Consistencies in Responses to Sodium Bicarbonate?
1 other identifier
interventional
15
1 country
1
Brief Summary
Intervention studies do not account for high within-individual variation potentially compromising the magnitude of an effect. Repeat administration of a treatment allows quantification of individual responses and determination of the consistency of responses. The investigators aim to determine the consistency of metabolic and exercise responses following repeated administration of sodium bicarbonate (SB). Design and Methods: 15 physically active males will complete six cycling capacity tests at 110% of maximum power output (CCT110%) following ingestion of either 0.3 g∙kg-1Body Mass of SB (4 trials) or placebo (PL, 2 trials). Blood pH, bicarbonate, base excess and lactate will be determined at baseline, pre-exercise, post-exercise and 5-min post-exercise. Total work done (TWD) will be recorded as the exercise outcome.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Nov 2013
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
November 1, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2014
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2014
CompletedFirst Submitted
Initial submission to the registry
June 8, 2015
CompletedFirst Posted
Study publicly available on registry
June 18, 2015
CompletedJune 18, 2015
June 1, 2015
7 months
June 8, 2015
June 17, 2015
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
blood pH
5 min after a physical exercise test
Secondary Outcomes (3)
blood bicarbonate
5 min after a physical exercise test
blood lactate
5 min after a physical exercise test
anaerobic exercise capacity
4 hours after supplementation
Study Arms (2)
Placebo
PLACEBO COMPARATOR0.3 g∙kg-1body mass of calcium carbonate
Sodium bicarbonate
EXPERIMENTAL0.3 g∙kg-1body mass of sodium bicarbonate
Interventions
Eligibility Criteria
You may qualify if:
- recreationally active males
You may not qualify if:
- use of dietary supplements in the past 6 months
- the presence of any musculoskeletal disorder
- the use of anabolic steroids
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University of Sao Paulo
São Paulo, São Paulo, 05508-30, Brazil
Related Publications (1)
Froio de Araujo Dias G, da Eira Silva V, de Salles Painelli V, Sale C, Giannini Artioli G, Gualano B, Saunders B. (In)Consistencies in Responses to Sodium Bicarbonate Supplementation: A Randomised, Repeated Measures, Counterbalanced and Double-Blind Study. PLoS One. 2015 Nov 17;10(11):e0143086. doi: 10.1371/journal.pone.0143086. eCollection 2015.
PMID: 26574755DERIVED
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- TRIPLE
- Who Masked
- PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
June 8, 2015
First Posted
June 18, 2015
Study Start
November 1, 2013
Primary Completion
June 1, 2014
Study Completion
June 1, 2014
Last Updated
June 18, 2015
Record last verified: 2015-06