Study on Whether Tart Cherry Juice Can Reduce Oxidative Stress and Inflammation
Effects of Tart Cherry Juice on Oxidative Stress and Inflammation in Older Men and Women
1 other identifier
interventional
12
1 country
1
Brief Summary
Oxidative stress has been linked to many diseases associated with aging, including coronary heart disease and Alzheimer's disease. Antioxidants and special proteins in the body work together to help prevent damage by free radicals. Some studies have indicated that as people age, they are less able to fight off oxidative stress and have increased levels of inflammation. Tart cherries are known to be rich in antioxidants and plant-nutrients. The product we are using in this study is an all-natural tart cherry juice, mixed with apple juice concentrate and containing no additives and no preservatives. We hope to learn whether antioxidant supplementation, such as tart cherry juice, can measurably decrease oxidative damage and inflammation associated with aging.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Oct 2007
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 1, 2007
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2008
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 2008
CompletedFirst Submitted
Initial submission to the registry
February 17, 2009
CompletedFirst Posted
Study publicly available on registry
February 19, 2009
CompletedFebruary 19, 2009
February 1, 2009
6 months
February 17, 2009
February 18, 2009
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
plasma F2-isoprostane response to a forearm ischemia-reperfusion challenge.
Secondary Outcomes (1)
Urinary markers of oxidative damage.
Interventions
Eligibility Criteria
You may qualify if:
- men and women, ages 55-80y, in good health, with \>8 years of education
- non-smoker
- able to give informed consent
You may not qualify if:
- use of anti-oxidant supplements, in excess of a standard multi-vitamins
- current hormone replacement therapy
- any history of significant chronic disease
- uncontrolled hypertension
- body mass index (BMI) \> 30 kg/m2
- high physical activity level, as determined by questions on the screening questionnaire
- use of anti-inflammatory medication
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Kronos Longevity Research Institutelead
- Vanderbilt Universitycollaborator
Study Sites (1)
Kronos Longevity Research Institute
Phoenix, Arizona, 85016, United States
Related Publications (1)
Traustadottir T, Davies SS, Stock AA, Su Y, Heward CB, Roberts LJ 2nd, Harman SM. Tart cherry juice decreases oxidative stress in healthy older men and women. J Nutr. 2009 Oct;139(10):1896-900. doi: 10.3945/jn.109.111716. Epub 2009 Aug 19.
PMID: 19692530DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Tinna Traustadottir, Ph.D.
Kronos Longevity Research Institute
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- PREVENTION
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
February 17, 2009
First Posted
February 19, 2009
Study Start
October 1, 2007
Primary Completion
April 1, 2008
Study Completion
April 1, 2008
Last Updated
February 19, 2009
Record last verified: 2009-02