiotherapy

Study Record Dates

• First Submitted: September 12, 2018
• First Posted: September 19, 2018
• Study Start: September 19, 2018
• Primary Completion: November 22, 2018
• Study Completion: November 22, 2018
• Last Updated: November 26, 2018

Record last verified: 2018-11

Locations

DK (1)