Investigating the Neural Correlates in Memory Retrieval After HD-tDCS

NCT03319134 | Completed Results FDA Device

• 1 other identifier: 18-01
• Study Type: interventional
• Target: 45
• Locations: 1 country
• Sites: 1

Brief Summary

The overall objective of this study is to investigate the neural correlate in retrieval memory task. The aim of the study is to understand the undergoing changes in late positive ERP component during retrieval memory task when stimulating the posterior cingulate cortex (PCC) with High Definition Transcranial Direct Current Stimulation (HD-tDCS).

Conditions

Healthy Adults

Outcome Measures

Primary Outcomes (1)

• Recognition Memory Assessed by a Retrieval Memory Experiment

  Participants had to learn an association between a face and a name. The face-name association memory task was divided into (1) an encoding phase, (2) a consolidation phase, and (3) a retrieval phase. During the encoding phase, participants studied 60 successively presented face-name pairs. Participants were instructed to assess the gender of each face shown to keep participants focused on the task. The encoding phase lasted approximately 5 minutes. This is followed by a consolidation phase where participants were instructed to "sit still, relax, and think about nothing in particular" for 10 minutes. During the retrieval phase, participants were presented with 60 old and 60 new faces and were instructed to assess whether they had seen this face during the encoding phase, or if it was a 'new' face. Participants received active or sham transcranial direct current stimulation targetting the posterior cingulate cortex during retrieval. The outcome is correctly recalled old faces.

  Retrieval Memory is assessed after 90 seconds break following the recognition phase.

Study Arms (3)

active anodal HD-tDCS

EXPERIMENTAL

Active anodal HD-tDCS stimulation applied during memory task

Device: active anodal HD-tDCS

sham HD-tDCS

SHAM COMPARATOR

Sham HD-tDCS stimulation during memory task for comparison

Device: sham HD-tDCS

active cathodal HD-tDCS

EXPERIMENTAL

Active cathodal HD-tDCS stimulation applied during memory task

Device: active cathodal HD-tDCS

Interventions

active anodal HD-tDCS DEVICE

1\) active anodal HD-tDCS with memory task

active anodal HD-tDCS

sham HD-tDCS DEVICE

2\) sham HD-tDCS with memory task

sham HD-tDCS

active cathodal HD-tDCS DEVICE

3\) active cathodal HD-tDCS with memory task

active cathodal HD-tDCS

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Native English Speaker
• Currently not using any medication
• Capable of understanding and signing an informed consent

You may not qualify if:

• Severe disease
• Mental illness
• Cardiac history
• History of severe head injuries
• History of epileptic seizures
• Any implanted devices such as pacemaker, neurostimulator
• Pregnancy

Sponsors & Collaborators

• The University of Texas at Dallas: lead

Study Sites (1)

University of Texas at Dallas

Richardson, Texas, 75080, United States

Location

Results Point of Contact

• Title: Clinical Trial Manager
• Organization: UT Dallas

Sarah.McLeod@utdallas.edu

9723337277

Study Officials

• Sven Vanneste

  The University of Texas at Dallas

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate professor

Model Details: Participants will be randomly assigned to one of three groups: (1) active HD-tDCS with retrieval memory task, (2) sham HD-tDCS with retrieval memory task, (3) active cathodal HD-tDCS with retrieval memory task

Study Record Dates

• First Submitted: October 18, 2017
• First Posted: October 24, 2017
• Study Start: September 18, 2017
• Primary Completion: January 1, 2020
• Study Completion: January 30, 2020
• Last Updated: August 26, 2020
• Results First Posted: August 26, 2020

Record last verified: 2020-08

Locations

US (1)