Crave Crush Neuroimaging Study
Effects of Gymnemic Acids Lozenge on Reward Region Response to Receipt and Anticipated Receipt of High-Sugar Food, High-Sugar Food Pictures, and Ad Lib Candy Intake
1 other identifier
interventional
40
0 countries
N/A
Brief Summary
The purpose of the research is to test whether a gymnemic acids (GA) lozenge will reduce reward region response to intake of high-sugar food and ad lib candy intake and whether the GA lozenge reduced reward region response to anticipated intake of high-sugar food and high-sugar food pictures relative to a placebo lozenge.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable obesity
Started Dec 2015
Shorter than P25 for not_applicable obesity
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
December 1, 2015
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2016
CompletedFirst Submitted
Initial submission to the registry
October 26, 2016
CompletedFirst Posted
Study publicly available on registry
October 31, 2016
CompletedJuly 19, 2018
July 1, 2018
6 months
October 26, 2016
July 17, 2018
Conditions
Outcome Measures
Primary Outcomes (1)
fMRI responses to high-sugar food tastes and food cues
Blood oxygen dependent signal (BOLD) response in exposure to intake of high-sugar food and food cues will be measured during a fMRI scan to test whether the GA lozenge produces greater reductions in activity in reward-related brain regions relative to a placebo lozenge.
13 minutes
Secondary Outcomes (1)
candy consumption
15 minutes
Study Arms (2)
Crave Crush
EXPERIMENTALCrave Crush is a plant-based tablet that alters taste perception by affecting sweet taste receptors on the tongue.
Placebo
PLACEBO COMPARATORThe placebo tablet is comparable in taste and is comprised primarily of sorbitol.
Interventions
Crave Crush is a dietary supplement that affects sweet taste receptors on the tongue.
The placebo tablet is comparable in taste and is comprised primarily of sorbitol.
Eligibility Criteria
You may qualify if:
- Between 18 and 50 years old
- report having a sweet tooth
- report desire to lose weight
- Body Mass Index between 18 and 40
You may not qualify if:
- major psychiatric disorders
- serious health problems (e.g., diabetes)
- habitual use of psychoactive drugs or medications
- contraindications for MRI scanning (e.g., ferromagnetic braces)
- gluten or lactose intolerance
- a vegan diet.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Eric Stice, Ph.D.
Oregon Research Behavioral Intervention Strategies
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- BASIC SCIENCE
- Intervention Model
- CROSSOVER
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
October 26, 2016
First Posted
October 31, 2016
Study Start
December 1, 2015
Primary Completion
June 1, 2016
Study Completion
June 1, 2016
Last Updated
July 19, 2018
Record last verified: 2018-07
Data Sharing
- IPD Sharing
- Will not share