Comparison of Acute Tart Cherry Supplement Formulation and Dose on Inflammation and Oxidative Capacity
1 other identifier
interventional
48
0 countries
N/A
Brief Summary
A comparison of acute tart cherry formations (juice vs. powdered) and doses (single vs. twice daily) on inflammation and oxidative capacity.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Sep 2015
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 15, 2015
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 30, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
May 30, 2017
CompletedFirst Submitted
Initial submission to the registry
July 27, 2020
CompletedFirst Posted
Study publicly available on registry
August 4, 2020
CompletedAugust 4, 2020
July 1, 2020
1.3 years
July 27, 2020
July 29, 2020
Conditions
Outcome Measures
Primary Outcomes (3)
Change in c-reactive protein
c-reactive protein (mg/L) measured via assay
1 hour, 2 hours, 8 hours, 24 hours, and 48 hours post ingestion
Change in uric acid
uric acid (mg/dL) measured via assay
1 hour, 2 hours, 8 hours, 24 hours, and 48 hours post ingestion
Change in oxidative capacity
oxygen radical absorbance capacity (uM Trolox equivalents) measured via assay
1 hour, 2 hours, 8 hours, 24 hours, and 48 hours post ingestion
Study Arms (6)
single dose tart cherry capsule
EXPERIMENTALsingle dose tart cherry capsule
double dose tart cherry capsule
EXPERIMENTALdouble dose tart cherry capsule
single dose tart cherry juice
EXPERIMENTALsingle dose tart cherry juice
double dose tart cherry juice
EXPERIMENTALdouble dose tart cherry juice
single placebo capsule
EXPERIMENTALsingle placebo capsule
single placebo juice
EXPERIMENTALsingle placebo juice
Interventions
Either tart cherry juice or freeze dried powdered tart cherry in capsule was given
either cornstarch capsule or kool-aid
Eligibility Criteria
You may qualify if:
- free of cardiovascular, metabolic and inflammatory conditions
- non-smokers
- no known allergy to cherries or cherry juice
- not be taking food supplements (turmeric/curcumin, cherry products, greens, etc.).
You may not qualify if:
- quit smoking less than one year ago.
- currently being treated for arthritis or an inflammatory condition.
- currently being treated for uncontrolled cardiovascular disease, high blood pressure, diabetes, fibromyalgia, or irritable bowel syndrome.
- pregnant.
- regularly consume cherries or are allergic to cherries or dairy.
- currently use anti-inflammatory medications,
- have used corticosteroids in the last two months.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Ohio Universitylead
- Marywood Universitycollaborator
Related Publications (1)
Hillman AR, Uhranowsky K. Acute Ingestion of Montmorency Tart Cherry Reduces Serum Uric Acid but Has no Impact on High Sensitivity C-Reactive Protein or Oxidative Capacity. Plant Foods Hum Nutr. 2021 Mar;76(1):83-89. doi: 10.1007/s11130-021-00879-7. Epub 2021 Jan 27.
PMID: 33506357DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant Professor
Study Record Dates
First Submitted
July 27, 2020
First Posted
August 4, 2020
Study Start
September 15, 2015
Primary Completion
December 30, 2016
Study Completion
May 30, 2017
Last Updated
August 4, 2020
Record last verified: 2020-07
Data Sharing
- IPD Sharing
- Will not share
upon request