Lung Ultrasound in Detection of Extravascular Lung Water in Septic Patients.

NCT03676699 | Completed

• 1 other identifier: Ehab-Walaa.Ultrasound
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Sepsis is a common serious problem in surgical critical care units.Septic shock can be a consequence of severe sepsis with high mortality rate, in which there is major disturbance on the cellular, metabolic and circulatory levels.Patients who suffer from malignancy or under chemotherapeutic treatment are at higher risk of sepsis.Postoperative cancer patients carry both the risk of underlying malignancy with superimposed risk of major surgical procedure.\]. Monitoring effective fluid resuscitation and patient's hemodynamic status is achieved through different techniques mainly by measuring central venous pressure (CVP), pulmonary artery occlusion pressure (PAOP) and transpulmonary thermodilution along with chest radiography analysis .This study aims to investigate the correlation between lung ultrasound and IVC collapsibility index in assessment of fluid responsiveness in cancer patients with septic shock.

Conditions

Ultrasound Therapy; Complications

Keywords

Extravascular lung water, inferior vena cava collapsibility

Outcome Measures

Primary Outcomes (1)

• Detection of B-lines

  The number of B lines was scanned and a quadrant was considered to be positive when 3 or more B-Lines were recorded. A patient was defined to have positive B-lines (when 3 or more B-Lines are recorded in 3 or more quadrants).

  12 hours follow up

Interventions

Ultrasound chest DIAGNOSTIC_TEST

Ultrasound detection of extravascular lung water

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients meeting the inclusion criteria with severe sepsis and septic shock admitted to the intensive care unit.

You may qualify if:

• Patients aged between (18 - 65) years.
• Diagnosed with severe sepsis or septic shock according to the third international consensus definition (sepsis-3).
• All of them underwent major abdominal oncologic surgeries.

You may not qualify if:

• ASA III and IV patients.
• Patients with BMI\>35.
• Patients who suffered from chronic lung disease.
• History of cardiac or renal problems.
• Patients with lung cancer or pulmonary metastases.
• Patients with inserted chest tubes.
• Presence of subcutaneous emphysema.

Sponsors & Collaborators

• National Cancer Institute, Egypt: lead

Study Sites (1)

Department of Anesthesia and Pain medicine.National Cancer Institute

Cairo, 11796, Egypt

Location

Related Links

• Lung ultrasonography for the assessment of rapid extravascular water variation: evidence from hemodialysis patients.

Study Officials

• Ehab H Shaker, MD

  National Cancer Institute- Cairo University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: lecturer of anesthesia ,critical care and pain medicine

Study Record Dates

• First Submitted: September 17, 2018
• First Posted: September 19, 2018
• Study Start: March 30, 2018
• Primary Completion: August 30, 2018
• Study Completion: August 30, 2018
• Last Updated: September 19, 2018

Record last verified: 2018-09

Locations

EG (1)