Evidence Amyloid Scan EEG Study

NCT03644043 | Unknown DMC FDA Device

• 1 other identifier: 1R02TCR0072518
• Study Type: observational
• Target: 2,000
• Locations: 1 country
• Sites: 1

Brief Summary

The Evidence Amyloid Study EEG (EASE) establishes an open-label, longitudinal cohort study to measure of neurological functioning during the onset and progression of cognitive decline in preclinical Alzheimer's patients using quantitative electroencephalography (qEEG) measures (P300, P50, and reaction time). Participants will be scanned using the ElectroCap (FDA Class II) and/or the WAVi headset with the WAVi EEG P300/P50 system, along with the structured clinical interviews and assessments for baseline screening or mild cognitive impairment which are standard of care.

Conditions

Alzheimer Disease; Dementia Frontal; Mild Cognitive Impairment

Outcome Measures

Primary Outcomes (1)

• Patient meeting Appropriate Use Criteria (AUC) with EEG brain scan - P300 and P50 will be measured for correlation between P300 and P50 with amyloid deposition.

  Test whether qEEG P300 and P50 waveform amplitudes and auditory response times will lead to correlation with amyloid deposition

  10 days

Study Arms (1)

Early stage of MCI symptoms

Subjects with cognitive decline representing MCI symptomology and with previous PET amyloid-beta (Aβ) imaging results.

Device: EEG scan

Interventions

EEG scan DEVICE

WAVi EEG and evoked potential platform. Participants will be scanned using the ElectroCap (FDA Class II) and/or the WAVi Headset with the WAVi Co EEG P300 system, along with the structured clinical interviews and assessments for the various ailments or baseline screenings

Early stage of MCI symptoms

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Participants must be referred by qualified dementia specialists for EEG brain scan.

You may qualify if:

• and older;
• Medicare beneficiary;
• Diagnosis of MCI or dementia, according to DSM-IV and/or National Institutes of Aging-Alzheimer's Association criteria, verified by a dementia specialist within 24 months (American Psychiatric Association. 2000; McKhann et al. 2011; Albert et al. 2011);
• Cognitive complaint verified by objectively confirmed cognitive impairment;

You may not qualify if:

• Head MRI and/or CT within 24 months prior to enrollment;
• Normal cognition or subjective complaints that are not verified by cognitive testing.
• Knowledge of amyloid status, in the opinion of the referring dementia expert, may cause significant psychological harm or otherwise negatively impact the patient or family.
• Scan being ordered for nonmedical purposes (e.g., legal, insurance coverage, or employment screening).
• Cancer requiring active therapy (excluding non-melanoma skin cancer);
• Life expectancy less than 24 months based on medical co-morbidities;
• Residence in a skilled nursing facility.

Sponsors & Collaborators

• Metabolic Therapy Inc.: lead
• Institute of Asian American Adult Development: collaborator

Study Sites (1)

Translational Cognitive Research

Houston, Texas, 77036, United States

RECRUITING

Related Publications (22)

• Smailovic U, Koenig T, Kareholt I, Andersson T, Kramberger MG, Winblad B, Jelic V. Quantitative EEG power and synchronization correlate with Alzheimer's disease CSF biomarkers. Neurobiol Aging. 2018 Mar;63:88-95. doi: 10.1016/j.neurobiolaging.2017.11.005. Epub 2017 Nov 16.

  PMID: 29245058 BACKGROUND

• Kramberger MG, Kareholt I, Andersson T, Winblad B, Eriksdotter M, Jelic V. Association between EEG abnormalities and CSF biomarkers in a memory clinic cohort. Dement Geriatr Cogn Disord. 2013;36(5-6):319-28. doi: 10.1159/000351677. Epub 2013 Sep 10.

  PMID: 24022277 BACKGROUND

• Stomrud E, Hansson O, Minthon L, Blennow K, Rosen I, Londos E. Slowing of EEG correlates with CSF biomarkers and reduced cognitive speed in elderly with normal cognition over 4 years. Neurobiol Aging. 2010 Feb;31(2):215-23. doi: 10.1016/j.neurobiolaging.2008.03.025.

  PMID: 18462837 BACKGROUND

• Michel CM. Electrical Neuroimaging. Cambridge University Press, Cambridge 2009.

  BACKGROUND

• Freire FR, Coelho F, Lacerda JR, da Silva MF, Goncalves VT, Machado S, Velasques B, Ribeiro P, Basile LFH, Oliveira AMP, Paiva WS, Kanda PAM, Anghinah R. Cognitive rehabilitation following traumatic brain injury. Dement Neuropsychol. 2011 Jan-Mar;5(1):17-25. doi: 10.1590/S1980-57642011DN05010004.

  PMID: 29213715 BACKGROUND

• 1. Cassani R, Falk TH, Fraga FJ, Cecchi M, Moore DK, Anghinah R. Towards automated electroencephalography-based Alzheimer's disease diagnosis using portable low-density devices. Biomedical Signal Processing and Control. 2017,33:261-71.

  BACKGROUND

• Pratap-Chand R, Sinniah M, Salem FA. Cognitive evoked potential (P300): a metric for cerebral concussion. Acta Neurol Scand. 1988 Sep;78(3):185-9. doi: 10.1111/j.1600-0404.1988.tb03643.x.

  PMID: 3227804 BACKGROUND

• Olichney JM, Yang JC, Taylor J, Kutas M. Cognitive event-related potentials: biomarkers of synaptic dysfunction across the stages of Alzheimer's disease. J Alzheimers Dis. 2011;26 Suppl 3(0 3):215-28. doi: 10.3233/JAD-2011-0047.

  PMID: 21971462 BACKGROUND

• Cecchi M, Moore DK, Sadowsky CH, Solomon PR, Doraiswamy PM, Smith CD, Jicha GA, Budson AE, Arnold SE, Fadem KC. A clinical trial to validate event-related potential markers of Alzheimer's disease in outpatient settings. Alzheimers Dement (Amst). 2015 Oct 2;1(4):387-94. doi: 10.1016/j.dadm.2015.08.004. eCollection 2015 Dec.

  PMID: 27239520 BACKGROUND

• van Dinteren R, Arns M, Jongsma ML, Kessels RP. P300 development across the lifespan: a systematic review and meta-analysis. PLoS One. 2014 Feb 13;9(2):e87347. doi: 10.1371/journal.pone.0087347. eCollection 2014.

  PMID: 24551055 BACKGROUND

• Polich J, Corey-Bloom J. Alzheimer's disease and P300: review and evaluation of task and modality. Curr Alzheimer Res. 2005 Dec;2(5):515-25. doi: 10.2174/156720505774932214.

  PMID: 16375655 BACKGROUND

• Polich J, Ladish C, Bloom FE. P300 assessment of early Alzheimer's disease. Electroencephalogr Clin Neurophysiol. 1990 May-Jun;77(3):179-89. doi: 10.1016/0168-5597(90)90036-d.

  PMID: 1691970 BACKGROUND

• Frodl T, Hampel H, Juckel G, Burger K, Padberg F, Engel RR, Moller HJ, Hegerl U. Value of event-related P300 subcomponents in the clinical diagnosis of mild cognitive impairment and Alzheimer's Disease. Psychophysiology. 2002 Mar;39(2):175-81. doi: 10.1017/S0048577202010260.

  PMID: 12212666 BACKGROUND

• Bennys K, Portet F, Touchon J, Rondouin G. Diagnostic value of event-related evoked potentials N200 and P300 subcomponents in early diagnosis of Alzheimer's disease and mild cognitive impairment. J Clin Neurophysiol. 2007 Oct;24(5):405-12. doi: 10.1097/WNP.0b013e31815068d5.

  PMID: 17912065 BACKGROUND

• Papaliagkas VT, Anogianakis G, Tsolaki MN, Koliakos G, Kimiskidis VK. Combination of P300 and CSF beta-amyloid(1-42) assays may provide a potential tool in the early diagnosis of Alzheimer's disease. Curr Alzheimer Res. 2010 Jun;7(4):295-9. doi: 10.2174/156720510791162421.

  PMID: 19939224 BACKGROUND

• Korzyukov O, Pflieger ME, Wagner M, Bowyer SM, Rosburg T, Sundaresan K, Elger CE, Boutros NN. Generators of the intracranial P50 response in auditory sensory gating. Neuroimage. 2007 Apr 1;35(2):814-26. doi: 10.1016/j.neuroimage.2006.12.011. Epub 2006 Dec 19.

  PMID: 17293126 BACKGROUND

• Golob EJ, Johnson JK, Starr A. Auditory event-related potentials during target detection are abnormal in mild cognitive impairment. Clin Neurophysiol. 2002 Jan;113(1):151-61. doi: 10.1016/s1388-2457(01)00713-1.

  PMID: 11801437 BACKGROUND

• Green DL, Payne L, Polikar R, Moberg PJ, Wolk DA, Kounios J. P50: A candidate ERP biomarker of prodromal Alzheimer's disease. Brain Res. 2015 Oct 22;1624:390-397. doi: 10.1016/j.brainres.2015.07.054. Epub 2015 Aug 6.

  PMID: 26256251 BACKGROUND

• Boutros NN, Belger A. Midlatency evoked potentials attenuation and augmentation reflect different aspects of sensory gating. Biol Psychiatry. 1999 Apr 1;45(7):917-22. doi: 10.1016/s0006-3223(98)00253-4.

  PMID: 10202580 BACKGROUND

• Amenedo E, Diaz F. Ageing-related changes in the processing of attended and unattended standard stimuli. Neuroreport. 1999 Aug 2;10(11):2383-8. doi: 10.1097/00001756-199908020-00030.

  PMID: 10439468 BACKGROUND

• Azumi T, Nakashima K, Takahashi K. Aging effects on auditory middle latency responses. Electromyogr Clin Neurophysiol. 1995 Nov;35(7):397-401.

  PMID: 8549430 BACKGROUND

• Hubl D, Kleinlogel H, Frolich L, Weinandi T, Maurer K, Holstein W, Czekalla J, Dierks T. Multilead quantitative electroencephalogram profile and cognitive evoked potentials (P300) in healthy subjects after a single dose of olanzapine. Psychopharmacology (Berl). 2001 Nov;158(3):281-8. doi: 10.1007/s002130100861.

  PMID: 11713618 BACKGROUND

MeSH Terms

Conditions

Alzheimer Disease; Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Dementia; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tauopathies; Neurodegenerative Diseases; Neurocognitive Disorders; Mental Disorders; Cognition Disorders

Central Study Contacts

Dewey Brown II, PhD

CONTACT

2145174004; kruss3@gmail.com

Kenneth O Russell

CONTACT

5129097963; kruss3@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 24 Months
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 14, 2018
• First Posted: August 23, 2018
• Study Start: July 20, 2018
• Primary Completion: November 15, 2020
• Study Completion: November 30, 2020
• Last Updated: August 23, 2018

Record last verified: 2018-08

Locations

US (1)