NCT03275779

Brief Summary

This study will investigate whether manipulating resistance exercise frequency impacts muscle protein synthesis rates. The investigators will test the hypothesise that a higher resistance exercise frequency will result in greater muscle protein synthesis rates than a lower resistance exercise frequency.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
9

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Jan 2018

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

August 31, 2017

Completed
8 days until next milestone

First Posted

Study publicly available on registry

September 8, 2017

Completed
4 months until next milestone

Study Start

First participant enrolled

January 1, 2018

Completed
11 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2018

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2018

Completed
Last Updated

January 5, 2023

Status Verified

December 1, 2022

Enrollment Period

11 months

First QC Date

August 31, 2017

Last Update Submit

January 3, 2023

Conditions

Physical Activity

Outcome Measures

Primary Outcomes (1)

  • Change in muscle protein synthesis (FSR %/day)

    The change in muscle protein synthesis rates (FSR %/day) from baseline will be determined between the low and high frequency conditions at days 10 and 15 using deuterium oxide (D2O).

    At day 10 and 15.

Secondary Outcomes (1)

  • Change in satellite cell response

    At day 10 and 15.

Study Arms (2)

Low Frequency Condition

EXPERIMENTAL

Participants complete 7 days of habitual physical activity followed by a 7 day period where participants complete a single bout of unilateral resistance exercise.

Behavioral: Low Frequency Condition

High Frequency Condition

EXPERIMENTAL

Participants complete 7 days of habitual physical activity followed by a 7 day period where participants complete the same total volume of resistance exercise as the low frequency condition as five smaller bouts of unilateral resistance exercise.

Behavioral: High Frequency Condition

Interventions

Low Frequency ConditionBEHAVIORAL

Young, untrained participants complete 7 days of habitual physical activity followed by a 7 day period where participants complete a single bout of unilateral resistance exercise.

Low Frequency Condition
High Frequency ConditionBEHAVIORAL

Young, untrained participants complete 7 days of habitual physical activity followed by a 7 day period where participants complete the same total volume of resistance exercise as the low frequency condition as five smaller bouts of unilateral resistance exercise.

High Frequency Condition

Eligibility Criteria

Age18 Years - 35 Years
Sexmale(Gender-based eligibility)
Gender Eligibility DetailsParticipants must be male.
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Body mass index (18.5-29.99 kg/m2)
  • Untrained - defined as: Perform activities of daily living and recreation but have completed no regular lower body resistance-type exercise (e.g., weight training) activity in the last year.
  • Good general health

You may not qualify if:

  • Lidocaine allergy
  • Hypertension (≥140/90 mmHg)
  • Current participation in another clinical study
  • Previous participation in this study
  • Bleeding disorder/s
  • Current or recent smoker
  • Vegetarian or vegan
  • Past history of substance abuse and/or taking prescription or non-prescription medication (e.g., beta-blockers, insulin or thyroxine) or supplements that may influence normal metabolic responses.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

School of Sport Exercise and Rehabilitation Sciences, University of Birmingham

Birmingham, West Midlands, B15 2TT, United Kingdom

Location

MeSH Terms

Conditions

Motor Activity

Condition Hierarchy (Ancestors)

Behavior

Study Officials

  • Gareth Wallis, PhD

    University of Birmingham

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 31, 2017

First Posted

September 8, 2017

Study Start

January 1, 2018

Primary Completion

December 1, 2018

Study Completion

December 1, 2018

Last Updated

January 5, 2023

Record last verified: 2022-12

Data Sharing

IPD Sharing
Will not share

Locations

GB(1)