1-1-8 Wash-in for Sevoflurane Low Flow Anesthesia

NCT03510013 | Completed

• 1 other identifier: HE601228
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators propose a new wash-in technique for sevoflurane low flow anesthesia with fresh gas flow of O2:N2O or O2:air 1:1 L/min with sevoflurane 8%. The objective of this study is to identify time to achieve alveolar concentration of sevoflurane at 1, 1.5, 2, 2.5, 3, and 3.5%

Conditions

Anesthesia

Keywords

low flow anesthesia; wash-in; sevoflurane

Outcome Measures

Primary Outcomes (1)

• Time

  Time (in second) to achieve alveolar concentration of sevoflurane 1, 1.5, 2, 2.5, 3, and 3.5%

  participants will be followed until alveolar concentration of sevoflurane reaches 3.5%, as expected of 10 minutes

Secondary Outcomes (2)

• Heart rate

  participants will be followed until alveolar concentration of sevoflurane reaches 3.5%, as expected of 10 minutes]

• Blood pressure

  participants will be followed until alveolar concentration of sevoflurane reaches 3.5%, as expected of 10 minutes]

Study Arms (1)

1-1-8 wash-in

EXPERIMENTAL

Wash-in using O2:N2O or O2:air 1:1 L/min with sevoflurane 8%

Procedure: 1-1-8 wash-in; Drug: Sevoflurane

Interventions

1-1-8 wash-in PROCEDURE

wash-in phase during start of low flow anesthesia

1-1-8 wash-in

Sevoflurane DRUG

Drug used for wash-in protocol

Also known as: Inhalation anesthetic

1-1-8 wash-in

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• ASA classification I-II
• age 18-65 years

You may not qualify if:

• BMI \> 35
• contraindicated for N2O
• with pulmonary or cardiac disease

Sponsors & Collaborators

• Khon Kaen University: lead

Study Sites (1)

Faculty of Medicine, Khon Kaen University

Khon Kaen, 40002, Thailand

Location

Related Publications (1)

• Tribuddharat S, Sathitkarnmanee T, Vattanasiriporn N, Thananun M, Nonlhaopol D, Somdee W. 1-1-8 one-step sevoflurane wash-in scheme for low-flow anesthesia: simple, rapid, and predictable induction. BMC Anesthesiol. 2020 Jan 24;20(1):23. doi: 10.1186/s12871-020-0940-2.

  PMID: 31980020 DERIVED

MeSH Terms

Interventions

Sevoflurane; Anesthetics, Inhalation

Intervention Hierarchy (Ancestors)

Methyl Ethers; Ethers; Organic Chemicals; Hydrocarbons, Fluorinated; Hydrocarbons, Halogenated; Hydrocarbons; Anesthetics, General; Anesthetics; Central Nervous System Depressants; Physiological Effects of Drugs; Pharmacologic Actions; Chemical Actions and Uses; Central Nervous System Agents; Therapeutic Uses

Study Officials

• Thepakorn Sathitkarnmanee, MD

  Faculty of Medicine, Khon Kaen University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Model Details: All participants will receive sevoflurane 8% with O2:N2O or O2:air 1:1 L/min under controlled ventilation. Time to achieve alveolar concentration of sevoflurane of 1%, 1.5%, 2%, 2.5%, 3% and 3.5% will be recorded.

Study Record Dates

• First Submitted: April 17, 2018
• First Posted: April 27, 2018
• Study Start: April 1, 2018
• Primary Completion: May 31, 2018
• Study Completion: May 31, 2018
• Last Updated: August 8, 2018

Record last verified: 2018-08

Data Sharing

• IPD Sharing: Will not share

Locations

TH (1)