Investigating Memory in Healthy Subjects Using Transcranial Direct Current Stimulation

NCT03564353 | Completed Results FDA Device

• 1 other identifier: 17-34 CM
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to investigate whether we can improve associative memory performance in healthy subjects, by applying transcranial Direct Current Stimulation (tDCS) during a verbal paired-associate learning task

Conditions

Healthy Adults

Keywords

transcranial Direct Current Stimulation (tDCS); memory

Outcome Measures

Primary Outcomes (1)

• Associative Memory Assessed by a Verbal Paired-Associate Test

  Participants got the opportunity to learn the list of 75-word pairs across a total of eight alternating study (S) and test (T) periods. Participants came back for a final test session (all 75 words tested) 7 days later and were asked to give the English translations of Swahili words. A score was calaculated based on the percentage of words (English trnaslations) correctly recalled words.

  Baseline and 1 week after the tDCS

Study Arms (4)

memory task with tDCS location 1

EXPERIMENTAL

memory task paired with tDCS targeting C2 nerve (anode left c2; cathode right C2)

Device: tDCS

memory task with tDCS location 2

EXPERIMENTAL

memory task paired with tDCS targeting C2 nerve (anode right c2; cathode left C2)

Device: tDCS

memory task with tDCS location 3

EXPERIMENTAL

memory task paired with tDCS targeting C5/6 nerve

Device: tDCS

memory task with tDCS location 4

EXPERIMENTAL

memory task paired with tDCS targeting trigeminal nerve dermatomes (left and right temple/jaw)

Device: tDCS

Interventions

tDCS DEVICE

tDCS

memory task with tDCS location 1; memory task with tDCS location 2; memory task with tDCS location 3; memory task with tDCS location 4

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Age: 18-35 years
• Native English Speaker

You may not qualify if:

• History of severe head injuries, epileptic insults, or heart disease.
• Severe psychiatric disorders and severe untreated medical problems.
• acquainted with the foreign language used in the learning task
• Contraindications for tDCS (pregnant women, implanted devices)

Sponsors & Collaborators

• The University of Texas at Dallas: lead

Study Sites (1)

The University of Texas of Dallas

Richardson, Texas, 75080, United States

Location

MeSH Terms

Interventions

Transcranial Direct Current Stimulation

Intervention Hierarchy (Ancestors)

Electric Stimulation Therapy; Therapeutics; Convulsive Therapy; Psychiatric Somatic Therapies; Behavioral Disciplines and Activities; Electroshock; Psychological Techniques

Results Point of Contact

• Title: Clinical Trial Manager
• Organization: UT Dallas

Sarah.McLeod@utdallas.edu

972-883-7277

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Model Details: Participants will be randomly assigned to one of four groups: (1) tDCS targeting location 1 paired with memory task (2) tDCS targeting location 2 with memory task (3) tDCS targeting location 3 paired with memory task (4) tDCS targeting location 4 paired with memory task

Study Record Dates

• First Submitted: June 10, 2018
• First Posted: June 20, 2018
• Study Start: June 7, 2018
• Primary Completion: January 25, 2022
• Study Completion: January 25, 2022
• Last Updated: February 3, 2022
• Results First Posted: September 11, 2020

Record last verified: 2022-01

Locations

US (1)