NCT07532122

Brief Summary

The goal of this observational study is to learn about the prevalence of postoperative anxiety and depression symptoms and identify the related risk factors in elderly patients aged 65 and older who undergo non-cardiac surgery in China. The main questions it aims to answer are: What is the prevalence rate of postoperative anxiety symptoms in elderly Chinese patients after non-cardiac surgery? What is the prevalence rate of postoperative depression symptoms in elderly Chinese patients after non-cardiac surgery? What are the risk and protective factors linked to postoperative anxiety and depression symptoms in this patient population? Participants will undergo routine non-cardiac surgery as part of their standard medical care, and researchers will collect relevant clinical data and assess their anxiety and depression symptoms using standardized screening scales after surgery.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
8,590

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jan 2020

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2020

Completed
2.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 30, 2022

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 30, 2022

Completed
3.9 years until next milestone

First Submitted

Initial submission to the registry

April 9, 2026

Completed
6 days until next milestone

First Posted

Study publicly available on registry

April 15, 2026

Completed
Last Updated

April 15, 2026

Status Verified

March 1, 2026

Enrollment Period

2.4 years

First QC Date

April 9, 2026

Last Update Submit

April 9, 2026

Conditions

DepressionAnxiety

Outcome Measures

Primary Outcomes (2)

  • Depression

    Primary outcomes were depression Patient Health Questionnaire 9 (PHQ-9).The PHQ-9 is a nine-item questionnaire for screening on the presence of depressive symptoms and monitoring depression severity. Items were scored on a four-point scale with total scores ranging from zero to twenty-seven. Scores were defined as: ≥5 mild, ≥10 moderate, and ≥15 severe level of depression. The recommended screening cutoff was ≥10, corresponding with at least a moderate level of depression. The higher the score, the worse the situation. The total score ranges from 0 to 27, and higher scores indicate more depressive symptoms.

    within 7 days after surgery

  • Anxiety

    The GAD-7 is a seven-item questionnaire for screening on the presence of generalized anxiety disorder and assessing its severity. Items were scored on a four-point scale with total scores ranging from zero to twenty-one. Scores were defined as: ≥5 mild, ≥10 moderate, and ≥15 severe anxiety. The recommended screening cutoff was ≥10, corresponding with at least a moderate level of anxiety. Higher scores mean more anxiety.

    within 7 days after surgery

Eligibility Criteria

Age65 Years+
Sexall
Age GroupsOlder Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Elderly patients (aged ≥ 65 years) who completed the anxiety and depression assessment after the elective noncardiac, non-neurosurgical surgery were included in this study.

You may qualify if:

  • elderly patients (age ≥ 65 years)
  • undergoing elective surgery with a planned overnight hospital stay following surgery
  • non-cardiac surgery, non-neurosurgical surgery
  • patients who complete the scale assessment

You may not qualify if:

  • patients fully refused to participate in the study
  • patients with severe dementia, language disorder, severe hearing or visual impairment, coma, and end-stage status
  • patients whose surgeries were canceled
  • history of previous severe mental illness or long-term use of psychotropic medications
  • patients admitted to ICU immediately after surgery
  • patients who died within 7 days after surgery

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

First Medical center of Chinese PLA General Hospital

Beijing, Beijing Municipality, 100853, China

Location

MeSH Terms

Conditions

DepressionAnxiety Disorders

Condition Hierarchy (Ancestors)

Behavioral SymptomsBehaviorMental Disorders

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Director (Cheif expert of National key research and development program of China 2018YFC2001900)

Study Record Dates

First Submitted

April 9, 2026

First Posted

April 15, 2026

Study Start

January 1, 2020

Primary Completion

May 30, 2022

Study Completion

May 30, 2022

Last Updated

April 15, 2026

Record last verified: 2026-03

Locations

CN(1)