The Influence of Melatonin Supplementation in the Group of Persons Performing Competitive Sport.

NCT03505411 | Completed

• 1 other identifier: KB 586/2009
• Study Type: interventional
• Target: 81
• Locations: 0 countries
• Sites: N/A

Brief Summary

The research aims to determine the impact of 30-day supplementation of melatonin on the antioxidative defense mechanisms and the release of markers of oxidative stress and inflammation in rowers and footballers undergoing training of submaximal intensity.

Conditions

Antioxidants; Oxidative Stress; Inflammation; Lipid Peroxidation

Keywords

Melatonin; Glutathione; Glutathione peroxidase; Malondialdehyde; Isoprostanes; anti-ox-LDL; Superoxide dismutase; Glutathione reductase; Interleukin-6; C-reactive protein; Autonomic nervous system

Outcome Measures

Primary Outcomes (1)

• Measurement of oxidative stress parameters and inflammatory markers concentration before melatonin administration, at baseline.

  The study was conducted in football players and rowers and the control group. Samples of blood from the basilic vein were taken once, from both the control group and the athletes at baseline. In blood serum, the ELISA method was used to determine the concentrations of melatonin, isoprostanes (8-iso-PGF2α), anti-ox-LDL antibodies, interleukin-6 and C-reactive protein (CRP). In red blood cells, the concentration of reduced glutathione (GSH), thiobarbituric acid reactive substances (malondialdehyde, MDA) were determined and the activity of glutathione peroxidase (GSH-Px), cytoplasmic superoxide dismutase (SOD-1) and glutathione reductase (GR) were determined.

  1 day

Secondary Outcomes (1)

• Changes in oxidative stress parameters and inflammatory markers concentration afer 30 days of melatonin administration in athletes.

  30 day

Study Arms (1)

melatonin, submaximal effort

EXPERIMENTAL

1 arm 5 mg melatonin 1 hr before bedtime for 30 days

Dietary Supplement: melatonin supplementation

Interventions

melatonin supplementation DIETARY_SUPPLEMENT

melatonin, submaximal effort

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• sign informed consent form for participation in the study

You may not qualify if:

• diseases
• the participants will not be minor and incapacitated persons, soldiers, prisoners and persons dependent in any way from the investigators

Sponsors & Collaborators

• Nicolaus Copernicus University: lead

MeSH Terms

Conditions

Inflammation

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Jolanta Czuczejko

  Department of Positron Emission Tomography and Molcecular Diagnostics, Collegium Medicum of Nicolaus Copernicus University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant professor

Study Record Dates

• First Submitted: March 28, 2018
• First Posted: April 23, 2018
• Study Start: January 15, 2010
• Primary Completion: December 31, 2012
• Study Completion: December 31, 2012
• Last Updated: April 23, 2018

Record last verified: 2018-03

Data Sharing

• IPD Sharing: Will not share