Feedbacks' Influence on Decision Making Processes

NCT02816632 | Completed

• 2 other identifiers: 69HCL15_02212015-A00623-46
• Study Type: interventional
• Target: 76
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this research is to identify and probe the neural networks involved in feedback processing. It aims at translating this knowledge to clinical populations in which this network is disrupted or compromised. It includes two studies: 1) with fMRI in healthy subjects to identify the neural bases of feedback processing on decision making using different types of feedback (neutral, social and monetary) presented either infra- or supra-laminary and 2) probing the role of one structure, the anterior cingulate cortex, using Galvanic Vestibular Stimulation (GVS) in healthy subjects. The interventional part consists in the administration of Galvanic Vestibular Stimulation (GVS), which by means of small intensity currents activates the vestibular organs and subsequently vestibular-related brain areas. GVS will be delivered to healthy participants engaged in behavioural tasks requiring the processing of feedbacks of different nature (e.g. social or monetary feedbacks)

Conditions

Healthy Volunteers

Keywords

functional Magnetic Resonance Imaging; Galvanic Vestibular Stimulation; Feedback Processing; Reward, Social, Vestibular System; Cingulate Cortex; Decision-making

Outcome Measures

Primary Outcomes (2)

• Behavioral performance (Accuracy)

  The proportion of correct responses, automatically computed by professional programs (e.g. Presentation) running on standard Personal Computers depending on different contexts (e.g. different feedback: neutral, social and monetary).

  up to 4 days

• Behavioral performance (Reaction times)

  The proportion of reaction times provided, automatically computed by professional programs (e.g. Presentation) running on standard Personal Computers depending on different contexts (e.g. different feedback: neutral, social and monetary).

  up to 4 days

Secondary Outcomes (1)

• Neural activity (BOLD signal measured using fMRI) as a function of the nature of the feedback.

  up to 4 days

Study Arms (1)

healthy volunteers

EXPERIMENTAL

Other: mRI; Other: Effect of Galvanic Vestibular Stimulation on decision making processes

Interventions

mRI OTHER

Neural bases of feedbacks' influence on decision making processes

healthy volunteers

Effect of Galvanic Vestibular Stimulation on decision making processes OTHER

Galvanic Vestibular Stimulation (GVS) stimulates the vestibular system through low intensity electric currents applied at the basis of the VIII cranial nerve, upon the mastoid processes. In the Right-Anodal condition the positive electric charge is applied through electrodes placed upon the right mastoid and it mainly activates structures within the left brain hemisphere. In the Left-Anodal condition the positive electric charge is applied through electrodes placed upon the left mastoid and it mainly activates structures within the right brain hemisphere. In the SHAM condition, low intensity electric currents are applied 5 cm below the mastoid processes. This condition does not activate the vestibular system and serves as a control condition to account for unspecific activating effects of all electric stimulations (e.g., arousal, discomfort). The three conditions will be applied in three different sessions (i.e. days) in randomized order.

healthy volunteers

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Benefit of social health security
• Normal or corrected-to-normal vision

You may not qualify if:

• Anamnesis of neurological of psychiatric illness
• Pregnancy or breastfeeding
• Administrative measures restricting legal rights
• Epilepsy (including familiarity), migraines, chronic headaches
• presence of pacemakers, cochlear implants, surgical clips, or any metallic component fixed in participants' body
• Current treatment with psychotropic drugs
• Alcohol assumption during the last 24 hours
• Sleep deprivation
• Recent participation to other brain stimulation studies (\< 1 week)

Sponsors & Collaborators

• Hospices Civils de Lyon: lead

Study Sites (1)

Unité de Neuro-Ophtalmologie Hôpital Neurologique - HOSPICES CIVILS DE LYON

Bron, 69500, France

Location

Related Publications (2)

• Blini E, Tilikete C, Farne A, Hadj-Bouziane F. Probing the role of the vestibular system in motivation and reward-based attention. Cortex. 2018 Jun;103:82-99. doi: 10.1016/j.cortex.2018.02.009. Epub 2018 Feb 27.

  PMID: 29574253 BACKGROUND

• Blini E, Tilikete C, Chelazzi L, Farne A, Hadj-Bouziane F. The role of the vestibular system in value attribution to positive and negative reinforcers. Cortex. 2020 Dec;133:215-235. doi: 10.1016/j.cortex.2020.09.004. Epub 2020 Oct 2.

  PMID: 33130427 BACKGROUND

Study Officials

• Caroline TILIKETE, MD

  Unité de Neuro-Ophtalmologie Hôpital Neurologique - HOSPICES CIVILS DE LYON

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 20, 2016
• First Posted: June 28, 2016
• Study Start: March 30, 2017
• Primary Completion: September 18, 2019
• Study Completion: September 18, 2019
• Last Updated: September 3, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)