Which Factors Influence the Duration and the Success of Mechanical Thrombectomy During the Acute Phase of Cerebral Infarction?

NCT03451903 | Completed

• 1 other identifier: P/2017/348
• Study Type: observational
• Target: 106
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study aims to identify factors influencing the time span and success of reperfusion after a mechanical thrombectomy in the acute phase of cerebral infarction, and in particular the effect of intra-venous thrombolysis.

Conditions

Acute Stroke

Keywords

stroke; thrombectomy; procedure time; revascularisation; thrombolytic therapy

Outcome Measures

Primary Outcomes (1)

• Duration of the procedure

  It is the period of time between when the artery is punctured and when the first image from the first cerebral angiographic test is acquired after revascularisation, which is used to calculate the rate of revascularisation.

  From the beginning of mechanical thrombectomy to the end of the procedure.

Study Arms (2)

Mechanical thrombectomy group

Patients with acute stroke treated by mechanical thrombectomy.

Procedure: Mechanical thrombectomy

Combined procedure group

Patients with acute stroke treated by intravenous thrombolysis (with actilyse) and mechanical thrombectomy.

Drug: Actilyse; Procedure: Mechanical thrombectomy

Interventions

Actilyse DRUG

Actilyse is the intra-venous agent used for intra-venous thrombolysis in the acute phase of cerebral infarction.

Also known as: rtPA

Combined procedure group

Mechanical thrombectomy PROCEDURE

Mechanical thrombectomy is an endovascular procedure by which an arterial clot is retrieved, in order to reperfuse the brain.

Combined procedure group; Mechanical thrombectomy group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who had undergone an arteriography for cerebral infarction prior to mechanical thrombectomy at CHRU Besançon. Data are prospectively collected in the Franche-Comté Stroke Registry.

You may qualify if:

• acute phase of cerebral infarction
• all patients who had undergone an arteriography for cerebral infarction prior to mechanical thrombectomy at CHRU Besançon
• from 1st January 2015 to 31st December 2016

You may not qualify if:

• Patients whose procedures were interrupted (puncture failure, catheterisation of the common or internal carotid artery failure)
• Patients whose arteries were recanalised during the diagnostic arteriography

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Besancon: lead

MeSH Terms

Conditions

Stroke

Interventions

Tissue Plasminogen Activator

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Serine Endopeptidases; Endopeptidases; Peptide Hydrolases; Hydrolases; Enzymes; Enzymes and Coenzymes; Serine Proteases; Plasminogen Activators; Blood Coagulation Factors; Blood Proteins; Proteins; Amino Acids, Peptides, and Proteins; Biological Factors

Study Officials

• Louise Bonnet, MD

  J Minjoz Besancon university Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 26, 2018
• First Posted: March 2, 2018
• Study Start: January 1, 2015
• Primary Completion: December 31, 2016
• Study Completion: February 1, 2018
• Last Updated: March 29, 2018

Record last verified: 2018-02

Data Sharing

• IPD Sharing: Will not share