The China Longitudinal Aging Study of Cognitive Impairment

NCT03672448 | Unknown

• 1 other identifier: CRC2017ZD02
• Study Type: observational
• Target: 10,000
• Locations: 1 country
• Sites: 1

Brief Summary

Alzheimer's disease (AD) and Vascular dementia (VaD) have become common diseases in the elderly. The burden of dementia is rising in China, with major medical, social and economic impacts. To address this important public health problem, cohort study on elderly cognitive disorders should be carry out. The methods of early prevention, early diagnosis and early treatment the cognitive disorders in elderly should be found to reduce the burden of the social and economic issue due to dementia. At present, the international corresponding guidelines have taken gene and brain imaging biomarkers as important indicators of dementia pathogenesis research, accurate diagnosis and targeted intervention. Based on the above understanding, the study carry out the population cohort study based on accurate diagnosis and construct the high standard information and sample bank. The study will establish the standard and quality system of geriatric cognitive disorders cohort study (unified standards and norms). The study will integrate the standard biological samples stratified acquisition function module (homogeneity and precision) of elderly cognitive disorders, and complete the construction of biological samples bank and clinical diagnosis and treatment information database. The study will apply and develop brain structural and pathological imaging technology to support precision diagnosis of senile cognitive disorders. The study will evaluate whether peripheral nerve degeneration can predict central nervous system degeneration based on the large cohort of elderly study. In addition, The study will make an effective supplement the sample bank construction of Shanghai Mental Health Center.

Conditions

Mild Cognitive Impairment; Alzheimer Disease; Dementia, Vascular; Dementia With Lewy Bodies; Dementia Frontal; Depression; Anxiety

Keywords

dementia; depression; cohort study; sample bank; precision diagnosis; brain imaging

Outcome Measures

Primary Outcomes (1)

• Prevalence, incidence of neurocognitive disorder

  Prevalence, incidence of neurocognitive disorder such as AD, MCI and other types of dementia

  5 years

Secondary Outcomes (2)

• Prevalence, incidence of mood disorder

  5 years

• conversion rate

  5 years

Study Arms (2)

Neurocognitive disorder

Dementias

Other: Naturalistic observation

Normal Aging

Normal Aging with normal cognitive function

Other: Naturalistic observation

Interventions

Naturalistic observation OTHER

Naturalistic observation

Also known as: Normal Aging

Neurocognitive disorder; Normal Aging

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

10,000 adult Chinese aged 60 and up who have been living Shanghai will be recruited.

You may qualify if:

• registered residents in the community;
• ≥ 60 years;
• without schizophrenia or mental retardation;
• be able to communicate and accept physical and cognitive examinations

You may not qualify if:

• blind
• deaf mute

Sponsors & Collaborators

• Shanghai Mental Health Center: lead

Study Sites (1)

Shanghai Mental Health Centre

Shanghai, Shanghai Municipality, 200030, China

RECRUITING

Related Publications (1)

• Wang T, He H, Shi Y, Su N, Zhu M, Yan F, Liu Y, Li J, Tang M, Chen W, Bao F, Wang H, Wang Y, Liu Y, Yuan Y, Zuo X, Zhang X, Cui L, Wu W, Zhang C, Lu Y, Fang Y, Xiao S. Prevalence, incidence and modifiable factors for subtypes of mild cognitive impairment: results from the Longitudinal Ageing Study in China. Gen Psychiatr. 2025 Mar 7;38(2):e101736. doi: 10.1136/gpsych-2024-101736. eCollection 2025.

  PMID: 40070969 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

DNA and mRNA

MeSH Terms

Conditions

Cognitive Dysfunction; Alzheimer Disease; Dementia, Vascular; Lewy Body Disease; Depression; Anxiety Disorders; Dementia

Interventions

Observational Studies as Topic

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tauopathies; Neurodegenerative Diseases; Cerebrovascular Disorders; Intracranial Arteriosclerosis; Intracranial Arterial Diseases; Leukoencephalopathies; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases; Cardiovascular Diseases; Parkinsonian Disorders; Basal Ganglia Diseases; Movement Disorders; Synucleinopathies; Behavioral Symptoms; Behavior

Intervention Hierarchy (Ancestors)

Clinical Studies as Topic; Epidemiologic Study Characteristics; Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Study Officials

• Huafang Li, M.D., Ph.D.

  Shanghai Mental Health Centre

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Shifu Xiao, M.D., Ph.D.

CONTACT

00862164387250; xiaoshifu@msn.com

Tao Wang, M.D., Ph.D.

CONTACT

00862164387250; wtshhwy@163.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 26, 2018
• First Posted: September 14, 2018
• Study Start: September 1, 2018
• Primary Completion: November 30, 2023
• Study Completion: November 30, 2023
• Last Updated: January 10, 2020

Record last verified: 2020-01

Locations

CN (1)