The Effect of Dietary Lauric Acid on the Production of the LRH-1 Ligand, Dilauroylphosphatidylcholine

NCT03481608 | Completed

• 1 other identifier: 1802007735
• Study Type: interventional
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

A phosphatidylcholine species enriched with lauric acid at both the sn-1 and sn-2 positions, dilauroylphosphatidylcholine (DLPC), was recently identified as a ligand for the nuclear receptor, liver receptor homolog-1 (LRH-1). To date, DLPC has not been reported in vitro or in vivo, and has yet to be catalogued in the human metabolomics database. This intervention trial aims to determine the impact of consumption of dietary lauric acid, in the form of coconut oil (49% lauric acid), can facilitate the production of DLPC in humans.

Conditions

Diet Modification

Keywords

fatty acid; nutrition; metabolism; lauric acid; dilauroylphosphatidylcholine; lrh-1

Outcome Measures

Primary Outcomes (1)

• DLPC in Postprandial Serum

  The presence of DLPC in postprandial serum will be measured using Liquid Chromatography Tandem Mass Spectrometry

  6 hours postprandial

Secondary Outcomes (1)

• Serum Total Bile Acids

  6 hours postprandial

Study Arms (2)

Olive Oil Shake

ACTIVE COMPARATOR

Intervention: No Lauric Acid A breakfast shake made from a complete meal shake will be prepared with water and supplemented with 2 tablespoons of olive oil.

Other: No Lauric acid (olive oil)

Coconut Oil Shake

EXPERIMENTAL

Intervention: Lauric Acid A breakfast shake made from a complete meal shake will be prepared with water and supplemented with 2 tablespoons of coconut oil.

Other: Lauric acid (coconut oil)

Interventions

Lauric acid (coconut oil) OTHER

A breakfast shake made from a complete meal shake will be prepared with water and supplemented with 2 tablespoons of coconut oil.

Coconut Oil Shake

No Lauric acid (olive oil) OTHER

A breakfast shake made from a complete meal shake will be prepared with water and supplemented with 2 tablespoons of olive oil.

Olive Oil Shake

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Willingness to comply with the study protocol
• Ability to overnight fast
• Willingness to donate blood
• 'generally healthy'

You may not qualify if:

• self-reported regular consumption of tropical oils or supplements containing lauric acid
• self-reported food allergies to shake ingredients
• medical conditions where blood draws or fasting may be contraindicated
• major gastrointestinal conditions, such as inflammatory bowel disease

Sponsors & Collaborators

• Cornell University: lead

Study Sites (1)

Human Metabolic Research Unit, Cornell University

Ithaca, New York, 14853, United States

Location

MeSH Terms

Interventions

lauric acid; Coconut Oil; Olive Oil

Intervention Hierarchy (Ancestors)

Dietary Fats; Fats; Lipids; Plant Oils; Oils; Dietary Fats, Unsaturated; Fats, Unsaturated; Food; Diet, Food, and Nutrition; Physiological Phenomena; Food and Beverages

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: Participants will be blinded to the intervention oil (single-blind).
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Acute feeding study. Participants will arrive at our Human Metabolic Research Unit on 2 separate occasions. Participants will be randomized to consume 1 of 2 shake on each occasion. Shakes will be prepared with 2 tablespoons of either control (olive) or intervention (coconut) oils.

Study Record Dates

• First Submitted: March 8, 2018
• First Posted: March 29, 2018
• Study Start: March 19, 2018
• Primary Completion: April 12, 2018
• Study Completion: April 22, 2018
• Last Updated: March 22, 2022

Record last verified: 2022-03

Locations

US (1)