Blood, Muscle and Exercise Responses to Sodium Bicarbonate Supplementation

NCT03505970 | Unknown

• 1 other identifier: SB_BloodMuscle
• Study Type: interventional
• Target: 15
• Locations: 0 countries
• Sites: N/A

Brief Summary

The aim of this study is to evaluate the changes in activity of transporters of H+ (monocarboxylate transporters; MCT1, MCT4, NHE) following sodium bicarbonate supplementation and subsequent exercise performance. Fifteen healthy men (age 18-35 years) will be invited to attend the laboratory on five separate visits to a randomized, double-blind, placebo-controlled study. Participants will be supplemented with a 0.3 g/kg dose of sodium bicarbonate or placebo (Analytical Pharmacy, Brazil) in opaque gelatin capsules. One hour after supplementation they will perform a 1-km time trial and every 10 minutes a blood sample will be collected. A muscle biopsy will be taken prior to supplementation, immediately prior to exercise, and immediately post-exercise. A questionnaire will be also used to evaluate the side-effects associated with sodium bicarbonate supplementation. Muscle and blood samples will be analysed for acidity and H+ and muscle samples will be analysed for H+ transporters (MCT1, MCT4, NHE).

Conditions

Sports Nutritional Physiological Phenomena

Keywords

Physiological Phenomena

Outcome Measures

Primary Outcomes (1)

• H+ transporter activity

  Change in activity of transporters related to H+

  5 minutes Post-exercise

Secondary Outcomes (1)

• Exercise performance

  1 hour Post-supplementation

Study Arms (2)

Sodium bicarbonate

EXPERIMENTAL

0.3 g∙kg-1body mass of sodium bicarbonate

Dietary Supplement: Sodium bicarbonate

Placebo

PLACEBO COMPARATOR

Individuals will ingest 0.3 g/kg maltodextrin before undergoing exercise

Dietary Supplement: Maltodextrin

Interventions

Sodium bicarbonate DIETARY_SUPPLEMENT

Sodium bicarbonate in powder form ingested in gelatine capsules. This leads to an increase bicarbonate concentration in blood, increasing buffering capacity which may lead to improvements in exercise

Sodium bicarbonate

Maltodextrin DIETARY_SUPPLEMENT

Maltodextrin will be used as a placebo as it will not lead to any increases in circulating bicarbonate and, at this dose, will not likely have any physiological effect.

Placebo

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy males

You may not qualify if:

• Smokers
• Chronic disease
• Prior or current use of steroids
• Use of creatine in the last 6 months
• Use of beta-alanine in the last 6 months

Sponsors & Collaborators

• University of Sao Paulo: lead

MeSH Terms

Interventions

Sodium Bicarbonate; maltodextrin

Intervention Hierarchy (Ancestors)

Bicarbonates; Carbonates; Carbonic Acid; Carbon Compounds, Inorganic; Inorganic Chemicals; Sodium Compounds

Central Study Contacts

Bruno Gualano, PhD

CONTACT

3061-8789; gualano@usp.br

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: Double-blind crossover

Study Record Dates

• First Submitted: March 31, 2018
• First Posted: April 23, 2018
• Study Start: August 1, 2019
• Primary Completion: November 1, 2020
• Study Completion: December 1, 2020
• Last Updated: June 6, 2019

Record last verified: 2019-06