Obesity and Adipose Tissue Inflammation in Pregnant Mothers

NCT03412981 | Completed

• 1 other identifier: 2004215 Pregnant Moms
• Study Type: observational
• Target: 27
• Locations: 1 country
• Sites: 2

Brief Summary

To date very little research has been conducted on pregnant mothers. Research shows that mothers with obesity and gestational diabetes have children who have a higher risk of later developing obesity and diabetes compared to children born to non-obese mothers but the mechanisms are not known. The maternal environment may place these babies at greater risk and it is possible that fat tissue (adipose tissue) releases many chemicals (adipokines and inflammatory cytokines) which may have an impact on the baby. Mothers who have greater amounts of adipose tissue most likely release these adipokines into the baby and it may affect the baby's body composition and/or health. This project will establish if there is a relationship between obesity and adipose tissue inflammation in pregnant mothers, and if there is a link between inflammation and the child's body composition. We will recruit mothers with low risk pregnancies already schedule for a C section at about 36 wk. We will do initial testing at 36 wk, adipose tissue collection at delivery, and conduct post testing at 1 month postpartum on the mother and the baby.

Conditions

Healthy

Outcome Measures

Primary Outcomes (1)

• TNFa

  TNFa, IL-6, IL-4, IL-13

  at delivery

Secondary Outcomes (5)

• body fat

  after delivery

• IL-6

  at delivery

• IL-4

  at delivery

• IL-13

  at delivery

• baby weight

  at birth

Interventions

pregnant mothers OTHER

we will be collecting data on a cohort of pregnant mothers

Eligibility Criteria

• Age: 21 Years - 40 Years
• Gender Eligibility Details: Eligibility is based on being able to get pregnant
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Recruiting from women who will deliver their babies at Women and Children's hospital in Columbia, MO

You may qualify if:

• Mothers who have low risk pregnancies (21-40 years) and are already scheduled to have a C-section. BMI ≤ 40 kg/m2

You may not qualify if:

• We will exclude emergency C-sections
• Subjects will have had a screening ultrasound that demonstrated the absence of congenital anomalies as part of routine prenatal care
• Mothers with high risk pregnancy
• BMI \> 40 kg/m2

Sponsors & Collaborators

• University of Missouri-Columbia: lead

Study Sites (2)

University of Misouri

Columbia, Missouri, 65211, United States

Location

University of Missouri

Columbia, Missouri, 65211, United States

Location

Study Officials

• Jill Kanaley, PhD

  University of Missouri-Columbia

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: professor

Study Record Dates

• First Submitted: January 20, 2018
• First Posted: January 29, 2018
• Study Start: December 1, 2017
• Primary Completion: March 31, 2020
• Study Completion: October 31, 2020
• Last Updated: November 3, 2020

Record last verified: 2020-10

Data Sharing

• IPD Sharing: Will not share

Locations

US (2)