Tissue-specific Effects of Insufficient Sleep

NCT03437681 | Unknown

• 1 other identifier: 17-0533
• Study Type: interventional
• Target: 18
• Locations: 1 country
• Sites: 1

Brief Summary

This study plans to learn more about how sleep loss impacts the way the body responds to sugar. This work will have important implications for development of treatments and countermeasures for people who are not able to get enough sleep for various reasons.

Conditions

Healthy

Keywords

Sleep; Blood Sugar

Outcome Measures

Primary Outcomes (1)

• Change in insulin sensitivity

  Insulin sensitivity measured by hyperinsulinemic euglycemic clamp.

  One week

Secondary Outcomes (5)

• Changes in macrovascular function

  One week

• Changes in microvascular function

  One week

• Changes in cognitive abilities

  One week

• Changes in circadian rhythms

  One week

• Changes in metabolic tissue function

  One week

Study Arms (1)

Insufficient sleep

EXPERIMENTAL

Each participant will receive 4 nights of insufficient sleep.

Behavioral: Insufficient sleep

Interventions

Insufficient sleep BEHAVIORAL

Four days of insufficient sleep

Insufficient sleep

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy, lean participants.
• No regular physical activity (\<20 minutes/day). No exercise will be allowed for 3 days prior to study start.
• Habitual sleep duration between 7-9.25h. Subjects must also be willing and able to keep a 9h time-in-bed schedule for 1 week prior to study admission.
• Potential subjects must have lived at Denver altitude or higher for at least 3 months to inpatient study.

You may not qualify if:

• Current or history of any clinically significant medical, psychiatric, or sleep disorder.
• Use or history of any drugs, medications, supplements, caffeine, and alcohol.
• Current or history of shiftwork in six months prior to laboratory study.
• Travel more than one time zone in three weeks prior to laboratory study.
• Blood donation in the 30 days prior to inpatient study.

Sponsors & Collaborators

• University of Colorado, Denver: lead

Study Sites (1)

University of Colorado Anschutz Medical Campus

Aurora, Colorado, 80045, United States

Location

Related Links

• Full list of publications

Study Officials

• Josiane L. Broussard, PhD

  University of Colorado, Boulder

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: The project is a within-subject consecutive design examining 18 healthy individuals after baseline and after 4 nights of insufficient sleep.

Study Record Dates

• First Submitted: February 6, 2018
• First Posted: February 19, 2018
• Study Start: February 12, 2018
• Primary Completion: June 30, 2024
• Study Completion: December 30, 2024
• Last Updated: November 30, 2023

Record last verified: 2023-11

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)