Influence of Pain on Exercise-induced Hypoalgesia

NCT05299268 | Completed

• 1 other identifier: S-20210184
• Study Type: interventional
• Target: 34
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to investigate how acute pain induced by hypertonic saline prior to exercise influence the magnitude of exercise-induced hypoalgesia after 1x3 min seated isometric knee extension exercise in healthy women. The study is a blinded randomized cross-over trial The results from the study may be of great importance to the understanding of exercise-induced hypoalgesia, and whether the presence of pain affects the effects of exercise.

Conditions

Pain; Healthy

Outcome Measures

Primary Outcomes (1)

• Change in pressure pain threshold will be assessed over the dominant quadriceps muscle

  Between group comparison of the primary outcome, which is change in pressure pain threshold over the dominant quadriceps muscle before and after performing seated isometric knee extension. Pressure pain threshold is measured with a handheld pressure algometer.

  Baseline, Day 2 (within 1 week of baseline), Day 3 (within 1 week of Day 2)

Secondary Outcomes (2)

• Pressure pain threshold at the non-dominant quadriceps muscle and non-dominant trapezius muscle

  Baseline, Day 2 (within 1 week of baseline), Day 3 (within 1 week of Day 2)

• Pain Intensity in dominant thigh

  Assessed before and immediately after hypertonic and isotonic saline injection as well as 1, 2 and 3 minutes into the Seated Isometric Knee Extension, and immediately after the end of the seated isometric knee extension

Other Outcomes (4)

• Pressure pain threshold at the dominant and non-dominant thigh as well as non-dominant trapezius muscle

  Before and after determining maximal voluntary contraction on the fist test day and prior to saline injections

• Rating of perceived exertion (RPE)

  Assessed 1, 2 and 3 minutes into the Seated Isometric Knee Extension

• Quantifying the individual´s pain experience

  Baseline

Study Arms (2)

Pain (hypertonic saline)

EXPERIMENTAL

Injection (1 ml) of painful hypertonic saline (5.8%) prior to performance of the 1x3 min Seated Isometric Knee Extension

Behavioral: Pain (hypertonic saline)

No pain (isotonic saline)

PLACEBO COMPARATOR

Injection (1 ml) of non-painful isotonic saline (0.9%) prior to performance of the 1x3 min Seated Isometric Knee Extension

Behavioral: No pain (Isotonic saline)

Interventions

Pain (hypertonic saline) BEHAVIORAL

A bolus injection (1 ml) of hypertonic saline (5.8%) is injected into the dominant vastus medialis muscle 20 cm proximal from the basis of patella before performance of the 1x3 min Seated Isometric Knee Extension.

Pain (hypertonic saline)

No pain (Isotonic saline) BEHAVIORAL

A bolus injection (1 ml) of isotonic saline (0.9%) is injected into the dominant vastus medialis muscle 20 cm proximal from the basis of patella before performance of the 1x3 min Seated Isometric Knee Extension

No pain (isotonic saline)

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Pain-free
• Understands and writes Danish

You may not qualify if:

• Pregnancy
• Previous addictive behaviour defined as abuse of hash, opioids or other euphoric substances.
• Previous painful or mental illnesses, neurological or circulatory diseases in the form of heart or lung disease.
• Surgery in the lower extremities within the last 12 months
• Chronic or actual pain on the days of testing
• Under the influence on the days of testing
• Inability to cooperate

Sponsors & Collaborators

• Aalborg University: lead
• University of Southern Denmark: collaborator

Study Sites (1)

Dept. Of Health Science and Technology, Aalborg University

Aalborg, 9220, Denmark

Location

Related Publications (1)

• Mohrsen A, Lund H, Rasmussen SZ, Vaegter HB, Vela J, Hansen S, Christensen SWM. Acute exercise of painful muscles does not reduce the hypoalgesic response in young healthy women - a randomized crossover study. Scand J Pain. 2023 May 4;23(3):599-607. doi: 10.1515/sjpain-2022-0127. Print 2023 Jul 26.

  PMID: 37137551 DERIVED

MeSH Terms

Conditions

Pain

Interventions

Saline Solution, Hypertonic; Sodium Chloride

Condition Hierarchy (Ancestors)

Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Hypertonic Solutions; Solutions; Pharmaceutical Preparations; Chlorides; Hydrochloric Acid; Chlorine Compounds; Inorganic Chemicals; Sodium Compounds

Study Officials

• Steffan WM Christensen, PhD

  Aalborg University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Masking Details: Assessor and participants will be blinded to the order of injections.
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Model Details: This study is a 2-arm randomized controlled cross-over trial with 1-7 days between arms

Study Record Dates

• First Submitted: February 25, 2022
• First Posted: March 28, 2022
• Study Start: March 8, 2022
• Primary Completion: April 12, 2022
• Study Completion: April 12, 2022
• Last Updated: April 20, 2022

Record last verified: 2022-04

Data Sharing

• IPD Sharing: Will not share

Locations

DK (1)