Changes in Perception and Cognition During a Meditation Retreat

NCT04449913 | Completed

• 2 other identifiers: 69HCL20_00032020-A00669-30
• Study Type: interventional
• Target: 58
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims at assessing neuro-behavioral changes occuring during an intensive ten days meditation retreat. The investigator will study changes in tactile, auditory and pain perceptions as well as changes in cognitive and affective mental contents and their neural markers, as measured by self-reports, EEG event-related potentials, and functional connectivity of resting state fMRI. He will recruit healthy participants with a prior meditation experience. They will be randomly assigned to two groups, one active group who will undergo measurements just before, during and 3 weeks after the retreat. The other group will serve of control for task habituation, control participants will undergo the same measurements, equally spaced in time, but before the retreat. The main hypothesis is that meditation training strengthens meta-awareness, attention capacities resulting in enhanced bodily- and self-awareness during sensory perception and emotion regulation during pain.

Conditions

Healthy Volunteers

Keywords

Meditation; Emotional Regulation; Metacognitive Awareness; Attention; Mindfulness; Pain; Predictive Coding

Outcome Measures

Primary Outcomes (9)

• changes in matched forces (Newtons) during a force-matching task.

  Bodily awareness following meditation training could impact the attenuation of real tactile sensations during self-generated touch. Measurement of pressure force will be done through a force-matching paradigm.

  1 or 2 days before the start of the retreat

• changes in matched forces (Newtons) during a force-matching task.

  Bodily awareness following meditation training could impact the attenuation of real tactile sensations during self-generated touch. Measurement of pressure force will be done through a force-matching paradigm.

  7 days later

• changes in matched forces (Newtons) during a force-matching task.

  Bodily awareness following meditation training could impact the attenuation of real tactile sensations during self-generated touch. Measurement of pressure force will be done through a force-matching paradigm.

  at least 3 weeks after the end of the retreat

• changes in EEG an auditory evoked response called the mismatch negativity (microVolt)

  Moment-to-moment monitoring following meditation training could downregulate the automatic formation of perceptual habits. Measurement of auditory evoked potentials will be done through Biosemi 64 electrodes EEG net during an auditory oddball task.

  1 or 2 days before the start of the retreat

• changes in EEG an auditory evoked response called the mismatch negativity (microVolt)

  Moment-to-moment monitoring following meditation training could downregulate the automatic formation of perceptual habits. Measurement of auditory evoked potentials will be done through Biosemi 64 electrodes EEG net during an auditory oddball task.

  7 days later

• changes in EEG an auditory evoked response called the mismatch negativity (microVolt)

  Moment-to-moment monitoring following meditation training could downregulate the automatic formation of perceptual habits. Measurement of auditory evoked potentials will be done through Biosemi 64 electrodes EEG net during an auditory oddball task.

  at least 3 weeks after the end of the retreat

• changes in EEG pain-related evoked responses (microVolt)

  Moment-to-moment monitoring and emotion regulation following meditation training could downregulate pain catastrophizing. Measurement pain-related evoked potentials will be done through Biosemi 64 electrodes EEG net during a pain characterization task.

  1 or 2 days before the start of the retreat

• changes in EEG pain-related evoked responses (microVolt)

  Moment-to-moment monitoring and emotion regulation following meditation training could downregulate pain catastrophizing. Measurement pain-related evoked potentials will be done through Biosemi 64 electrodes EEG net during a pain characterization task.

  7 days later

• changes in EEG pain-related evoked responses (microVolt)

  Moment-to-moment monitoring and emotion regulation following meditation training could downregulate pain catastrophizing. Measurement pain-related evoked potentials will be done through Biosemi 64 electrodes EEG net during a pain characterization task.

  at least 3 weeks after the end of the retreat

Secondary Outcomes (16)

• Changes in perceived pain intensity during a pain paradigm

  1 or 2 days before the start of the retreat

• Changes in perceived pain intensity during a pain paradigm

  7 days later

• Changes in perceived pain intensity during a pain paradigm

  at least 3 weeks after the end of the retreat

• Changes in perceived pain unpleasantness during a pain paradigm.

  at least 3 weeks after the end of the retreat

• Changes in perceived pain unpleasantness during a pain paradigm.

  1 or 2 days before the start of the retreat

Study Arms (2)

Active group

EXPERIMENTAL

10 days intensive meditation retreat

Behavioral: 10 days intensive meditation retreat

Control group

OTHER

Waiting for a 10 days intensive meditation retreat

Behavioral: Waiting for a 10 days intensive meditation retreat

Interventions

10 days intensive meditation retreat BEHAVIORAL

The intervention consists in a 10 days contemplative retreat, with 6 to 8 hours of sitting and walking meditation per day, and 1 or 2 hours of meditation teachings. The meditation practice will mainly train in mindfulness practice. Mindfulness meditation intends to train attention to detect and regulate afflictive cognitive and emotional patterns. Mindfulness practice requires skills involved in openness to experience, in monitoring the focus of attention and in detecting distraction, disengaging attention from the source of distraction, and flexibly (re)directing and engaging attention to the intended object. A brief introduction to loving-kindness and compassion meditation will also be present throughout the retreat.

Active group

Waiting for a 10 days intensive meditation retreat BEHAVIORAL

At the time of measure, participants in this group are waiting to participate to the same meditation retreat as the active group. They may perform their own daily meditation practices as usual.

Control group

Eligibility Criteria

• Age: 18 Years - 67 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age between 18 and 67
• Regular meditation practice (at least 20 minutes 3 times a week) arising from a formal teaching (buddhist tradition, MBSR, mindfulness) for at least one year.
• Having taken part to at least one intensive retreat (more than six hours of sitting meditation a day, during at least two days) in the past.
• Affiliated to french social security
• Motivated to take part in the study
• Having signed an informed consent
• Normal or corrected vision
• Sufficient mastering of French to be able to understand correctly written and auditory instructions

You may not qualify if:

• neurological or psychiatric antecedents
• chronical pain or any other medical condition giving rise to acute pain or sensitivity to pain.
• Motor or sensory deficit in the hands
• severe auditory loss
• regularly taking medical drugs acting on the central nervous system
• regularly taking opioids or antidepressant drugs
• alcohol consumption above the safety threshold recognized by the French healthy agency (10 drinks a week, 2 drinks a day, 5 drinks for special occasions)
• drugs consumption (except tabacco) qualified as addictive according to medical criteria (https://www.drogues.gouv.fr/comprendre/l-essentiel-sur-les-addictions/qu-est-ce-qu-une-addiction)
• alcohol or drug consumption the day before or the day of experiment and during the full duration of the retreat
• being pregnant, breastfeading or having given birth less than 6 months ago
• Will be excluded from the fMRI task only, participants presenting contraindication to a MRI scan : being claustrophobic, body mass index over 30, people, having a pacemaker or an insuline pump, metallic prothesis, intracranial clip, neurosensory stimulator, in-body defibrillator, cochlear implants, ocular or brain feromagnetic bodies close to nervous structures, neurosurgery stunts, dental brace.

Sponsors & Collaborators

• Hospices Civils de Lyon: lead

Study Sites (1)

Centre de Recherche en Neuroscience de Lyon

Bron, 69500, France

Location

MeSH Terms

Conditions

Emotional Regulation; Pain

Condition Hierarchy (Ancestors)

Self-Control; Social Behavior; Behavior; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Antoine LUTZ, PhD

  Centre de recherche de Neurosciences de Lyon (CRNL)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 24, 2020
• First Posted: June 29, 2020
• Study Start: October 2, 2020
• Primary Completion: April 10, 2021
• Study Completion: April 10, 2021
• Last Updated: October 27, 2021

Record last verified: 2021-10

Locations

FR (1)