The Acute Effects of Food Structure on Post Prandial Glucose and Subsequent Metabolic Responses

NCT03424187 | Completed Results

• 1 other identifier: 15HH3069
• Study Type: interventional
• Target: 15
• Locations: 0 countries
• Sites: N/A

Brief Summary

Aims: To investigate the effects of different food structures on glucose concentrations and subsequent metabolic responses including insulin,GIP, GLP-1 DESIGN: A randomised, controlled, clinical trial.

Conditions

Obesity

Outcome Measures

Primary Outcomes (2)

• Post-prandial Glucose Concentrations

  Blood glucose concentrations were assessed for each participant after each test meal: whole chickpea hummus, Flour chickpea hummus, and Intact cell chickpea hummus. Blood samples were collected before the introduction of the test meal and then at 15 minutes, 30 min, 60, 90, 120, and 180 minutes after the consumption of the test meal. Data were not collected for intact cell chickpea hummus

  before the consumption of the test meal and then 15 min, 30, 60,90, 120, 180 minutes after the consumption of the test meal.

• Post-prandial Blood Insulin Concentrations

  Blood glucose concentrations were assessed for each participant after each test meal: whole chickpea hummus, Flour chickpea hummus, and Intact cell chickpea hummus. Blood samples were collected before the introduction of the test meal and then at 15 minutes, 30 min, 60, 90, 120, and 180 minutes after the consumption of the test meal.

  before the consumption of the test meal and then 15, 30, 60, 90, 120, and 180 minutes post consumption of test meal.

Secondary Outcomes (3)

• Post-prandial Gut Hormone Gastric Inhibitory Polypeptide (GIP)

  before the consumption of the test meal at 0 min and then post test meal at 15, 30,60 ,90,120 and 180 minutes.

• Post-prandial Gut Hormone Glucagon-like Peptide 1 (GLP-1)

  baseline before the consumption of the test meal, and then 15,30,60,90,120,180 min after the consumption of the test meal.

• Energy Intake at a Meal Given in Excess

  post consumption of the test meal at 120 minutes

Study Arms (3)

whole chickpea

EXPERIMENTAL

a test meal containing 26g available carbohydrates from chickpea (full structure)

Dietary Supplement: chickpea

flour chickpea

EXPERIMENTAL

a test meal containing 26g available carbohydrates from flour chickpea (destroyed structure)

Dietary Supplement: chickpea

intact cell chickpea

EXPERIMENTAL

a test meal containing 26g available carbohydrates from intact cell chickpea flour (full structure)

Dietary Supplement: chickpea

Interventions

chickpea DIETARY_SUPPLEMENT

all three meals are isocaloric but different in the chickpea structure( physical form): • Whole chickpea, flour chickpea, intact cell flour chickpea

flour chickpea; intact cell chickpea; whole chickpea

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Gender: male and female
• Age ≥ 18 years ≤ 65 years
• Normal weight as classified by BMI 20-29.9 kg/m2
• Willingness and ability to understand, participate and to comply with the study requirements
• Willingness and ability to give written informed consent

You may not qualify if:

• Has thyroid defects
• Under hormone or steroids therapy
• Is pregnant or lactating (female)
• Had given birth within the past year (female)
• Is taking drugs that could affect appetite or plasma glucose levels.
• Is taking natural remedies that modulate appetite or plasma glucose levels.
• Has excessive alcohol intake
• Had blood donation within 12wks prior to start date
• Psychiatric illness
• Smokers
• History of any disease with unknown outcome
• Has diabetes
• Has nut allergy

Sponsors & Collaborators

• Imperial College London: lead

Related Publications (1)

• Alshaalan RA, Charalambides MN, Edwards CH, Ellis PR, Alrabeah SH, Frost GS. Impact of chickpea hummus on postprandial blood glucose, insulin and gut hormones in healthy humans combined with mechanistic studies of food structure, rheology and digestion kinetics. Food Res Int. 2024 Jul;188:114517. doi: 10.1016/j.foodres.2024.114517. Epub 2024 May 10.

  PMID: 38823849 DERIVED

MeSH Terms

Conditions

Obesity

Interventions

cicerin protein, Cicer arietinum

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Results Point of Contact

• Title: Gary Frost
• Organization: Imperial College London

g.frost@imperial.ac.uk

+44 20 7594 0959

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 1, 2017
• First Posted: February 6, 2018
• Study Start: July 1, 2016
• Primary Completion: May 1, 2017
• Study Completion: July 1, 2018
• Last Updated: April 2, 2021
• Results First Posted: April 2, 2021

Record last verified: 2021-03