Analysis of Dentine Sialophosphoprotein (DSPP) for Root Resorption
Dentine Sialophosphoprotein (DSPP) Quantification for Root Resorption Prediction Using Multivariate Versus Univariate Spectrum Analysis
1 other identifier
observational
30
1 country
1
Brief Summary
This study was conducted after obtaining approval from UKM Research Ethics Committee. Gingival Crevicular Fluid (GCF) from Orthodontic and non-orthodontic patients was collected with the consent of patients to detect Dentine sialophosphoprotein. Spectrometry analysis of Gingival Crevicular Fluid was conducted in collaboration with MIMOS Berhad.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Sep 2018
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 14, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 14, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
March 12, 2020
CompletedFirst Submitted
Initial submission to the registry
September 30, 2021
CompletedFirst Posted
Study publicly available on registry
October 14, 2021
CompletedOctober 15, 2021
October 1, 2021
1.2 years
September 30, 2021
October 13, 2021
Conditions
Keywords
Outcome Measures
Primary Outcomes (3)
value of wavelength of DSPP in GCF from non-orthodontic patient with no root resorption
The absorbance values at a single wavelength at 450 nm
1 month
value of wavelength of DSPP in GCF from orthodontic patient with mild to moderate root resorption
The absorbance values at a single wavelength at 450 nm
1 month
value of wavelength of DSPP in GCF from child patient severe root resorption
The absorbance values at a single wavelength at 450 nm
1 month
Study Arms (3)
normal
Patients with non-orthodontic treatment and have no root resorption
mild to moderate
Patients with orthodontic treatment and have mild to moderate root resorption
severe
Child patients with non-orthodontic treatment and have severe root resorption
Interventions
quantification of DSPP
Eligibility Criteria
Patients that come to the dental clinic for treatment
You may qualify if:
- good general health,
- good periodontal health,
- caries-free,
- good oral hygiene
You may not qualify if:
- Consumption of anti-inflammatory drugs and antibiotics
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Faculty of Dentistry
Kuala Lumpur, 50300, Malaysia
Related Publications (1)
Mohd Zain MN, Md Yusof Z, Basri KN, Yazid F, Teh YX, Ashari A, Zainal Ariffin SH, Megat Abdul Wahab R. Multivariate versus univariate spectrum analysis of dentine sialophosphoprotein (DSPP) for root resorption prediction: a clinical trial. BMC Oral Health. 2022 Apr 29;22(1):151. doi: 10.1186/s12903-022-02178-2.
PMID: 35488332DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Rohaya Megat Abdul Wahab, Master
Faculty of Dentistry, Universiti Kebangsaan Malaysia
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
September 30, 2021
First Posted
October 14, 2021
Study Start
September 14, 2018
Primary Completion
December 14, 2019
Study Completion
March 12, 2020
Last Updated
October 15, 2021
Record last verified: 2021-10