Low Intensity Physical Activity During Sitting on Glycemic Control and Vascular Function in Obese Individuals

NCT03419754 | Completed

• 1 other identifier: Fidget
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Prolonged sitting is a common behavior in contemporary humans. In epidemiological studies, increased sitting time has been associated with increased risk for cardiovascular disease and all-cause mortality. Recent research has also shown that interrupting sitting time with standing prevents the poorer glycemic control. However, studies are lacking which evaluate the impact of low intensity physical activity during prolonged sitting on vascular function. Whether low intensity physical activity can increase blood flow substantially and prevent impairment in vascular function and glycemic control is unknown. The purpose of the present study is to evaluate whether increased blood flow during sitting via low intensity physical activity (fidgetting) prevents the impairment in vascular function and poorer glycemic control associated with prolonged sitting.

Conditions

Obesity; Metabolic Syndrome

Outcome Measures

Primary Outcomes (2)

• glucose tolerance

  glucose area under the curve

  3 hr

• flow mediated dilation

  flow

  every 30 min over 3 hr

Study Arms (2)

Glucose and Fidgetting

EXPERIMENTAL

75 g of glucose will be given at the beginning of the study day (days one with glucose+fidgeting )

Dietary Supplement: Glucose; Behavioral: Fidgetting

Fidgetting

PLACEBO COMPARATOR

Subjects will fidget their legs in an up and down motion for 2.5 min on and then 2.5 min off for the duration of the study.

Behavioral: Fidgetting

Interventions

Glucose DIETARY_SUPPLEMENT

Glucose

Glucose and Fidgetting

Fidgetting BEHAVIORAL

low intensity physical activity (fidgetting)

Also known as: low intensity physical activity

Fidgetting; Glucose and Fidgetting

Eligibility Criteria

• Age: 20 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Obese males and females with metabolic syndrome, aged 20-60 years old.
• According to the NCEP ATP III definition, metabolic syndrome is present if three or more of the following five criteria are met:
• waist circumference over 40 inches (men) or 35 inches (women),
• blood pressure over 130/85 mmHg,
• fasting triglyceride (TG) level over 150 mg/dl,
• fasting high-density lipoprotein (HDL) level less than 40 mg/dl (men) or 50 mg/dl (women)
• fasting blood sugar over 100 mg/dl.

You may not qualify if:

• they smoke
• they have any known cardiovascular, pulmonary or metabolic disease
• have type 2 diabetes
• if good quality Doppler ultrasound image of their arteries cannot be obtained and/or evidence of plaque.

Sponsors & Collaborators

• University of Missouri-Columbia: lead

Study Sites (1)

University of Missouri

Columbia, Missouri, 65211, United States

Location

MeSH Terms

Conditions

Obesity; Metabolic Syndrome

Interventions

Glucose

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Insulin Resistance; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases

Intervention Hierarchy (Ancestors)

Hexoses; Monosaccharides; Sugars; Carbohydrates

Study Officials

• Jill Kanaley, PhD

  University of Missouri-Columbia

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: professor

Model Details: The subject will complete one intervention with consumption of 75 g of glucose with fidgeting and one intervention with no glucose consumption with fidgeting.

Study Record Dates

• First Submitted: January 20, 2018
• First Posted: February 5, 2018
• Study Start: March 20, 2018
• Primary Completion: March 1, 2020
• Study Completion: March 1, 2020
• Last Updated: March 24, 2020

Record last verified: 2020-03

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)