Effect of Endurance and Endurance-Strength Training on Inflammatory Markers in Women With Abdominal Obesity

NCT03444207 | Completed

• 1 other identifier: 1077/12; 753/13
• Study Type: interventional
• Target: 38
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study was to compare the effects of three months' endurance training and three months' endurance-strength training on inflammatory markers in women with abdominal obesity.

Conditions

Obesity

Keywords

obesity; inflammation; C-reactive protein; training; tumor necrosis factor alfa

Outcome Measures

Primary Outcomes (2)

• C-reactive protein (CRP) at baseline

  Serum concentration of C-reactive protein at baseline

  At baseline

• CRP after three months of physical training

  Serum concentration of C-reactive protein after three months of physical training

  after three months of physical training

Secondary Outcomes (14)

• tumor necrosis factor alpha (TNFα) at baseline

  at baseline

• TNFα after three months of physical training

  after three months of physical training

• soluble receptor 2 of TNF alpha (sTNF R2) at baseline

  At baseline

• sTNF R2 after three months of physical training

  after three months of physical training

• interleukin 6 (IL-6) at baseline

  At baseline

Study Arms (2)

Group A

EXPERIMENTAL

Endurance training

Behavioral: Endurance training

Group B

EXPERIMENTAL

Endurance-strength training

Behavioral: Endurance-strength training

Interventions

Endurance training BEHAVIORAL

The women in group A underwent endurance exercise on cycle ergometers (Schwinn Evolution, Schwinn Bicycle Company, Boulder, Colorado, USA). Exercise sessions consisted of a five-minute warm-up (stretching exercise) at low intensity (50%-60% of maximum heart rate), a 45-minute exercise (at 50%-80% of maximum heart rate), five minutes of cycling without a load, and five minutes of closing stretching and breathing exercise of low intensity.

Group A

Endurance-strength training BEHAVIORAL

Group B performed endurance-strength exercise consisting of a five-minute warm-up (stretching exercises) of low intensity (50%-60% of maximum heart rate), a strength component, an endurance component, 5 minutes cycling without a load, and a 5 minutes closing stretching and breathing exercise of low intensity. The 20-minute-long strength component was performed using a neck barbell and a gymnastic ball. Directly after the strength exercise, the women took part in a 25-minute endurance exercise on cycle ergometers (Schwinn Evolution, Schwinn Bicycle Company, Boulder, Colorado, USA) at 50%-80% of maximum heart rate.

Group B

Eligibility Criteria

• Age: 18 Years - 65 Years
• Gender Eligibility Details: Self-representation of gender identity.
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• informed written consent;
• simple obesity;
• age from 18 to 65 years;
• body fat content, assessed by electrical bioimpedance, equal to or more than 33%;
• waist circumference more than 80 cm;
• stable body weight in the one month prior to the trial.

You may not qualify if:

• secondary form of excess body mass
• secondary form of arterial hypertension
• mean systolic blood pressure \> 140 mmHg and/or mean diastolic blood pressure \> 90 mmHg;
• diabetes;
• ischemic heart disease;
• stroke;
• heart failure;
• history of malignancy;
• clinically significant heart arrhythmias;
• a history of use of any dietary supplement;
• serious liver or kidney damage;
• abnormal thyroid gland function;
• clinically significant inflammation, connective tissue disease, or arthritis;
• nicotine, alcohol, or narcotic abuse;
• infection;

Sponsors & Collaborators

• Poznan University of Medical Sciences: lead

Study Sites (1)

Department of Education and Obesity Treatment and Metabolic Disorders; Poznan University of Medical Sciences

Poznan, 60-569, Poland

Location

Related Publications (1)

• Jamka M, Piotrowska-Brudnicka SE, Karolkiewicz J, Skrypnik D, Bogdanski P, Cielecka-Piontek J, Sultanova G, Walkowiak J, Madry E. The Effect of Endurance and Endurance-Strength Training on Bone Health and Body Composition in Centrally Obese Women-A Randomised Pilot Trial. Healthcare (Basel). 2022 Apr 28;10(5):821. doi: 10.3390/healthcare10050821.

  PMID: 35627958 DERIVED

MeSH Terms

Conditions

Obesity; Inflammation

Interventions

Endurance Training

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Pathologic Processes

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Pawel Bogdanski, Prof.

  Department of Education and Obesity Treatment and Metabolic Disorders; Poznan University of Medical Sciences

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: The study was designed as a prospective randomized trial.

Study Record Dates

• First Submitted: February 13, 2018
• First Posted: February 23, 2018
• Study Start: December 6, 2012
• Primary Completion: December 1, 2017
• Study Completion: December 30, 2017
• Last Updated: February 23, 2018

Record last verified: 2018-02

Locations

PL (1)